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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/NEJMoa013171" target="_blank" rel="noreferrer">http://doi.org/10.1056/NEJMoa013171</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Risperidone in children with autism and serious behavioral problems
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Treatment Outcome; Double-Blind Method; adolescent; Preschool; Non-U.S. Gov't; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Antipsychotic Agents/administration & dosage/adverse effects/therapeutic use; Autistic Disorder/drug therapy/psychology; Child Behavior/drug effects; Risperidone/administration & dosage/adverse effects/therapeutic use
Creator
An entity primarily responsible for making the resource
McCracken JT; McGough J; Shah B; Cronin P; Hong D; Aman MG; Arnold LE; Lindsay R; Nash P; Hollway J; McDougle CJ; Posey D; Swiezy N; Kohn A; Scahill L; Martin A; Koenig K; Volkmar F; Carroll D; Lancor A; Tierney E; Ghuman J; Gonzalez NM; Grados M; Vitiello B; Ritz L; Davies M; Robinson J; McMahon D; Research Units on Pediatric Psychopharmacology (RUPP) Autism Network
Description
An account of the resource
BACKGROUND: Atypical antipsychotic agents, which block postsynaptic dopamine and serotonin receptors, have advantages over traditional antipsychotic medications in the treatment of adults with schizophrenia and may be beneficial in children with autistic disorder who have serious behavioral disturbances. However, data on the safety and efficacy of atypical antipsychotic agents in children are limited. METHODS: We conducted a multisite, randomized, double-blind trial of risperidone as compared with placebo for the treatment of autistic disorder accompanied by severe tantrums, aggression, or self-injurious behavior in children 5 to 17 years old. The primary outcome measures were the score on the Irritability subscale of the Aberrant Behavior Checklist and the rating on the Clinical Global Impressions - Improvement (CGI-I) scale at eight weeks. RESULTS: A total of 101 children (82 boys and 19 girls; mean [+/-SD] age, 8.8+/-2.7 years) were randomly assigned to receive risperidone (49 children) or placebo (52). Treatment with risperidone for eight weeks (dose range, 0.5 to 3.5 mg per day) resulted in a 56.9 percent reduction in the Irritability score, as compared with a 14.1 percent decrease in the placebo group (P<0.001). The rate of a positive response, defined as at least a 25 percent decrease in the Irritability score and a rating of much improved or very much improved on the CGI-I scale, was 69 percent in the risperidone group (34 of 49 children had a positive response) and 12 percent in the placebo group (6 of 52, P<0.001). Risperidone therapy was associated with an average weight gain of 2.7+/-2.9 kg, as compared with 0.8+/-2.2 kg with placebo (P<0.001). Increased appetite, fatigue, drowsiness, dizziness, and drooling were more common in the risperidone group than in the placebo group (P<0.05 for each comparison). In two thirds of the children with a positive response to risperidone at eight weeks (23 of 34), the benefit was maintained at six months. CONCLUSIONS: Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder. The short period of this trial limits inferences about adverse effects such as tardive dyskinesia.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/NEJMoa013171" target="_blank" rel="noreferrer">10.1056/NEJMoa013171</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Adolescent
Aman MG
Antipsychotic Agents/administration & dosage/adverse effects/therapeutic use
Arnold LE
Autistic Disorder/drug therapy/psychology
Backlog
Carroll D
Child
Child Behavior/drug effects
Comparative Study
Cronin P
Davies M
Double-Blind Method
Female
Ghuman J
Gonzalez NM
Grados M
Hollway J
Hong D
Humans
Journal Article
Koenig K
Kohn A
Lancor A
Lindsay R
Male
Martin A
McCracken JT
McDougle CJ
McGough J
McMahon D
Nash P
Non-U.S. Gov't
P.H.S.
Posey D
Preschool
Research Support
Research Units on Pediatric Psychopharmacology (RUPP) Autism Network
Risperidone/administration & dosage/adverse effects/therapeutic use
Ritz L
Robinson J
Scahill L
Shah B
Swiezy N
The New England Journal Of Medicine
Tierney E
Treatment Outcome
U.S. Gov't
Vitiello B
Volkmar F
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/j.rasd.2011.06.015" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.rasd.2011.06.015</a>
<a href="http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000297826400048" target="_blank" rel="noreferrer">http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000297826400048</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Depression and anxiety symptoms in children and adolescents with autism spectrum disorders without intellectual disability
Publisher
An entity responsible for making the resource available
Research In Autism Spectrum Disorders
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
Subject
The topic of the resource
Prevalence; Comorbidity; Depression; Anxiety; Children; Adolescents; Autism; DEVELOPMENTAL; PSYCHIATRY; Psychology; ASPERGER-SYNDROME; At Risk Persons; Depression/psychology; DIAGNOSTIC INTERVIEW; Education; FRIENDSHIP; Intelligence Quotient; parent; People; PERVASIVE DEVELOPMENTAL DISORDERS; PSYCHIATRIC-DISORDERS; Rehabilitation; Special; Symptoms (Individual Disorders); VERSION
Creator
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Strang JF; Kenworthy L; Daniolos P; Case L; Wills MC; Martin A; Wallace GL
Description
An account of the resource
Recent studies have shown that rates of depression and anxiety symptoms are elevated among individuals with autism spectrum disorders (ASDs) of various ages and IQs and that depression/anxiety symptoms are associated with higher IQ and fewer ASD symptoms. In this study which examined correlates of depression and anxiety symptoms in the full school-age range of children and adolescents (age 6-18) with ASDs and IQs greater than or equal to 70 (n = 95), we also observed elevated rates of depression/anxiety symptoms, but we did not find higher IQ or fewer ASD symptoms among individuals with ASDs and depression or anxiety symptoms. These findings indicate an increased risk for depression/anxiety symptoms in children and adolescents with ASDs without intellectual disability, regardless of age, IQ, or ASD symptoms. (Contains 2 tables and 1 figure.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.rasd.2011.06.015" target="_blank" rel="noreferrer">10.1016/j.rasd.2011.06.015</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2012
Adolescents
anxiety
ASPERGER-SYNDROME
At Risk Persons
Autism
Backlog
Case L
Children
Comorbidity
Daniolos P
Depression
Depression/psychology
DEVELOPMENTAL
DIAGNOSTIC INTERVIEW
Education
FRIENDSHIP
Intelligence Quotient
Journal Article
Kenworthy L
Martin A
Parent
People
PERVASIVE DEVELOPMENTAL DISORDERS
Prevalence
PSYCHIATRIC-DISORDERS
Psychiatry
Psychology
Rehabilitation
Research In Autism Spectrum Disorders
Special
Strang JF
Symptoms (Individual Disorders)
VERSION
Wallace GL
Wills MC