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40
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Text
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Citation List Month
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URL Address
<a href="http://doi.org/10.1016/j.pain.2004.06.020" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.pain.2004.06.020</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Potential links between leukocytes and antinociception
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
Subject
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Humans; Animals; Leukocytes/physiology; Neuroimmunomodulation/physiology; Nociceptors/physiology
Creator
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Brack A; Stein C
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pain.2004.06.020" target="_blank" rel="noreferrer">10.1016/j.pain.2004.06.020</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2004
2004
Animals
Backlog
Brack A
Humans
Journal Article
Leukocytes/physiology
Neuroimmunomodulation/physiology
Nociceptors/physiology
Pain
Stein C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/jlb.58.2.137" target="_blank" rel="noreferrer">http://doi.org/10.1002/jlb.58.2.137</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Associations between the neuroendocrine and immune systems
Publisher
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Journal Of Leukocyte Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
Subject
The topic of the resource
Humans; Animals; Biomarkers of Pain; Cell Communication; Cytokines/physiology; Hormones/physiology; Hypothalamo-Hypophyseal System/physiology; Immune System/physiology; Interleukins/physiology; Leukocytes/physiology; Neurosecretory Systems/physiology; Signal Transduction
Creator
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Weigent DA; Blalock JE
Description
An account of the resource
Organisms respond to infection with complex adaptations involving bidirectional communication between the immune and neuroendocrine systems. The idea of intercellular communication between the neuroendocrine and immune systems via common signal molecules has provided a conceptual framework for such crosstalk. The studies to date show that cells of the immune system contain receptors for neuroendocrine hormones and can also be considered a source of pituitary and hypothalamic peptides. The structure and pattern of synthesis of these peptides by leukocytes appear similar to neuroendocrine hormones, although some differences exist. Once secreted, these peptide hormones may function as endogenous regulators of the immune system as well as conveyors of information from the immune to the neuroendocrine system. The plasma hormone concentrations contributed by lymphocytes usually do not reach the levels required when the pituitary gland is the source, but because immune cells are mobile, they have the potential to locally deposit the hormone at the target site. Likewise, other studies show that cells of the neuroendocrine system contain receptors for cytokines and can also be considered a source of cytokines, particularly interleukin-1 (IL-1) and IL-6. In the pituitary IL-1 beta coexists with thyroid stimulating hormone in a subpopulation of thyrotropes, suggesting it may have a role as a pituitary paracrine factor. The cytokines, including IL-1, IL-2, IL-6, interferon-gamma, and tumor necrosis factor, exert profound effects on hypothalamic pituitary axes. It is our hypothesis that the relay of information to the neuroendocrine system represents a sensory function for the immune system wherein leukocytes recognize stimuli that are not recognizable by the central and peripheral nervous systems (i.e., bacteria, tumors, viruses, and antigens). The recognition of such noncognitive stimuli by immunocytes is then converted into information and a physiological change occurs. Future studies into the physiological role that cytokines and neuroendocrine hormones have in these systems will be of considerable interest for both immunologists and endocrinologists.
1995
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jlb.58.2.137" target="_blank" rel="noreferrer">10.1002/jlb.58.2.137</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1995
Animals
Backlog
Biomarkers of Pain
Blalock JE
Cell Communication
Cytokines/physiology
Hormones/physiology
Humans
Hypothalamo-Hypophyseal System/physiology
Immune System/physiology
Interleukins/physiology
Journal Article
Journal Of Leukocyte Biology
Leukocytes/physiology
Neurosecretory Systems/physiology
Signal Transduction
Weigent DA