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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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URL Address
<a href="http://doi.org/10.1136/ard.2006.067066" target="_blank" rel="noreferrer">http://doi.org/10.1136/ard.2006.067066</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis
Publisher
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Annals Of The Rheumatic Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
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Female; Humans; Male; Adult; Aged; Middle Aged; 80 and over; Arthritis; Biomarkers of Pain; Opioid; Receptors; Biological Markers/analysis; beta-Endorphin/analysis; Enkephalin; Methionine/analysis; Immunohistochemistry/methods; Arthritis/immunology/metabolism; delta/analysis; Joints/immunology/injuries; Leukocytes/immunology; mu/analysis; Opioid/analysis; Osteoarthritis/immunology/metabolism; Rheumatoid/immunology/metabolism; Synovial Membrane/chemistry/immunology
Creator
An entity primarily responsible for making the resource
Mousa SA; Straub RH; Schafer M; Stein C
Description
An account of the resource
OBJECTIVE: Intra-articularly applied opioid agonists or antagonists modulate pain after knee surgery and in chronic arthritis. Therefore, the expression of beta-endorphin (END), Met-enkephalin (ENK), and mu and delta opioid receptors (ORs) within synovium of patients with joint trauma (JT), osteoarthritis (OA) and rheumatoid arthritis (RA) were examined. METHODS: Synovial samples were subjected to double immunohistochemical analysis of opioid peptides with immune cell markers, and of ORs with the neuronal markers calcitonin gene-related peptide (CGRP) and tyrosine hydroxylase (TH). RESULTS: END and ENK were expressed by macrophage-like (CD68(+)) and fibroblast-like (CD68(-)) cells within synovial lining layers of all disorders. In the sublining layers, END and ENK were mostly expressed by granulocytes in patients with JT, and by macrophages/monocytes, lymphocytes and plasma cells in those with OA and RA. Overall, END- and ENK-immunoreactive (IR) cells were more abundant in patients with RA than in those with OA and JT. ORs were found on nerve fibres and immune cells in all patients. OR-IR nerve fibres were significantly more abundant in patients with RA than in those with OA and JT. muORs and deltaORs were coexpressed with CGRP but not with TH. CONCLUSIONS: Parallel to the severity of inflammation, END and ENK in immune cells and their receptors on sensory nerve terminals are more abundant in patients with RA than in those with JT and OA. These findings are consistent with the notion that, with prolonged and enhanced inflammation, the immune and peripheral nervous systems upregulate sensory nerves expressing ORs and their ligands to counterbalance pain and inflammation.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/ard.2006.067066" target="_blank" rel="noreferrer">10.1136/ard.2006.067066</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
80 And Over
Adult
Aged
Annals Of The Rheumatic Diseases
Arthritis
Arthritis/immunology/metabolism
Backlog
beta-Endorphin/analysis
Biological Markers/analysis
Biomarkers of Pain
delta/analysis
Enkephalin
Female
Humans
Immunohistochemistry/methods
Joints/immunology/injuries
Journal Article
Leukocytes/immunology
Male
Methionine/analysis
Middle Aged
Mousa SA
mu/analysis
Opioid
Opioid/analysis
Osteoarthritis/immunology/metabolism
Receptors
Rheumatoid/immunology/metabolism
Schafer M
Stein C
Straub RH
Synovial Membrane/chemistry/immunology
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
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URL Address
<a href="http://doi.org/10.1016/0003-9969(92)90076-k" target="_blank" rel="noreferrer">http://doi.org/10.1016/0003-9969(92)90076-k</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methionine enkephalin-like, substance P-like, and beta-endorphin-like immunoreactivity in human parotid saliva
Publisher
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Archives Of Oral Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Female; Humans; Male; Adult; Middle Aged; Biomarkers of Pain; beta-Endorphin/analysis; Circadian Rhythm; Enkephalin; Methionine/analysis; Parotid Gland/secretion; Radioimmunoassay; Saliva/chemistry; Salivary Proteins/analysis; Substance P/analysis
Creator
An entity primarily responsible for making the resource
Pikula DL; Harris EF; Desiderio DM; Fridland GH; Lovelace JL
Description
An account of the resource
These three neuropeptides were measured at daily baseline values by radioimmunoassay. Stimulated parotid saliva was collected from 31 subjects using a modified Carlson-Crittenden device affixed over Stenson's duct. Methionine enkephalin-like immunoreactivity ranged from 6.6 to 11.7 fmol/ml, with a mean of 9.3 fmol/ml. Substance P-like immunoreactivity ranged from 6.1 to 12.6 fmol/ml, with a mean of 9.3 fmol/ml. beta-Endorphin-like immunoreactivity ranged from 1.2 to 3.6 fmol/ml, with a mean of 2.6 fmol/ml. This is believed to be the first documentation of methionine enkephalin- and substance P-like activities in human parotid saliva and the first demonstration of beta-endorphin-like activity in any type of human saliva. Substance P-like activity was significantly higher in morning than evening samples; beta-endorphin-like activity also tended to be higher in the morning samples. Substance P and beta-endorphin-like immunoreactivities covaried in a significant positive manner, suggesting either common control mechanisms or similar responses to physiological variables.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0003-9969(92)90076-k" target="_blank" rel="noreferrer">10.1016/0003-9969(92)90076-k</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
Adult
Archives Of Oral Biology
Backlog
beta-Endorphin/analysis
Biomarkers of Pain
Circadian Rhythm
Desiderio DM
Enkephalin
Female
Fridland GH
Harris EF
Humans
Journal Article
Lovelace JL
Male
Methionine/analysis
Middle Aged
Parotid Gland/secretion
Pikula DL
Radioimmunoassay
Saliva/chemistry
Salivary Proteins/analysis
Substance P/analysis
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0021-9673(97)00670-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0021-9673(97)00670-5</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quantitative analysis of methionine enkephalin and beta-endorphin in the pituitary by liquid secondary ion mass spectrometry and tandem mass spectrometry
Publisher
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Journal Of Chromatography.A
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Humans; Animals; Biomarkers of Pain; beta-Endorphin/analysis; Enkephalin; Methionine/analysis; Chromatography; High Pressure Liquid; Mass Spectrometry; Pituitary Gland/chemistry
Creator
An entity primarily responsible for making the resource
Desiderio DM; Zhu X
Description
An account of the resource
This manuscript reviews the use of an off-line combination of liquid chromatography (LC) and mass spectrometry (MS) to quantify endogenous neuropeptides in biological tissues and fluids, and tandem MS (MS/MS) to optimize the molecular specificity of the quantification of native peptides. Reversed-phase high-performance liquid chromatography (RP-HPLC) was used to purify selected endogenous neuropeptides from biological tissues and fluids. Liquid secondary ion MS (LSI-MS), also known as fast atom bombardment (FAB), is used to desorb and to ionize the peptide. The corresponding stable isotope-incorporated synthetic peptide of each peptide is used as the internal standard (I.S.) for quantification. The measurement of methionine enkephalin (ME) and of beta-endorphin1-31 (BE) in the human pituitary is described. This analytical method offers the highest molecular specificity for the measurement of a fully post-translationally modified peptide.
1998
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0021-9673(97)00670-5" target="_blank" rel="noreferrer">10.1016/s0021-9673(97)00670-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Animals
Backlog
beta-Endorphin/analysis
Biomarkers of Pain
Chromatography
Desiderio DM
Enkephalin
High Pressure Liquid
Humans
Journal Article
Journal Of Chromatography.A
Mass Spectrometry
Methionine/analysis
Pituitary Gland/chemistry
Zhu X