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Text
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Citation List Month
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URL Address
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16551896" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16551896</a>
Dublin Core
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Title
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A prospective evaluation of opioid weaning in opioid-dependent pediatric critical care patients
Publisher
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Anesthesia & Analgesia
Date
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2006
Subject
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Child; Female; Humans; Male; Analgesics; Prospective Studies; Double-Blind Method; Preschool; Non-U.S. Gov't; Research Support; PedPal Lit; infant; Comparative Study; Opioid/therapeutic use; Pain/drug therapy/epidemiology; Critical Care/methods/statistics & numerical data; Opioid-Related Disorders/epidemiology; Substance Withdrawal Syndrome/epidemiology
Creator
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Berens RJ; Meyer MT; Mikhailov TA; Colpaert KD; Czarnecki ML; Ghanayem NS; Hoffman GM; Soetenga DJ; Nelson TJ; Weisman SJ
Description
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Critically ill children are treated with opioid medication in an attempt to decrease stress and alleviate pain during prolonged pediatric intensive care. This treatment plan places children at risk for opioid dependency. Once dependent, children need to be weaned or risk development of a withdrawal syndrome on abrupt cessation of medication. We enrolled opioid-dependent children into a prospective, randomized trial of 5- versus 10-day opioid weaning using oral methadone. Children exposed to opioids for an average of 3 wk showed no difference in the number of agitation events requiring opioid rescue (3 consecutive neonatal abstinence scores >8 every 2 h) in either wean group. Most of the events requiring rescue occurred on day 5 and 6 of the wean in both treatment groups. Patients may be able to be weaned successfully in 5 days once converted to oral methadone, with a follow-up period after medication wean to observe for a delayed withdrawal syndrome.
2006
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
Analgesics
Anesthesia & Analgesia
Backlog
Berens RJ
Child
Colpaert KD
Comparative Study
Critical Care/methods/statistics & numerical data
Czarnecki ML
Double-Blind Method
Female
Ghanayem NS
Hoffman GM
Humans
Infant
Journal Article
Male
Meyer MT
Mikhailov TA
Nelson TJ
Non-U.S. Gov't
Opioid-Related Disorders/epidemiology
Opioid/therapeutic use
Pain/drug therapy/epidemiology
PedPal Lit
Preschool
Prospective Studies
Research Support
Soetenga DJ
Substance Withdrawal Syndrome/epidemiology
Weisman SJ