Patient-controlled analgesia with intravenous L-methadone in a child with cancer pain refractory to high-dose morphine
Child; Humans; Male; Pain; Analgesics; Analgesia; Treatment Failure; Infusions; Intravenous; Neoplasms/complications; Opioid/administration & dosage/therapeutic use; Patient-Controlled; Morphine/administration & dosage/therapeutic use; Intractable/drug therapy/etiology; Methadone/administration & dosage/therapeutic use
2002
Sabatowski R; Kasper SM; Radbruch L
Journal Of Pain And Symptom Management
2002
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/s0885-3924(01)00389-x" target="_blank" rel="noreferrer">10.1016/s0885-3924(01)00389-x</a>
Opioid switch to oral methadone in cancer pain
Cross-Sectional Studies; Humans; Analgesics; Combined Modality Therapy; Administration; Oral; Pain/drug therapy/etiology; Dose-Response Relationship; Drug; Neoplasms/complications; Receptors; Opioid/administration & dosage/therapeutic use; Morphine/administration & dosage/therapeutic use; Methadone/administration & dosage/therapeutic use; N-Methyl-D-Aspartate/antagonists & inhibitors
The occurrence of undesirable side effects due to opioids (delirium, confusion, myoclonus, nausea, emesis) is one of the major complications in the management of pain, especially in chronic cancer pain states. Methadone, as an alternative to morphine, has been proposed in the control of opioid-induced toxicity. Methadone is a synthetic opioid, with mu and delta receptor activity, associated with the capacity to inhibit N-methyl-D-aspartate receptors. Questions have arisen concerning its equianalgesic ratio since its rediscovery over the past few years and are certainly related to its receptor interactions. Aspects of its pharmacology, indications, and switching modalities are discussed here. Opioid rotation is a new tool in the management of cancer pain, deserving more attention.
2000
Mancini I; Lossignol DA; Body JJ
Current Opinion In Oncology
2000
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1097/00001622-200007000-00006" target="_blank" rel="noreferrer">10.1097/00001622-200007000-00006</a>