1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1097/00003246-199307000-00012" target="_blank" rel="noreferrer">http://doi.org/10.1097/00003246-199307000-00012</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pharmacokinetics of continuous infusions of fentanyl in critically ill children
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
adolescent; Child; Humans; infant; Male; Critical Illness; Prospective Studies; Fentanyl; Half-Life; Preschool; Newborn; Infusions; Intravenous; Metabolic Clearance Rate
Creator
An entity primarily responsible for making the resource
Katz R; Kelly HW
Description
An account of the resource
OBJECTIVE: To determine the pharmacokinetics of fentanyl when used as a long-term continuous infusion for sedation/analgesia in mechanically ventilated critically ill infants and children. DESIGN: Prospective, case series. SETTING: A university hospital pediatric intensive care unit (ICU). PATIENTS: Nineteen mechanically ventilated infants and children (0.05 to 14 yrs of age) who received continuous infusions of fentanyl for > 24 hrs. INTERVENTIONS: None. MEASUREMENTS: Plasma concentrations of fentanyl were measured 1 hr after a loading dose and at various intervals during and after the infusions were discontinued. Noncompartmental pharmacokinetic variables, total body clearance, volume of distribution at steady state, and terminal elimination half-life were calculated. Clinical sedation scores, ventilatory settings, pupillary size and reactivity, and patient demographics were recorded. RESULTS: After the use of fentanyl by long-term infusion, the volume of distribution at steady state was increased 15.2 L/kg (range 5.1 to 30.5) and the terminal elimination half-life was prolonged 21.1 hrs (range 11.2 to 36.0) compared with previous studies. Clearance was rapid and consistent with other studies. There was a large interpatient variability in clearance that was age dependent. Clearance did not appear to increase over time. CONCLUSIONS: Total body clearance of fentanyl is highly variable and it should be dosed to effect. Patients seen in a pediatric ICU may require a ten-fold variability in fentanyl infusion rates to achieve similar levels of sedation.
1993-07
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199307000-00012" target="_blank" rel="noreferrer">10.1097/00003246-199307000-00012</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
Adolescent
Backlog
Child
Critical Care Medicine
Critical Illness
Fentanyl
Half-Life
Humans
Infant
Infusions
Intravenous
Journal Article
Katz R
Kelly HW
Male
Metabolic Clearance Rate
Newborn
Preschool
Prospective Studies
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1080/j354v16n04_02" target="_blank" rel="noreferrer">http://doi.org/10.1080/j354v16n04_02</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Clinical pharmacokinetics of morphine
Publisher
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Journal of Pain and Palliative Care Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Humans; infant; Adult; Aged; Drug Interactions; Biotransformation; Half-Life; Tissue Distribution; infant; Administration; Newborn; Oral; Injections; Intravenous; Delayed-Action Preparations; Aging/metabolism; Metabolic Clearance Rate; Dosage Forms; Intestinal Absorption; Morphine/administration & dosage/metabolism/pharmacokinetics; Neoplasms/metabolism
Creator
An entity primarily responsible for making the resource
Lugo RA; Kern SE
Description
An account of the resource
Morphine, the most widely used mu-opioid analgesic for acute and chronic pain, is the standard against which new analgesics are measured. A thorough understanding of the pharmacokinetics of morphine is required in order to safely and effectively use this analgesic in a wide variety of patients with different levels of organ function. A MEDLINE search was conducted to identify literature published between 1966 and January 2002 relevant to the pharmacokinetics of morphine. These publications were reviewed and the literature summarized regarding unique and clinically important elements of morphine disposition relative to its parenteral administration (including intravenous, intramuscular, subcutaneous, epidural and intrathecal administration), absorption profile (immediate release, controlled release, and sublingual/buccal, and rectal administration), distribution, and its metabolism/excretion. Special populations, including infants, elderly, and those with renal/liver failure, have a unique morphine pharmacokinetic profile that must be taken into account in order to maximize analgesic efficacy and reduce the risk of adverse events.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/j354v16n04_02" target="_blank" rel="noreferrer">10.1080/j354v16n04_02</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Administration
Adult
Aged
Aging/metabolism
Backlog
Biotransformation
Child
Delayed-Action Preparations
Dosage Forms
Drug Interactions
Half-Life
Humans
Infant
Injections
Intestinal Absorption
Intravenous
Journal Article
Journal of Pain and Palliative Care Pharmacotherapy
Kern SE
Lugo RA
Metabolic Clearance Rate
Morphine/administration & dosage/metabolism/pharmacokinetics
Neoplasms/metabolism
Newborn
Oral
Tissue Distribution
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0889-8588(02)00017-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0889-8588(02)00017-5</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The use of methadone for cancer pain
Publisher
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Hematology/oncology Clinics Of North America
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Humans; Analgesics; Attitude of Health Personnel; Treatment Outcome; Information Dissemination; Patient Selection; Drug Interactions; Clinical Protocols; Drug Administration Schedule; Practice; Attitudes; Health Knowledge; Palliative Care/methods; Dose-Response Relationship; Drug; Neoplasms/complications; Pain/diagnosis/drug therapy/etiology; Biological Availability; Drug Costs; Drug Industry/economics; Drug Information Services; Metabolic Clearance Rate; Methadone/chemistry/economics/pharmacology/therapeutic use; Morphine/pharmacology/therapeutic use; Opioid/chemistry/economics/pharmacology/therapeutic use
Creator
An entity primarily responsible for making the resource
Ripamonti C; Bianchi M
Description
An account of the resource
Methadone is not a new analgesic drug [69]. Several studies have demonstrated that methadone is a valid alternative to morphine, hydromorphone, and fentanyl for the treatment of cancer-related pain, and extensive reviews on the subject have been published in recent years [10,23,25,64,70,71]. Most people involved in pain therapy, however, are not well informed about the properties of methadone. The authors believe that the low cost of methadone paradoxically contributes to the limited knowledge of its characteristics and to the restricted therapeutic use of this drug. The low cost of methadone means there is little financial incentive for pharmaceutical companies to invest in research or to disseminate scientific information. Unfortunately, the lack of scientific information from pharmaceutical companies frequently results in a lack of knowledge on the part of physicians. Unless the existing approach changes, both culturally and politically, ignorance about methadone will persist among medical experts. The low cost of methadone, rather than being an advantage, will result in the limited exploitation of an effective drug.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0889-8588(02)00017-5" target="_blank" rel="noreferrer">10.1016/s0889-8588(02)00017-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Analgesics
Attitude Of Health Personnel
Attitudes
Backlog
Bianchi M
Biological Availability
Child
Clinical Protocols
Dose-Response Relationship
Drug
Drug Administration Schedule
Drug Costs
Drug Industry/economics
Drug Information Services
Drug Interactions
Health Knowledge
Hematology/oncology Clinics Of North America
Humans
Information Dissemination
Journal Article
Metabolic Clearance Rate
Methadone/chemistry/economics/pharmacology/therapeutic use
Morphine/pharmacology/therapeutic use
Neoplasms/complications
Opioid/chemistry/economics/pharmacology/therapeutic use
Pain/diagnosis/drug therapy/etiology
Palliative Care/methods
Patient Selection
Practice
Ripamonti C
Treatment Outcome