1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1371/journal.pone.0047569" target="_blank" rel="noreferrer">http://doi.org/10.1371/journal.pone.0047569</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endogenous opioids in wound-site neutrophils of sternotomy patients
Publisher
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Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
Subject
The topic of the resource
Female; Humans; Male; Aged; Middle Aged; beta-Endorphin/blood; Biomarkers of Pain; Enkephalin; Biomarkers Reference List; Postoperative Period; Pain Management; Neutrophils/metabolism; Inflammation/metabolism; Flow Cytometry; Gene Expression Regulation; Dynorphins/blood; Interleukin-10/metabolism; Interleukin-4/metabolism; Methionine/blood; Sternotomy/methods; Wound Healing
Creator
An entity primarily responsible for making the resource
Awad H; Abas M; Elgharably H; Tripathi R; Theofilos T; Bhandary S; Sai-Sudhakar C; Sen CK; Roy S
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0047569" target="_blank" rel="noreferrer">10.1371/journal.pone.0047569</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2012
Abas M
Aged
Awad H
Backlog
beta-Endorphin/blood
Bhandary S
Biomarkers of Pain
Biomarkers Reference List
Dynorphins/blood
Elgharably H
Enkephalin
Female
Flow Cytometry
Gene Expression Regulation
Humans
Inflammation/metabolism
Interleukin-10/metabolism
Interleukin-4/metabolism
Journal Article
Male
Methionine/blood
Middle Aged
Neutrophils/metabolism
Pain Management
PLoS One
Postoperative Period
Roy S
Sai-Sudhakar C
Sen CK
Sternotomy/methods
Theofilos T
Tripathi R
Wound Healing
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">http://doi.org/10.1021/bi0300635</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Human neutrophils as a source of nociceptin: a novel link between pain and inflammation
Publisher
An entity responsible for making the resource available
Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Molecular Sequence Data; Biomarkers of Pain; Receptors; Neutrophils/metabolism; Arthritis/metabolism; Cyclic AMP/metabolism; Inflammation/metabolism; Opioid Peptides/metabolism; Opioid/agonists/genetics/metabolism; Pain/metabolism; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins/metabolism; Synovial Fluid/chemistry/immunology
Creator
An entity primarily responsible for making the resource
Fiset ME; Gilbert C; Poubelle PE; Pouliot M
Description
An account of the resource
Nociceptin is a neuropeptide sharing sequence homology with classical opioid peptides but with a distinct pharmacological profile. Through activation of its receptor, NociR, nociceptin has been linked with several physiological functions in the central nervous system including memory, locomotion, and processing of pain signals. Recently, peripheral blood neutrophils (PMNs) were demonstrated to express a functional NociR, a result suggesting that additional functions of the neuropeptide remain to be elucidated. The present study investigated the possibility that PMNs may be a source of nociceptin and whether the neuropeptide elicits PMN early responses. We observed the presence of nociceptin in the synovial fluids from arthritic patients, an inflammatory milieu typically containing high numbers of PMNs. In addition, freshly isolated PMNs were found to express and secrete nociceptin following degranulation, identifying these inflammatory cells as a novel source of the neuropeptide. Incubation of PMNs with nociceptin elicited a specific pattern of cellular protein phosphorylation on tyrosine residues in a rapid and transient fashion. Moreover, nociceptin prevented intracellular accumulation of cAMP in fMLP-stimulated PMNs, an effect mimicked by the specific NociR synthetic agonist, Ro 64-6198. Taken together, these results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/bi0300635" target="_blank" rel="noreferrer">10.1021/bi0300635</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Arthritis/metabolism
Backlog
Biochemistry
Biomarkers of Pain
Cyclic AMP/metabolism
Fiset ME
Gilbert C
Humans
Inflammation/metabolism
Journal Article
Molecular Sequence Data
Neutrophils/metabolism
Opioid Peptides/metabolism
Opioid/agonists/genetics/metabolism
Pain/metabolism
Phosphorylation
Poubelle PE
Pouliot M
Protein-Tyrosine Kinases/metabolism
Proto-Oncogene Proteins c-hck
Proto-Oncogene Proteins/metabolism
Receptors
Synovial Fluid/chemistry/immunology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1042/bse0390105" target="_blank" rel="noreferrer">http://doi.org/10.1042/bse0390105</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The final step in programmed cell death: phagocytes carry apoptotic cells to the grave.
Publisher
An entity responsible for making the resource available
Essays In Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Animals; Models; Receptors; Signal Transduction; Molecular; Inflammation/metabolism; Apoptosis; Phagocytosis; Biological; Caenorhabditis elegans/genetics; Cell Surface/me [Metabolism]; Drosophila melanogaster/genetics; Evolution; Mice/genetics; Phagocytes/physiology
Creator
An entity primarily responsible for making the resource
deCathelineau AM; Henson PM
Description
An account of the resource
As cells undergo apoptosis, they are recognized and removed from the body by phagocytes. This oft-overlooked yet critical final step in the cell-death programme protects tissues from exposure to the toxic contents of dying cells and also serves to prevent further tissue damage by stimulating production of anti-inflammatory cytokines and chemokines. The clearance of apoptotic-cell corpses occurs throughout the lifespan of multicellular organisms and is important for normal development during embryogenesis, the maintenance of normal tissue integrity and function, and the resolution of inflammation. Many of the signal-transduction molecules implicated in the phagocytosis of apoptotic cells appear to have a high degree of evolutionary conservation, and therefore the engulfment of apoptotic cells is likely to represent one of the most primitive forms of phagocytosis. With the realization that the signals that govern apoptotic-cell removal also serve to attenuate inflammation and the immune response, as well as initiate signals for tissue repair and remodelling in response to cell death, the study of apoptotic cell clearance is a field experiencing a dynamic increase in interest and momentum.
2003
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1042/bse0390105" target="_blank" rel="noreferrer">10.1042/bse0390105</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2003
Animals
Apoptosis
Backlog
Biological
Caenorhabditis elegans/genetics
Cell Surface/me [Metabolism]
deCathelineau AM
Drosophila melanogaster/genetics
Essays In Biochemistry
Evolution
Henson PM
Inflammation/metabolism
Journal Article
Mice/genetics
Models
Molecular
Phagocytes/physiology
Phagocytosis
Receptors
Signal Transduction