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Dublin Core
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
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<a href="http://doi.org/10.1007/s00381-017-3361-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00381-017-3361-x</a>
Dublin Core
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Title
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Considerations in deep brain stimulation (DBS) for pediatric secondary dystonia
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Childs Nervous System
Date
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2017
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Pediatrics; Surgery; Neurosciences & Neurology; cerebral-palsy; Deep brain stimulation; globus-pallidus internus; hemidystonia; Secondary dystonia; Pediatric neurosurgery; surgical-treatment; tone and motor problems; IND; surgical intervention; deep brain stimulation; dystonia
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Tsering D; Tochen L; Lavenstein B; Reddy S K; Granader Y; Keating R F; Oluigbo C O
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Purpose There is a paucity of effective long-term medication treatment for secondary dystonias. In situations where significantly impairing secondary dystonias fail to respond to typical enteral medications and intrathecal (or even intraventricular) baclofen, consideration should be given to the use of deep brain stimulation (DBS). While Level I evidence and long-term follow-up clearly demonstrate the efficacy of DBS for primary dystonia, the evidence for secondary dystonia remains mixed and unclear. In this study, we report our experience with pediatric subjects who have undergone DBS for secondary dystonia. Methods We discuss the indications and outcomes of DBS procedures completed at our center. We also present a detailed discussion of the considerations in the management of these patients as well as a literature review. Results Of the four cases retrospectively examined here, all subjects experienced reductions in the severity of their dystonia (ranging from 0 to 100% on both the Barry-Albright Dystonia (BAD) and Burke-Fahn-Marsden Dystonia Rating Scale-Motor (BFMDRS-M) scales). Conclusions Pallidal DBS should be considered among children with functionally debilitating, medication-resistant secondary dystonia. Patients without fixed skeletal deformities who have experienced a short duration of symptoms are most likely to benefit from this intervention.
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<a href="http://doi.org/10.1007/s00381-017-3361-x" target="_blank" rel="noreferrer noopener">10.1007/s00381-017-3361-x</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
cerebral-palsy
Childs Nervous System
deep brain stimulation
Dystonia
globus-pallidus internus
Granader Y
hemidystonia
IND
Keating R F
Lavenstein B
Neurosciences & Neurology
Oluigbo C O
Pediatric neurosurgery
Pediatrics
Reddy S K
secondary dystonia
Surgery
surgical intervention
surgical-treatment
Tochen L
tone and motor problems
Tsering D