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40
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Text
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Citation List Month
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URL Address
<a href="http://doi.org/10.1097/00002508-200207000-00008" target="_blank" rel="noreferrer">http://doi.org/10.1097/00002508-200207000-00008</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Peripheral blood mononuclear cell beta-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: preliminary report
Publisher
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The Clinical Journal Of Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
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Female; Humans; Male; Adult; Sensitivity and Specificity; Reproducibility of Results; Biomarkers of Pain; Diagnosis; Differential; Leukocytes; Mononuclear/immunology/metabolism; Fatigue Syndrome; beta-Endorphin/blood/immunology/metabolism; Chronic/blood/diagnosis/immunology; Depression/blood/diagnosis; Fibromyalgia/blood/diagnosis/immunology
Creator
An entity primarily responsible for making the resource
Panerai AE; Vecchiet J; Panzeri P; Meroni P; Scarone S; Pizzigallo E; Giamberardino MA; Sacerdote P
Description
An account of the resource
OBJECTIVE: The aim of this study was to examine the possible role of the immune system in the pathophysiology of chronic fatigue syndrome and fibromyalgia syndrome and in the differential diagnosis of depression by investigating changes in peripheral blood mononuclear cell levels of beta-endorphin, an endogenous opioid known to be involved in regulation of the immune system function. DESIGN: Beta-endorphin concentrations were measured by radioimmunoassay in peripheral blood mononuclear cells from healthy controls (n = 8) and patients with chronic fatigue syndrome (n = 17), fibromyalgia syndrome (n = 5), or depression (n = 10). RESULTS: Beta-endorphin concentrations were significantly lower in patients with chronic fatigue syndrome or fibromyalgia syndrome than in normal subjects and depressed patients (p <0.001 and p <0.01, respectively). They were significantly higher in depressed patients than in controls (p <0.01). CONCLUSIONS: Evaluation of peripheral blood mononuclear cell beta-endorphin concentrations could represent a diagnostic tool for chronic fatigue syndrome and fibromyalgia and help with differential diagnosis of these syndromes versus depression. The results obtained are also consistent with the hypothesis that the immune system is activated in both chronic fatigue syndrome and fibromyalgia syndrome.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00002508-200207000-00008" target="_blank" rel="noreferrer">10.1097/00002508-200207000-00008</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adult
Backlog
beta-Endorphin/blood/immunology/metabolism
Biomarkers of Pain
Chronic/blood/diagnosis/immunology
Depression/blood/diagnosis
Diagnosis
Differential
Fatigue Syndrome
Female
Fibromyalgia/blood/diagnosis/immunology
Giamberardino MA
Humans
Journal Article
Leukocytes
Male
Meroni P
Mononuclear/immunology/metabolism
Panerai AE
Panzeri P
Pizzigallo E
Reproducibility of Results
Sacerdote P
Scarone S
Sensitivity and Specificity
The Clinical Journal Of Pain
Vecchiet J
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0196-9781(91)90219-f" target="_blank" rel="noreferrer">http://doi.org/10.1016/0196-9781(91)90219-f</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Age-related changes of beta-endorphin and cholecystokinin in human and rat mononuclear cells
Publisher
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Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
Subject
The topic of the resource
Humans; Male; Adult; Aged; Middle Aged; Animals; Rats; 80 and over; beta-Endorphin/blood; Lymphocyte Activation; Aging/blood/immunology; Cholecystokinin/blood; In Vitro; Interleukin-2/biosynthesis; Leukocytes; Mononuclear/immunology/metabolism
Creator
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Sacerdote P; Breda M; Barcellini W; Meroni PL; Panerai AE
Description
An account of the resource
Beta-endorphin (BE) and cholecystokinin (CCK) were measured in fresh PBMC isolated from human subjects and rats. The BE and CCK PBMC contents increased significantly with age both in human and rat models. Moreover, polyclonal stimulation induced a significant decrease of BE but not CCK contents in mononuclear cells from human aged subjects. The time course of changes in BE and CCK concentrations observed in fresh and cultured cells from subjects of different ages did not directly correlate to the time course of age-associated impairment of lectin-induced lymphocyte proliferative response and interleukin-2 synthesis. In fact, the lymphocyte functional defects were significantly observed only in the 71-99 year age group, whereas the neuropeptide changes were already evident in the 31-50 age group. Since BE has been shown to participate in the modulation of the immune system, the age-related modifications of PBMC BE could play a role in the immunodepression observed during aging.
1991
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0196-9781(91)90219-f" target="_blank" rel="noreferrer">10.1016/0196-9781(91)90219-f</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1991
80 And Over
Adult
Aged
Aging/blood/immunology
Animals
Backlog
Barcellini W
beta-Endorphin/blood
Breda M
Cholecystokinin/blood
Humans
In Vitro
Interleukin-2/biosynthesis
Journal Article
Leukocytes
Lymphocyte Activation
Male
Meroni PL
Middle Aged
Mononuclear/immunology/metabolism
Panerai AE
Peptides
Rats
Sacerdote P