Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study
Male; Nervous System Diseases; Medical Records; Nervous System Diseases/complications; Sex Factors; Dose-Response Relationship Drug; Child; Humans; Adolescent; Female; Child Preschool; Infant; Developmental Disabilities; Epilepsy/complications; Epilepsy; Outpatients; Vision Disorders/complications; Developmental Disabilities/complications; Melatonin/therapeutic use; Sleep Disorders/complications/drug therapy; Q3 Literature Search; Melatonin; Sleep Wake Disorders; child; female; male; Vision Disorders; sleep disturbance/disorders; Lennox-Gastaut syndrome; leukodystrophy; MPSII; MPSIII; pharmacologic intervention; melatonin
The study aim was to quantify melatonin-associated improvement in sleep by means of a parent-completed sleep diary during routine outpatient activity. An investigation into sleep disturbance was made at neurology outpatient appointments. Those parents who identified a problem were asked to complete a sleep diary, after which treatment was initiated. The first week of the diary was completed before treatment, the second when established on the maximum dose of melatonin required. Forty-nine patients (26 males, 23 females) aged from one to 13 years, were treated between 1997 and 1998: 28 of these returned interpretable diaries. In a further 18 patients, an assessment could be made of the usefulness of the treatment. Patients were fairly typical of those attending a tertiary centre, the most common primary diagnosis being epilepsy (n=26). Only seven patients were visually impaired. Of the 46 patients who were assessed, 34 showed an improvement. No adverse effects were attributed to the treatment.
Ross C; Davies P; Whitehouse W
Developmental Medicine and Child Neurology
2002
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1017/s0012162201002171" target="_blank" rel="noreferrer noopener">10.1017/s0012162201002171</a>
Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders
sleep disturbance/disorders; congenital hydrocephalus; Lennox-Gastaut syndrome; West syndrome; trajectory; characteristics; LGS
The daily rhythms of melatonin, cortisol and body temperature were studied in 16 institutionalized subjects with the Lennox-Gastaut syndrome. The results of 9 subjects with normal daily rhythms of sleep and wakefulness (group 1) were compared with those of 7 subjects with disordered sleep (group 2). Salivary samples were collected and axillary temperature was measured every 2 h during two or three separate 26-h periods. The hormones were measured by radioimmunoassays. The rhythms were characterized with single cosinor analysis. Two subjects in group 1 and six subjects in group 2 had abnormalities in their rhythms of temperature, cortisol or melatonin. All three rhythms were disrupted in two subjects of group 2. These two subjects were the only ones with disrupted cortisol rhythm. The diversity of rhythm pathologies suggested partly separate regulatory mechanisms for each rhythm. The co-occurrence of circadian rhythm sleep disorders with the deteriorated melatonin rhythm raised the question as to whether the sleep disorders of these subjects, like those of subjects with healthy brains, could be relieved by the induction of normal melatonin rhythm.
Laakso M L; Leinonen L; Hätönen T; Alila A; Heiskala H
Journal of Neurology
1993
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1007/bf00867353" target="_blank" rel="noreferrer noopener">10.1007/bf00867353</a>