1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0140-6736(93)91471-w" target="_blank" rel="noreferrer">http://doi.org/10.1016/0140-6736(93)91471-w</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Local analgesic effect of endogenous opioid peptides
Publisher
An entity responsible for making the resource available
Lancet
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
Humans; Pain; Adult; Aged; Middle Aged; Double-Blind Method; Biomarkers of Pain; Injections; Intravenous; Receptors; Opioid/drug effects; Immunohistochemistry; Enkephalin; Arthroscopy; beta-Endorphin/analysis/physiology; Dynorphins/analysis/physiology; Endorphins/analysis/physiology; Intra-Articular; Knee Joint/surgery; Methionine/analysis/physiology; Naloxone/administration & dosage/pharmacology; Postoperative/etiology; Synovial Membrane/chemistry; Synovitis/metabolism
Creator
An entity primarily responsible for making the resource
Stein C; Hassan AH; Lehrberger K; Giefing J; Yassouridis A
Description
An account of the resource
Opioids produce analgesia by interacting with local opioid receptors in peripheral inflamed tissue. This study investigated whether endogenous ligands of these receptors are present in synovia and whether such opioid peptides can inhibit pain by activation of intra-articular opioid receptors. Samples of synovium from 8 patients undergoing arthroscopic knee surgery were examined by immunohistochemistry for the presence of beta-endorphin, met-enkephalin, and dynorphin. All tissue samples showed synovitis. Inflammatory cells stained strongly for beta-endorphin and met-enkephalin but not for dynorphin. To find out whether blockade of intra-articular opioid receptors affected pain, we randomly assigned 22 patients undergoing arthroscopic knee surgery to receive naloxone (0.04 mg) intra-articularly (n = 10) or intravenously (n = 12); each patient received a placebo injection into the other site. Postoperative pain was assessed by visual analogue scale, a numerical rating scale, the McGill pain questionnaire, and supplementary analgesic consumption during the next 24 h. All pain scores were higher in the intra-articular naloxone group than in the intravenous naloxone group. The differences were significant (p < 0.05) during the first 4 h. Supplementary analgesic consumption was significantly higher in the intra-articular group (52.5 [14.0] vs 15.6 [8.0] mg diclofenac, p < 0.05). Opioid peptides are present in inflamed synovial tissue and can inhibit pain after knee surgery through an action specific to intra-articular opioid receptors. These findings expand the gate control theory of pain and suggest new approaches such as the development of peripherally acting opioid analgesics without central side-effects.
1993
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0140-6736(93)91471-w" target="_blank" rel="noreferrer">10.1016/0140-6736(93)91471-w</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
Adult
Aged
Arthroscopy
Backlog
beta-Endorphin/analysis/physiology
Biomarkers of Pain
Double-Blind Method
Dynorphins/analysis/physiology
Endorphins/analysis/physiology
Enkephalin
Giefing J
Hassan AH
Humans
Immunohistochemistry
Injections
Intra-Articular
Intravenous
Journal Article
Knee Joint/surgery
Lancet
Lehrberger K
Methionine/analysis/physiology
Middle Aged
Naloxone/administration & dosage/pharmacology
Opioid/drug effects
Pain
Postoperative/etiology
Receptors
Stein C
Synovial Membrane/chemistry
Synovitis/metabolism
Yassouridis A