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Text
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<a href="http://doi.org/10.1016/0306-4522(92)90509-z" target="_blank" rel="noreferrer">http://doi.org/10.1016/0306-4522(92)90509-z</a>
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Title
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Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception
Publisher
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Neuroscience
Date
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1992
Subject
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Male; Pain Measurement; Analysis of Variance; Animals; Nucleic Acid Hybridization; Rats; Non-U.S. Gov't; Research Support; Biomarkers of Pain; RNA; Biomarkers Reference List; Inbred Strains; beta-Endorphin/genetics/metabolism; Calcitonin Gene-Related Peptide/analysis/metabolism; Endorphins/analysis/genetics/metabolism; Freund's Adjuvant; Gene Expression/radiation effects; Hindlimb; Inflammation/immunology/physiopathology; Messenger/genetics/metabolism; Nerve Fibers/physiology/ultrastructure; Oligonucleotide Probes; Pain/immunology/physiopathology; T-Lymphocytes/immunology/pathology; Whole-Body Irradiation
Creator
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Przewlocki R; Hassan AH; Lason W; Epplen C; Herz A; Stein C
Description
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Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tissue, identify opioid containing cells and demonstrate their functional significance in the inhibition of nociception. In rats with Freund's adjuvant-induced unilateral hindpaw inflammation we show that: (i) pro-opiomelanocortin and proenkephalin-mRNAs (but not prodynorphin mRNA) are abundant in cells of inflamed, but absent in non-inflamed tissue; (ii) numerous cells infiltrating the inflamed subcutaneous tissue are stained intensely with beta-endorphin and [Met]enkephalin (but only few scattered cells with dynorphin) antibodies; (iii) beta-endorphin is present in T- and B-lymphocytes, monocytes and macrophages; and (iv) whole-body irradiation suppresses stress-induced antinociception in the inflamed paw. Taken together, these data suggest that endogenous opioid peptides are synthesized and processed within various types of immune cells at the site of inflammation. Immunosuppression abolishes the intrinsic antinociception in inflammatory tissue confirming the functional significance of these cells.
1992
Identifier
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<a href="http://doi.org/10.1016/0306-4522(92)90509-z" target="_blank" rel="noreferrer">10.1016/0306-4522(92)90509-z</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1992
Analysis of Variance
Animals
Backlog
beta-Endorphin/genetics/metabolism
Biomarkers of Pain
Biomarkers Reference List
Calcitonin Gene-Related Peptide/analysis/metabolism
Endorphins/analysis/genetics/metabolism
Epplen C
Freund's Adjuvant
Gene Expression/radiation effects
Hassan AH
Herz A
Hindlimb
Inbred Strains
Inflammation/immunology/physiopathology
Journal Article
Lason W
Male
Messenger/genetics/metabolism
Nerve Fibers/physiology/ultrastructure
Neuroscience
Non-U.S. Gov't
Nucleic Acid Hybridization
Oligonucleotide Probes
Pain Measurement
Pain/immunology/physiopathology
Przewlocki R
Rats
Research Support
RNA
Stein C
T-Lymphocytes/immunology/pathology
Whole-Body Irradiation