1
40
7
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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URL Address
<a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">http://doi.org/10.1007/978-3-540-33823-9_2</a>
Dublin Core
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Title
A name given to the resource
Opioids
Publisher
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Handbook Of Experimental Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Humans; Analgesics; Animals; Molecular Sequence Data; Chronic disease; Biomarkers of Pain; Drug Tolerance; Receptors; Amino Acid Sequence; Ligands; Opioid/adverse effects/pharmacology/therapeutic use; Opioid/drug effects
Creator
An entity primarily responsible for making the resource
Zollner C; Stein C
Description
An account of the resource
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (mu, delta, kappa) have been identified. Multiple pathways ofopioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca++ channel inhibition) have been described. The differential regulation of effectors, preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">10.1007/978-3-540-33823-9_2</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Amino Acid Sequence
Analgesics
Animals
Backlog
Biomarkers of Pain
Chronic Disease
Drug Tolerance
Handbook Of Experimental Pharmacology
Humans
Journal Article
Ligands
Molecular Sequence Data
Opioid/adverse effects/pharmacology/therapeutic use
Opioid/drug effects
Receptors
Stein C
Zollner C
-
Text
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URL Address
<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">http://doi.org/10.1021/bi0300635</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Human neutrophils as a source of nociceptin: a novel link between pain and inflammation
Publisher
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Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Molecular Sequence Data; Biomarkers of Pain; Receptors; Neutrophils/metabolism; Arthritis/metabolism; Cyclic AMP/metabolism; Inflammation/metabolism; Opioid Peptides/metabolism; Opioid/agonists/genetics/metabolism; Pain/metabolism; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins/metabolism; Synovial Fluid/chemistry/immunology
Creator
An entity primarily responsible for making the resource
Fiset ME; Gilbert C; Poubelle PE; Pouliot M
Description
An account of the resource
Nociceptin is a neuropeptide sharing sequence homology with classical opioid peptides but with a distinct pharmacological profile. Through activation of its receptor, NociR, nociceptin has been linked with several physiological functions in the central nervous system including memory, locomotion, and processing of pain signals. Recently, peripheral blood neutrophils (PMNs) were demonstrated to express a functional NociR, a result suggesting that additional functions of the neuropeptide remain to be elucidated. The present study investigated the possibility that PMNs may be a source of nociceptin and whether the neuropeptide elicits PMN early responses. We observed the presence of nociceptin in the synovial fluids from arthritic patients, an inflammatory milieu typically containing high numbers of PMNs. In addition, freshly isolated PMNs were found to express and secrete nociceptin following degranulation, identifying these inflammatory cells as a novel source of the neuropeptide. Incubation of PMNs with nociceptin elicited a specific pattern of cellular protein phosphorylation on tyrosine residues in a rapid and transient fashion. Moreover, nociceptin prevented intracellular accumulation of cAMP in fMLP-stimulated PMNs, an effect mimicked by the specific NociR synthetic agonist, Ro 64-6198. Taken together, these results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">10.1021/bi0300635</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Arthritis/metabolism
Backlog
Biochemistry
Biomarkers of Pain
Cyclic AMP/metabolism
Fiset ME
Gilbert C
Humans
Inflammation/metabolism
Journal Article
Molecular Sequence Data
Neutrophils/metabolism
Opioid Peptides/metabolism
Opioid/agonists/genetics/metabolism
Pain/metabolism
Phosphorylation
Poubelle PE
Pouliot M
Protein-Tyrosine Kinases/metabolism
Proto-Oncogene Proteins c-hck
Proto-Oncogene Proteins/metabolism
Receptors
Synovial Fluid/chemistry/immunology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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URL Address
<a href="http://doi.org/10.1086/378418" target="_blank" rel="noreferrer">http://doi.org/10.1086/378418</a>
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Title
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Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis
Publisher
An entity responsible for making the resource available
American Journal Of Human Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Female; Humans; Male; Family; Mutation; Animals; Molecular Sequence Data; Non-U.S. Gov't; Research Support; Pedigree; Membrane Proteins/genetics; Base Sequence; Amino Acid Sequence; Amino Acid; DNA Primers; Fibroma/genetics; Genetic Markers; Gingival Hypertrophy/genetics; In Situ Hybridization; Myofibromatosis/genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology; Skin Neoplasms/genetics
Creator
An entity primarily responsible for making the resource
Hanks S; Adams S; Douglas J; Arbour L; Atherton DJ; Balci S; Bode H; Campbell ME; Feingold M; Keser G; Kleijer W; Mancini G; McGrath JA; Muntoni F; Nanda A; Teare MD; Warman M; Pope FM; Superti-Furga A; Futreal PA; Rahman N
Description
An account of the resource
Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are autosomal recessive conditions characterized by multiple subcutaneous skin nodules, gingival hypertrophy, joint contractures, and hyaline deposition. We previously mapped the gene for JHF to chromosome 4q21. We now report the identification of 15 different mutations in the gene encoding capillary morphogenesis protein 2 (CMG2) in 17 families with JHF or ISH. CMG2 is a transmembrane protein that is induced during capillary morphogenesis and that binds laminin and collagen IV via a von Willebrand factor type A (vWA) domain. Of interest, CMG2 also functions as a cellular receptor for anthrax toxin. Preliminary genotype-phenotype analyses suggest that abrogation of binding by the vWA domain results in severe disease typical of ISH, whereas in-frame mutations affecting a novel, highly conserved cytoplasmic domain result in a milder phenotype. These data (1) demonstrate that JHF and ISH are allelic conditions and (2) implicate perturbation of basement-membrane matrix assembly as the cause of the characteristic perivascular hyaline deposition seen in these conditions.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1086/378418" target="_blank" rel="noreferrer">10.1086/378418</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Adams S
American Journal Of Human Genetics
Amino Acid
Amino Acid Sequence
Animals
Arbour L
Atherton DJ
Backlog
Balci S
Base Sequence
Bode H
Campbell ME
DNA Primers
Douglas J
Family
Feingold M
Female
Fibroma/genetics
Futreal PA
Genetic Markers
Gingival Hypertrophy/genetics
Hanks S
Humans
In Situ Hybridization
Journal Article
Keser G
Kleijer W
Male
Mancini G
McGrath JA
Membrane Proteins/genetics
Molecular Sequence Data
Muntoni F
Mutation
Myofibromatosis/genetics
Nanda A
Non-U.S. Gov't
Pedigree
Pope FM
Rahman N
Research Support
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Sequence Homology
Skin Neoplasms/genetics
Superti-Furga A
Teare MD
Warman M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/ana.410340107" target="_blank" rel="noreferrer">http://doi.org/10.1002/ana.410340107</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS): clinical, radiological, pathological, and genetic observations
Publisher
An entity responsible for making the resource available
Annals Of Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
Child; Female; Humans; Male; Molecular Sequence Data; Preschool; infant; Q3 Literature Search; Tomography; X-Ray Computed; Base Sequence; Capillaries/pathology; DNA/analysis; Electron; MELAS Syndrome/genetics/pathology/radiography; Microscopy; Mitochondria/pathology; Muscles/pathology
Creator
An entity primarily responsible for making the resource
Koo B; Becker LE; Chuang S; Merante F; Robinson BH; MacGregor D; Tein I; Ho VB; McGreal DA; Wherrett JR
Description
An account of the resource
We reviewed 10 patients (5 males, 5 females) with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. The age of symptom onset ranged from 3 months to 12 years. All had lactic acidosis, multiple stroke-like events with secondary neurological deficits, radiological changes of progressive brain infarction, and muscle biopsy showing ragged-red fibers. In patients with earlier onset of symptoms (< 2 yr), involvement tended to be more diffuse, with failure to thrive and early onset of delayed development. Patients whose symptoms appeared later tended to have focal neurological deficits with migraine-like headache, and a rate of cognitive regression reflecting the rapidity of disease progression. Radiological changes included multiple areas of infarction with initial predilection for parietal occipital areas, progressing to generalized atrophy. Pathological findings in muscle biopsies included type 1 fiber predominance, ragged-red fibers, increased intermyofibrillar lipid deposition, and abnormal mitochondria. Four patients showed mitochondrial DNA tRNA mutation at position 3,243. No difference was noted in clinical, radiological, or pathological findings in patients with and without this mutation, suggesting that multiple sites of point mutation may give rise to mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes.
1993
Identifier
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<a href="http://doi.org/10.1002/ana.410340107" target="_blank" rel="noreferrer">10.1002/ana.410340107</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
Annals Of Neurology
Backlog
Base Sequence
Becker LE
Capillaries/pathology
Child
Chuang S
DNA/analysis
Electron
Female
Ho VB
Humans
Infant
Journal Article
Koo B
MacGregor D
Male
McGreal DA
MELAS Syndrome/genetics/pathology/radiography
Merante F
Microscopy
Mitochondria/pathology
Molecular Sequence Data
Muscles/pathology
Preschool
Q3 Scoping Review Results
Robinson BH
Tein I
Tomography
Wherrett JR
X-Ray Computed
-
Text
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Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1086/318197" target="_blank" rel="noreferrer">http://doi.org/10.1086/318197</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Genomewide Linkage-Disequilibrium Scan Localizes the Saguenay -Lac-Saint-Jean Cytochrome Oxidase Deficiency to 2p16
Publisher
An entity responsible for making the resource available
American Journal Of Human Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Female; Humans; Male; Mutation; Family Health; Gene Frequency; Molecular Sequence Data; DNA Mutational Analysis; DNA/chemistry/genetics; Pedigree; Chromosomes; Human; Base Sequence; Disease Specific; Chromosome Mapping; Cytochrome-c Oxidase Deficiency; Electron Transport Complex IV/genetics; Genes/genetics; Genome; Haplotypes; Leigh Disease/enzymology/genetics; Linkage Disequilibrium; Microsatellite Repeats; Pair 2/genetics; Polymorphism; Single Nucleotide
Creator
An entity primarily responsible for making the resource
Lee N; Daly MJ; Delmonte T; Lander ES; Xu F; Hudson TJ; Mitchell GA; Morin CC; Robinson BH; Rioux JD
Identifier
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<a href="http://doi.org/10.1086/318197" target="_blank" rel="noreferrer">10.1086/318197</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2001
2001
American Journal Of Human Genetics
Backlog
Base Sequence
Chromosome Mapping
Chromosomes
Cytochrome-c Oxidase Deficiency
Daly MJ
Delmonte T
Disease Specific
DNA Mutational Analysis
DNA/chemistry/genetics
Electron Transport Complex IV/genetics
Family Health
Female
Gene Frequency
Genes/genetics
Genome
Haplotypes
Hudson TJ
Human
Humans
Journal Article
Lander ES
Lee N
Leigh Disease/enzymology/genetics
Linkage Disequilibrium
Male
Microsatellite Repeats
Mitchell GA
Molecular Sequence Data
Morin CC
Mutation
Pair 2/genetics
Pedigree
Polymorphism
Rioux JD
Robinson BH
Single Nucleotide
Xu F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1749-6632.1999.tb08673.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1749-6632.1999.tb08673.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Proopiomelanocortin and the immune-neuroendocrine connection
Publisher
An entity responsible for making the resource available
Annals Of The New York Academy Of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Humans; Animals; Molecular Sequence Data; Biomarkers of Pain; Interleukin-1/physiology; Base Sequence; Immune System/physiology; Neurosecretory Systems/physiology; Neuroimmunomodulation/physiology; Amino Acid Sequence; Biomarkers Reference List; Pro-Opiomelanocortin/genetics/physiology
Creator
An entity primarily responsible for making the resource
Blalock JE
Description
An account of the resource
This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular understanding of neuroimmunomodulation. This, together with the presence of opiate and ACTH receptors on lymphocytes and macrophages, provided the first biochemical circuit for which the same signal molecules and receptors could be used for intrasystem regulation, as well as bidirectional communication between the immune and neuroendocrine systems. Today we have a quite good understanding of the regulation and processing of POMC in immune cells, as well as the interaction of its product peptides with other cytokines. For instance, IL-1 causes POMC production by immune cells, and the POMC product, alpha-MSH, in turn, acts functionally as an IL-1 antagonist. In the past year, the expression of full-length POMC mRNA has been reported and this solved one of the paradoxes with respect to POMC production, processing, and secretion. We provide data on these developments together with quite startling findings on the physiologic function of POMC peptides in the immune system. Among these are the local antinociceptive effects of immune cell-derived beta-endorphin, altered hematopoiesis in opiate receptor-deficient animals, and the diagnosis of ACTH insensitivity by a deficiency of ACTH receptors on lymphocytes.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1749-6632.1999.tb08673.x" target="_blank" rel="noreferrer">10.1111/j.1749-6632.1999.tb08673.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Amino Acid Sequence
Animals
Annals Of The New York Academy Of Sciences
Backlog
Base Sequence
Biomarkers of Pain
Biomarkers Reference List
Blalock JE
Humans
Immune System/physiology
Interleukin-1/physiology
Journal Article
Molecular Sequence Data
Neuroimmunomodulation/physiology
Neurosecretory Systems/physiology
Pro-Opiomelanocortin/genetics/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1210/endo.133.5.8404638" target="_blank" rel="noreferrer">http://doi.org/10.1210/endo.133.5.8404638</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analysis of proopiomelanocortin (POMC) messenger ribonucleic acid and POMC-derived peptides in human peripheral blood mononuclear cells: no evidence for a lymphocyte-derived POMC system
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
Humans; Molecular Sequence Data; Biomarkers of Pain; RNA; Base Sequence; beta-Endorphin/analysis; Biomarkers Reference List; Leukocytes; Lymphocytes/metabolism; Polymerase Chain Reaction; Chromatography; High Pressure Liquid; Pro-Opiomelanocortin/genetics; Mononuclear/metabolism; Blotting; Cathepsin D/metabolism; DNA Probes; Gel; Messenger/blood; Northern; Peptide Fragments/analysis; Peptide Mapping; Southern
Creator
An entity primarily responsible for making the resource
van Woudenberg AD; Metzelaar MJ; van der Kleij AA; de Wied D; Burbach JP; Wiegant VM
Description
An account of the resource
A number of recent studies suggest that cells of the immune system, e.g. peripheral blood mononuclear cells (PBMC), can synthesize and process POMC and secrete POMC-derived peptides, such as ACTH and endorphins, upon immune and hormonal challenges. From this, it has been proposed that POMC-derived peptides originating from lymphoid cells can function as hormones, for instance in a lymphoid-adrenal axis. In view of the important physiological implications of this proposal, the present study was designed to investigate the expression of the POMC gene in human PBMC and the production by these cells of alpha-, beta-, and gamma-endorphins (alpha E, beta E, and gamma E) peptides that are established end products of the posttranslational processing of POMC. PBMC of individual donors were used uncultured (fresh cells) or cultured for 24 and 48 h in the presence and absence of Concanavalin-A (Con-A), bacterial lipopolysaccharide, phytohemagglutinin, or CRH, and vasopressin, conditions that reportedly stimulate POMC activity in those cells, to investigate the presence of POMC transcripts by analysis of total RNA with Northern blotting and the reverse transcriptase polymerase chain reaction (RT-PCR). Large scale preparations containing over 10(9) cells (fresh, cultured with and without Con-A) originating from several donors were examined for the presence of POMC transcripts by analysis of poly(A)+ RNA on Northern blots and for the presence of alpha E, beta E, and gamma E by gel filtration over Sephadex G-75 and reverse phase HPLC, followed by assay of the fractions in four endorphin RIA systems with different specificities. On the Northern blots of total RNA, no POMC transcripts were detectable. In poly(A)+ RNA preparations, no full-length POMC mRNA was found, and it was estimated that the concentration of POMC mRNA, if present, was below approximately 0.005 transcript/cell in Con-A-stimulated cells and still lower in unstimulated cells. In accord with literature data, an 800- to 900-nucleotide POMC transcript was detected in cultured PBMC, and the levels of this transcript were stimulated by Con-A. In all samples analyzed with RT-PCR, a transcript spanning most of exons 2 and 3 was detectable only on Southern blots of the RT-PCR product, but not on agarose gels stained with ethidium bromide. Chromatographic analysis of endorphin immunoreactivities in cell extracts revealed no qualitative differences between the immunoreactive profiles of fresh PBMC or PBMC cultured with or without Con-A.(ABSTRACT TRUNCATED AT 400 WORDS)
1993
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/endo.133.5.8404638" target="_blank" rel="noreferrer">10.1210/endo.133.5.8404638</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
Backlog
Base Sequence
beta-Endorphin/analysis
Biomarkers of Pain
Biomarkers Reference List
Blotting
Burbach JP
Cathepsin D/metabolism
Chromatography
de Wied D
DNA Probes
Endocrinology
Gel
High Pressure Liquid
Humans
Journal Article
Leukocytes
Lymphocytes/metabolism
Messenger/blood
Metzelaar MJ
Molecular Sequence Data
Mononuclear/metabolism
Northern
Peptide Fragments/analysis
Peptide Mapping
Polymerase Chain Reaction
Pro-Opiomelanocortin/genetics
RNA
Southern
van der Kleij AA
van Woudenberg AD
Wiegant VM