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              <text>&lt;a href="http://doi.org/10.1097/00005176-200204000-00011" target="_blank" rel="noreferrer"&gt;http://doi.org/10.1097/00005176-200204000-00011&lt;/a&gt;</text>
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                <text>Polyethylene glycol without electrolytes for children with constipation and encopresis</text>
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            <name>Publisher</name>
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                <text>Journal Of Pediatric Gastroenterology And Nutrition</text>
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                <text>2002</text>
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                <text>Child; Female; Humans; Male; Follow-Up Studies; Prospective Studies; Time Factors; adolescent; Preschool; Non-U.S. Gov't; Research Support; Polyethylene Glycols/therapeutic use; Constipation/therapy; Encopresis/therapy; Iowa</text>
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                <text>Loening-Baucke V</text>
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                <text>BACKGROUND: Children with functional constipation and encopresis benefit from behavior modification and from long-term laxative medication. Polyethylene glycol without electrolytes has become the first option for many pediatric gastroenterologists. METHODS: Twenty-eight children treated with polyethylene glycol without electrolytes were compared with 21 children treated with milk of magnesia to evaluate the efficiency, acceptability, side effects, and treatment dosage of polyethylene glycol in long-term treatment of functional constipation and encopresis. Children were rated as "doing well," "improved," or "not doing well," depending on resolution of constipation and encopresis. RESULTS: At the 1-, 3-, 6-, and 12-month follow-ups, bowel movement frequency increased and soiling frequency decreased significantly in both groups. At the 1-month follow-up, children on polyethylene glycol were soiling more frequently (P &lt; 0.01) and fewer were improved (P &lt; 0.01). At the 3- and 6-month follow-ups, both groups had similarly improved. At the 12-month visit, 61% of children on polyethylene glycol and 67% of children on milk of magnesia were doing well. Children on polyethylene glycol soiled more frequently (P &lt; 0.01). None refused polyethylene glycol, but 33% refused to take milk of magnesia. The mean initial treatment dosage of polyethylene glycol was 0.6 +/- 0.2 g/kg daily. Polyethylene glycol had no taste, and no loss of efficacy occurred. Polyethylene glycol did not cause clinically significant side effects. CONCLUSIONS: Polyethylene glycol without electrolytes is an alternative for long-term management of children with constipation and encopresis.</text>
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                <text>2002</text>
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                <text>Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).</text>
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        <name>Loening-Baucke V</name>
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                <text>Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children</text>
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                <text>Archives Of Pediatrics &amp; Adolescent Medicine</text>
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                <text>2003</text>
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                <text>Child; Female; Humans; Male; Questionnaires; Prospective Studies; Patient Compliance; adolescent; Preschool; Non-U.S. Gov't; Research Support; Chronic disease; Alanine Transaminase/blood; Cathartics/therapeutic use; Constipation/drug therapy; Encopresis/drug therapy; Polyethylene Glycols/therapeutic use</text>
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                <text>OBJECTIVES: To assess the clinical and biochemical safety profile of long-term polyethylene glycol 3350 (PEG) therapy in children with chronic constipation and to assess pediatric patient acceptance of PEG therapy. DESIGN: Prospective observational study. SETTING: Pediatric clinics at a referral center.Patients Eighty-three children (44 with chronic constipation, 39 with constipation and encopresis) receiving PEG therapy for more than 3 months. MAIN OUTCOME MEASURES: Clinical adverse effects related to PEG therapy and acceptance and compliance with PEG therapy. Serum electrolyte levels, osmolality, albumin levels, and liver and renal function test results were measured. RESULTS: At the time of evaluation, the mean duration of PEG therapy was 8.7 months, and the mean PEG dose was 0.75 g/kg daily. There were no major clinical adverse effects. All blood test results were normal, except for transient minimal alanine aminotransferase elevation unrelated to therapy in 9 patients. All children preferred PEG to previously used laxatives, and daily compliance was measured as good in 90% of children. CONCLUSIONS: Long-term PEG therapy is safe and is well accepted by children with chronic constipation with and without encopresis.</text>
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                <text>2003</text>
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            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="84887">
                <text>Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).</text>
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