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Text
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URL Address
<a href="http://doi.org/10.1136/jnnp.74.4.495" target="_blank" rel="noreferrer">http://doi.org/10.1136/jnnp.74.4.495</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis
Publisher
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Journal Of Neurology, Neurosurgery, And Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Adult; Middle Aged; Magnetic Resonance Imaging; Phenotype; Biomarkers of Pain; Brain/pathology; Leukocytes; Mononuclear/chemistry; beta-Endorphin/blood/genetics; Multiple Sclerosis/blood/genetics/pathology
Creator
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Gironi M; Furlan R; Rovaris M; Comi G; Filippi M; Panerai AE; Sacerdote P
Description
An account of the resource
The possible link between the opioid peptide beta endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of beta endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest beta endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. Average beta endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that beta endorphin may have a role in the downregulation of the inflammatory process.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/jnnp.74.4.495" target="_blank" rel="noreferrer">10.1136/jnnp.74.4.495</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adult
Backlog
beta-Endorphin/blood/genetics
Biomarkers of Pain
Brain/pathology
Comi G
Female
Filippi M
Furlan R
Gironi M
Humans
Journal Article
Journal Of Neurology, Neurosurgery, And Psychiatry
Leukocytes
Magnetic Resonance Imaging
Male
Middle Aged
Mononuclear/chemistry
Multiple Sclerosis/blood/genetics/pathology
Panerai AE
Phenotype
Rovaris M
Sacerdote P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1046/j.1468-2982.1992.1203155.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1468-2982.1992.1203155.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients
Publisher
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Cephalalgia
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Female; Humans; Male; Adult; Middle Aged; beta-Endorphin/blood; Biomarkers of Pain; Radioimmunoassay; Leukocytes; Headache/blood; Migraine Disorders/blood; Mononuclear/chemistry
Creator
An entity primarily responsible for making the resource
Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G
Description
An account of the resource
Levels of beta-endorphin in peripheral blood mononuclear cells have been studied as a new approach to investigating opioid tone in migraine and tension-type headache. Sixty-one patients with migraine without aura, 39 with migraine with aura and 23 with episodic tension-type headache were compared with 37 healthy controls. Peripheral blood samples were taken from patients not enduring headache attacks and not undergoing prophylactic treatment. A significant reduction in peripheral blood mononuclear cell beta-endorphin concentrations was observed in migraine patients with and without aura, but not in tension-type headache patients. Altered transmitter modulation to peripheral blood mononuclear cells may be the cause of this alteration, which could be part of a more diffuse opioid system derangement in migraine subjects.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1468-2982.1992.1203155.x" target="_blank" rel="noreferrer">10.1046/j.1468-2982.1992.1203155.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
Adult
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Bussone G
Cephalalgia
D'Amico D
Female
Headache/blood
Humans
Journal Article
Leone M
Leukocytes
Male
Middle Aged
Migraine Disorders/blood
Mononuclear/chemistry
Panerai AE
Radioimmunoassay
Sacerdote P