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Text
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URL Address
<a href="http://doi.org/10.1136/bmj.283.6284.138-c" target="_blank" rel="noreferrer">http://doi.org/10.1136/bmj.283.6284.138-c</a>
Dublin Core
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Title
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Patient-controlled dose regimen of methadone for chronic cancer pain
Publisher
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British Medical Journal (clinical Research Ed.)
Date
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1981
Subject
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Female; Humans; Male; Adult; Aged; Middle Aged; Drug Administration Schedule; Non-U.S. Gov't; Research Support; Chronic disease; Palliative Care/methods; Neoplasms/therapy; Self Administration; Methadone/administration & dosage/blood
Creator
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Sawe J; Hansen J; Ginman C; Hartvig P; Jakobsson PA; Nilsson MI; Rane A; Anggard E
Description
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Fourteen patients with severe cancer pain participated in a trial of methadone given in a fixed dose (10 mg) but at intervals selected by the patients themselves during the loading phase. The aim was to achieve rapid pain relief while avoiding the risk of toxicity from accumulation of methadone. As expected, the dosage intervals increased gradually over the first few days of treatment, the daily dose decreasing from 30-80 mg on the first day to 10-40 mg at the end of the week. Plasma concentrations of methadone varied sevenfold after four to five days (0.24 to 1.75 mumol/1; 7.4 to 54.2 microgram/100 ml). Eleven patients reported complete or almost complete pain relief and elected to continue with methadone after the study. In no case was treatment withdrawn because of intoxication. From these findings a patient-controlled dosage regimen of oral methadone may be an effective and safe alternative to parenteral narcotic medication, adjusting both for individual variation in pain intensity and for pharmacokinetics.
1981
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/bmj.283.6284.138-c" target="_blank" rel="noreferrer">10.1136/bmj.283.6284.138-c</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1981
Adult
Aged
Anggard E
Backlog
British Medical Journal (clinical Research Ed.)
Chronic Disease
Drug Administration Schedule
Female
Ginman C
Hansen J
Hartvig P
Humans
Jakobsson PA
Journal Article
Male
Methadone/administration & dosage/blood
Middle Aged
Neoplasms/therapy
Nilsson MI
Non-U.S. Gov't
Palliative Care/methods
Rane A
Research Support
Sawe J
Self Administration