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Text
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URL Address
<a href="http://doi.org/10.1016/0304-3959(94)90084-1" target="_blank" rel="noreferrer">http://doi.org/10.1016/0304-3959(94)90084-1</a>
Dublin Core
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Title
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Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists
Publisher
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Pain
Date
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1994
Subject
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Child; Female; Humans; Male; Adult; Analgesics; Aged; Middle Aged; Pain/complications/drug therapy; Neoplasms/complications; Delayed-Action Preparations; Methadone/therapeutic use; Narcotics/therapeutic use; Hyperalgesia/chemically induced/psychology; Meperidine/analogs & derivatives/therapeutic use; Morphine/administration & dosage/adverse effects/therapeutic use; Myoclonus/chemically induced; Opioid/therapeutic use; Sufentanil/therapeutic use
Creator
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Sjogren P; Jensen NH; Jensen TS
Description
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Hyperalgesia and allodynia in 4 cancer patients treated with morphine disappeared after discontinuing or substituting morphine with other opioid agonists. The first case describes a young female who developed hyperalgesia and myoclonus during intravenous morphine infusion. The hyperalgesia and myoclonus disappeared when the morphine administration was discontinued and she felt comfortable on small and sporadic oral doses of methadone. The second case describes hyperalgesia occurring after a small dose of sustained-release morphine which disappeared after alternative use of oral ketobemidone. The third case describes hyperalgesia following high doses of intramuscular morphine which disappeared after alternative use of continuous subcutaneous infusion of sufentanil. The fourth case describes a boy developing hyperalgesia after high doses of oral and intramuscular morphine. The hyperalgesia disappeared after discontinuing morphine administration but withdrawal symptoms developed due to too small doses of methadone. Possible mechanisms of morphine-induced hyperalgesia are discussed.
1994
Identifier
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<a href="http://doi.org/10.1016/0304-3959(94)90084-1" target="_blank" rel="noreferrer">10.1016/0304-3959(94)90084-1</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1994
Adult
Aged
Analgesics
Backlog
Child
Delayed-Action Preparations
Female
Humans
Hyperalgesia/chemically induced/psychology
Jensen NH
Jensen TS
Journal Article
Male
Meperidine/analogs & derivatives/therapeutic use
Methadone/therapeutic use
Middle Aged
Morphine/administration & dosage/adverse effects/therapeutic use
Myoclonus/chemically induced
Narcotics/therapeutic use
Neoplasms/complications
Opioid/therapeutic use
Pain
Pain/complications/drug therapy
Sjogren P
Sufentanil/therapeutic use