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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">http://doi.org/10.1007/978-3-540-33823-9_2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Opioids
Publisher
An entity responsible for making the resource available
Handbook Of Experimental Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Humans; Analgesics; Animals; Molecular Sequence Data; Chronic disease; Biomarkers of Pain; Drug Tolerance; Receptors; Amino Acid Sequence; Ligands; Opioid/adverse effects/pharmacology/therapeutic use; Opioid/drug effects
Creator
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Zollner C; Stein C
Description
An account of the resource
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (mu, delta, kappa) have been identified. Multiple pathways ofopioid receptor signaling (e.g., G(i/o) coupling, cAMP inhibition, Ca++ channel inhibition) have been described. The differential regulation of effectors, preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
2007
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/978-3-540-33823-9_2" target="_blank" rel="noreferrer">10.1007/978-3-540-33823-9_2</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2007
Amino Acid Sequence
Analgesics
Animals
Backlog
Biomarkers of Pain
Chronic Disease
Drug Tolerance
Handbook Of Experimental Pharmacology
Humans
Journal Article
Ligands
Molecular Sequence Data
Opioid/adverse effects/pharmacology/therapeutic use
Opioid/drug effects
Receptors
Stein C
Zollner C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1038/nm908" target="_blank" rel="noreferrer">http://doi.org/10.1038/nm908</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Attacking pain at its source: new perspectives on opioids
Publisher
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Nature Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Analgesics; Animals; Non-U.S. Gov't; Research Support; Drug Tolerance; Receptors; Ligands; Afferent/metabolism; Cell Movement; Neurons; Opioid Peptides/metabolism/therapeutic use; Opioid/genetics/metabolism; Opioid/metabolism/therapeutic use; Pain/drug therapy/metabolism/therapy; Signal Transduction/physiology
Creator
An entity primarily responsible for making the resource
Stein C; Schafer M; Machelska H
Description
An account of the resource
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide-containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/nm908" target="_blank" rel="noreferrer">10.1038/nm908</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Afferent/metabolism
Analgesics
Animals
Backlog
Cell Movement
Drug Tolerance
Humans
Journal Article
Ligands
Machelska H
Nature Medicine
Neurons
Non-U.S. Gov't
Opioid Peptides/metabolism/therapeutic use
Opioid/genetics/metabolism
Opioid/metabolism/therapeutic use
Pain/drug therapy/metabolism/therapy
Receptors
Research Support
Schafer M
Signal Transduction/physiology
Stein C