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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
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<a href="http://doi.org/10.1016/j.ejpn.2015.09.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejpn.2015.09.007</a>
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Gabapentin can significantly improve dystonia severity and quality of life in children
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European Journal of Paediatric Neurology
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2016
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tone and motor problems; IND; pharmacologic intervention; gabapentin; involuntary muscle contractions
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Liow N Y; Gimeno H; Lumsden D E; Marianczak J; Kaminska M; Tomlin S; Lin J S
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INTRODUCTION: Gabapentin has been used in the management of neuropathic pain, epilepsy and occasionally movement disorders. METHODS: A four-year retrospective, observational study analysed the use of gabapentin for severe dystonia in children at the Evelina London Children's Hospital. Motor severity was classified according to the Gross Motor Function Classification System (GMFCS), Dystonia Severity Assessment Plan (DSAP) and levels of impairment in activities of daily living were graded according to the WHO International Classification of Functioning, Disability and Health, Children & Youth version (ICF-CY) before and after gabapentin. RESULTS: The majority of the 69 children reported were level 5 GMFCS (non-ambulant). The DSAP grade fell significantly from grade 3 before to grade 1 after gabapentin. Significant improvements in median ICF-CY grades were seen following gabapentin in sleep quality, sleep amount, mood & agreeableness, pain, general muscle tone, involuntary muscle contractions and seating tolerance (p < 0.01 in all areas). A significantly higher mean dose of 18.1 mg/kg/dose (SD: 13.3) for dystonia, compared to 7.61 mg/kg/dose (SD: 4.14) for pain relief without dystonia (z = -2.54, p = 0.011) was noted. DISCUSSION & CONCLUSION: Gabapentin may significantly ameliorate dystonia severity and improve activities of daily living and quality of life in children with severe dystonia.
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<a href="http://doi.org/10.1016/j.ejpn.2015.09.007" target="_blank" rel="noreferrer noopener">10.1016/j.ejpn.2015.09.007</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
European Journal of Paediatric Neurology
Gabapentin
Gimeno H
IND
involuntary muscle contractions
Kaminska M
Lin J S
Liow N Y
Lumsden D E
Marianczak J
pharmacologic intervention
Tomlin S
tone and motor problems