1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1097/01.ajp.0000146165.15529.50" target="_blank" rel="noreferrer">http://doi.org/10.1097/01.ajp.0000146165.15529.50</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Oral methadone for chronic noncancer pain: a systematic literature review of reasons for administration, prescription patterns, effectiveness, and side effects Publisher An entity responsible for making the resource available The Clinical Journal Of Pain Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Female; Humans; Male; Pain Measurement; Methadone; Drug Administration Schedule; Non-U.S. Gov't; Research Support; Comparative Study; Chronic disease; Administration; Oral; Dose-Response Relationship; Drug; Methadone/administration & dosage/adverse effects; Narcotics/administration & dosage/adverse effects; Pain/classification/drug therapy; Literature review Creator An entity primarily responsible for making the resource Sandoval JA; Furlan AD; Mailis-Gagnon A Description An account of the resource OBJECTIVE: To assess the indications, prescription patterns, effectiveness, and side effects of oral methadone for the treatment of chronic noncancer pain. METHODS: We conducted searches of several electronic databases, textbooks and reference lists for controlled or uncontrolled studies in humans. Effectiveness was assessed using a dichotomous classification of "meaningful" versus "nonmeaningful" outcomes. RESULTS: Twenty-one papers (1 small randomized trial, 13 case reports, and 7 case series) involving 545 patients with multiple noncancer pain conditions were included. In half of the patients, no specific diagnosis was reported. Methadone was administered primarily when previous opioid treatment was ineffective or produced intolerable side effects. Starting dose ranged from 0.2 to 80 mg/day and maximum dose ranged from 20 to 930 mg/day. Pain outcomes were meaningful in 59% of the patients in the uncontrolled studies. The randomized trial demonstrated a statistically significant improvement in pain for methadone (20 mg/day) compared to placebo. Side effects were considered minor. DISCUSSION: Oral methadone is used for various noncancer pain syndromes, at different settings and with no prescription pattern that could be identifiable. Starting, maintenance, and maximum doses showed great variability. The figure of 59% effectiveness of methadone should be interpreted very cautiously, as it seems overrated due to the poor quality of the uncontrolled studies and their tendency to report positive results. The utilization of oral methadone for noncancer pain is based on primarily uncontrolled literature. Well-designed controlled trials may provide more accurate information on the drug's efficiency in pain syndromes and in particular neuropathic pain. 2005 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1097/01.ajp.0000146165.15529.50" target="_blank" rel="noreferrer">10.1097/01.ajp.0000146165.15529.50</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2005 Administration Backlog Chronic Disease Comparative Study Dose-Response Relationship Drug Drug Administration Schedule Female Furlan AD Humans Journal Article Literature review Mailis-Gagnon A Male Methadone Methadone/administration & dosage/adverse effects Narcotics/administration & dosage/adverse effects Non-U.S. Gov't Oral Pain Measurement Pain/classification/drug therapy Research Support Sandoval JA The Clinical Journal Of Pain