1
40
2
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1741-4520.2012.00356.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1741-4520.2012.00356.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-dependent change in behavioral feature in Rubinstein-Taybi syndrome
Publisher
An entity responsible for making the resource available
Congenital Anomalies
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
Subject
The topic of the resource
Adolescent; Adult; Age; Factors; Behavior; Child; Preschool; Female; Humans; Infant; Male; Rubinstein-Taybi Syndrome/di [Diagnosis]; Surveys and Questionnaires; Young Adult; behavioral problems; Rubinstein-Taybi Syndrome; trajectory; characteristics; anxiety; depression; aggression; aggressive behavior
Creator
An entity primarily responsible for making the resource
Yagihashi T; Kosaki K; Okamoto N; Mizuno S; Kurosawa K; Takahashi T; Sato Y; Kosaki R
Description
An account of the resource
Rubinstein-Taybi syndrome (RTS) is characterized by developmental delay, postnatal growth retardation, typical facial appearance, and broad thumbs and big toes. The behavioral phenotype of children with RTS has been described as friendly and having good social contacts; however, a short attention span and hyperactivity are sometimes present. Little attention has been paid to the behavioral aspects of adults with RTS. We conducted an observational study focusing on behavioral problems in adolescents and adults with RTS compared with children with RTS. A total of 63 patients with RTS and their caretakers answered self-administered questionnaires regarding behavioral features including the Child Behavior Checklist (CBCL). High total CBCL scores were observed, and the mean score was beyond the clinical cut-off point. After stratification into two groups according to age, the older group (>14 years) displayed statistically significant higher scores for Anxious/Depression (P = 0.002) and Aggressive Behavior (P = 0.036) than the younger group (<13 years). In analyses of single items, statistically significant differences between the younger group and the older group were found for 'Nervous, high-strung, or tense' (31.3% vs 67.7%, P = 0.004) and 'Too fearful or anxious' (37.5% vs 64.5%, P = 0.032). Here, we showed that the specific behavioral phenotypes of RTS change during adolescence, with anxiety, mood instability, and aggressive behavior emerging as patients age. A clear need exists to follow-up patients with RTS to catch the eventual emergence of psychiatric problems with age. If necessary, pharmacological treatment should be considered.Copyright © 2012 The Authors. Congenital Anomalies © 2012 Japanese Teratology Society.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1741-4520.2012.00356.x" target="_blank" rel="noreferrer noopener">10.1111/j.1741-4520.2012.00356.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Adolescent
Adult
Age
Aggression
aggressive behavior
anxiety
Behavior
behavioral problems
characteristics
Child
Congenital Anomalies
Depression
Factors
Female
Humans
Infant
Kosaki K
Kosaki R
Kurosawa K
Male
Mizuno S
Okamoto N
Preschool
Rubinstein-Taybi Syndrome
Rubinstein-Taybi Syndrome/di [Diagnosis]
Sato Y
Surveys And Questionnaires
Takahashi T
Trajectory
Yagihashi T
Young Adult
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajmg.a.10236" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajmg.a.10236</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Further delineation of the behavioral and neurologic features in Costello syndrome
Publisher
An entity responsible for making the resource available
American Journal of Medical Genetics Part A
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Male; Child; Humans; Adolescent; Female; Child Preschool; Infant; Abnormalities Multiple/physiopathology/psychology; Intellectual Disability/physiopathology/psychology; behavioral problems; feeding difficulties; Costello syndrome; trajectory; characteristics; irritability; sleep disturbance
Creator
An entity primarily responsible for making the resource
Kawame H; Matsui M; Kurosawa K; Matsuo M; Masuno M; Ohashi H; Fueki N; Aoyama K; Miyatsuka Y; Suzuki K; Akatsuka A; Ochiai Y; Fukushima Y
Description
An account of the resource
To describe clinical and neurodevelopmental phenotypes of Costello syndrome, we performed a retrospective review of the clinical records and findings in 10 children with Costello syndrome. All patients showed significant postnatal growth retardation and severe feeding difficulties leading to failure to thrive from early infancy. All required tube feeding and some needed high-calorie formulas for variable periods. Developmental quotients/IQs in seven children were 50 or less, and three were in the mildly retarded range. Five had seizures. Remarkable manifestations not previously reported were the characteristic behavior in infancy. Although happy and sociable personality was always emphasized in the genetic literature, all children showed significant irritability, including hypersensitivity to sound and tactile stimuli, sleep disturbance, and excess shyness with strangers in infancy. Those symptoms usually disappeared around age 2-4 years. Other clinical signs included cardiac abnormalities (8), musculoskeletal abnormalities (10), ophthalmological manifestations (5), increased urinary vanillymandelic acid (VMA) and homovanillic acid (HVA) (3), rhabdomyosarcoma (1), laryngomalacia (1), and cryptorchidism (1). Only three girls had papillomata. Family histories were negative for Costello syndrome. In conclusion, we confirm the wide spectrum of mental function in patients with Costello syndrome, which ranges from severe to mild. During infancy Costello syndrome showed remarkable irritability with severe feeding problems, which attributes significant difficulties to the parents of affected children.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/ajmg.a.10236" target="_blank" rel="noreferrer noopener">10.1002/ajmg.a.10236</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Abnormalities Multiple/physiopathology/psychology
Adolescent
Akatsuka A
American Journal of Medical Genetics Part A
Aoyama K
behavioral problems
characteristics
Child
Child Preschool
costello syndrome
feeding difficulties
Female
Fueki N
Fukushima Y
Humans
Infant
Intellectual Disability/physiopathology/psychology
Irritability
Kawame H
Kurosawa K
Male
Masuno M
Matsui M
Matsuo M
Miyatsuka Y
Ochiai Y
Ohashi H
sleep disturbance
Suzuki K
Trajectory