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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
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<a href="http://doi.org/10.1016/j.nmd.2004.09.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nmd.2004.09.004</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Sleep disordered breathing in spinal muscular atrophy
Publisher
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Neuromuscular Disorders
Date
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2004
Subject
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Child; Cyclic AMP; Response Element-Binding Protein; Disease Progression; Female; Humans; Male; Muscle; Skeletal/pa [Pathology] Muscle; breathing difficulties; SMA1; physical intervention; non-invasive positive pressure ventilation; disordered breathing
Creator
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Mellies U; Dohna-Schwake C; Stehling F V T
Description
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Sleep disordered breathing is a common but under-diagnosed complication causing sleep disturbance and daytime symptoms in children with spinal muscular atrophy. Non-invasive (positive pressure) ventilation is an established treatment of respiratory failure; its role in treatment of sleep disordered breathing though remains controversial. Aim of this study was to verify the hypothesis that nocturnal non-invasive ventilation has beneficial impact on breathing during sleep, sleep quality and daytime complaints in children with spinal muscular atrophy. Twelve children with spinal muscular atrophy type I or II (7.8+/-1.9 years) underwent polysomnography and were asked to fill out a symptom questionnaire. Seven patients (six with spinal muscular atrophy I and one with spinal muscular atrophy II) had sleep disordered breathing and received non-invasive ventilation during sleep. Five less severely affected patients (one with spinal muscular atrophy I and four with spinal muscular atrophy II) had no sleep disordered breathing and served as reference group. Patients were restudied after 6-12 months. In patients with sleep disordered breathing both sleep architecture and disease related symptoms were significantly worse than in the reference-group. Non-invasive ventilation during sleep completely eliminated disordered breathing, normalized sleep architecture and improved symptoms (P<0.05 for all). In children with spinal muscular atrophy sleep disordered breathing may cause relevant impairment of sleep and well-being. Both can be highly improved by nocturnal non-invasive ventilation.
Identifier
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<a href="http://doi.org/10.1016/j.nmd.2004.09.004" target="_blank" rel="noreferrer noopener">10.1016/j.nmd.2004.09.004</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
breathing difficulties
Child
Cyclic AMP
Disease Progression
disordered breathing
Dohna-Schwake C
Female
Humans
Male
Mellies U
Muscle
Neuromuscular Disorders
non-invasive positive pressure ventilation
physical intervention
Response Element-Binding Protein
Skeletal/pa [Pathology] Muscle
SMA1
Stehling F V T