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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
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URL Address
<a href="http://doi.org/10.1016/0304-3959(90)91112-v" target="_blank" rel="noreferrer">http://doi.org/10.1016/0304-3959(90)91112-v</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
Subject
The topic of the resource
Male; Analysis of Variance; Animals; Rats; Biomarkers of Pain; Dose-Response Relationship; Drug; Receptors; Naloxone/pharmacology; Foot; Biomarkers Reference List; Adrenalectomy; Cold; Endorphins/physiology; Hypophysectomy; Inbred Strains; Inflammation/physiopathology; Naltrexone/pharmacology; Nociceptors/physiopathology; Opioid/physiology; Pituitary-Adrenal System/physiology; Stress/physiopathology; Swimming
Creator
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Parsons CG; Czlonkowski A; Stein C; Herz A
Description
An account of the resource
This study investigated the involvement of endogenous opioid peptides in mediating cold water swim (CWS) stress-induced antinociception (SIA) in rats with unilateral hind paw inflammation induced by Freund's complete adjuvant (FCA). Following 0.5, 1 and 2 min of CWS, there was a duration-dependent elevation of paw pressure threshold (PPT) in both inflamed and non-inflamed paws which was maximal immediately after CWS and returned to control values within 15 min. The antinociception elicited in the inflamed paw was significantly greater than that elicited in the non-inflamed paw. The antinociception induced by a 1 min CWS was dose dependently antagonized by tertiary naloxone (0.125-1 mg/kg s.c.) and completely reversed by tertiary naltrexone (0.5 mg/kg). Quaternary naltrexone (5-40 mg/kg s.c.) was similarly effective in reversing the elevation of inflamed PPT induced by a 1 min CWS stress. In contrast, similar doses of quaternary naltrexone had no effect against centrally mediated morphine antinociception in non-inoculated rats. Adrenalectomy was without effect on the pattern of SIA seen in FCA-treated rats. Surgical hypophysectomy completely abolished the differential antinociception induced by 0.5 and 1 min durations of CWS but had little effect on that following 2 min of CWS stress. Inhibition of hypophysial corticotrophic cell secretion with dexamethasone (300 micrograms/kg) injected s.c. 120 min prior to CWS completely abolished the differential SIA at all durations of CWS tested. beta-Endorphin 12.5 micrograms/kg administered i.v. in non-stressed rats also caused a greater elevation of PPT in inflamed than in non-inflamed paws. This effect was not reversed by concomitant i.v. administration of (-) tertiary naloxone 5 mg/kg or quaternary naltrexone 20 mg/kg.
1990
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3959(90)91112-v" target="_blank" rel="noreferrer">10.1016/0304-3959(90)91112-v</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1990
Adrenalectomy
Analysis of Variance
Animals
Backlog
Biomarkers of Pain
Biomarkers Reference List
Cold
Czlonkowski A
Dose-Response Relationship
Drug
Endorphins/physiology
Foot
Herz A
Hypophysectomy
Inbred Strains
Inflammation/physiopathology
Journal Article
Male
Naloxone/pharmacology
Naltrexone/pharmacology
Nociceptors/physiopathology
Opioid/physiology
Pain
Parsons CG
Pituitary-Adrenal System/physiology
Rats
Receptors
Stein C
Stress/physiopathology
Swimming
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0306-4522(92)90509-z" target="_blank" rel="noreferrer">http://doi.org/10.1016/0306-4522(92)90509-z</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception
Publisher
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Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Male; Pain Measurement; Analysis of Variance; Animals; Nucleic Acid Hybridization; Rats; Non-U.S. Gov't; Research Support; Biomarkers of Pain; RNA; Biomarkers Reference List; Inbred Strains; beta-Endorphin/genetics/metabolism; Calcitonin Gene-Related Peptide/analysis/metabolism; Endorphins/analysis/genetics/metabolism; Freund's Adjuvant; Gene Expression/radiation effects; Hindlimb; Inflammation/immunology/physiopathology; Messenger/genetics/metabolism; Nerve Fibers/physiology/ultrastructure; Oligonucleotide Probes; Pain/immunology/physiopathology; T-Lymphocytes/immunology/pathology; Whole-Body Irradiation
Creator
An entity primarily responsible for making the resource
Przewlocki R; Hassan AH; Lason W; Epplen C; Herz A; Stein C
Description
An account of the resource
Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tissue, identify opioid containing cells and demonstrate their functional significance in the inhibition of nociception. In rats with Freund's adjuvant-induced unilateral hindpaw inflammation we show that: (i) pro-opiomelanocortin and proenkephalin-mRNAs (but not prodynorphin mRNA) are abundant in cells of inflamed, but absent in non-inflamed tissue; (ii) numerous cells infiltrating the inflamed subcutaneous tissue are stained intensely with beta-endorphin and [Met]enkephalin (but only few scattered cells with dynorphin) antibodies; (iii) beta-endorphin is present in T- and B-lymphocytes, monocytes and macrophages; and (iv) whole-body irradiation suppresses stress-induced antinociception in the inflamed paw. Taken together, these data suggest that endogenous opioid peptides are synthesized and processed within various types of immune cells at the site of inflammation. Immunosuppression abolishes the intrinsic antinociception in inflammatory tissue confirming the functional significance of these cells.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-4522(92)90509-z" target="_blank" rel="noreferrer">10.1016/0306-4522(92)90509-z</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
Analysis of Variance
Animals
Backlog
beta-Endorphin/genetics/metabolism
Biomarkers of Pain
Biomarkers Reference List
Calcitonin Gene-Related Peptide/analysis/metabolism
Endorphins/analysis/genetics/metabolism
Epplen C
Freund's Adjuvant
Gene Expression/radiation effects
Hassan AH
Herz A
Hindlimb
Inbred Strains
Inflammation/immunology/physiopathology
Journal Article
Lason W
Male
Messenger/genetics/metabolism
Nerve Fibers/physiology/ultrastructure
Neuroscience
Non-U.S. Gov't
Nucleic Acid Hybridization
Oligonucleotide Probes
Pain Measurement
Pain/immunology/physiopathology
Przewlocki R
Rats
Research Support
RNA
Stein C
T-Lymphocytes/immunology/pathology
Whole-Body Irradiation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1152/ajplung.1992.263.1.l88" target="_blank" rel="noreferrer">http://doi.org/10.1152/ajplung.1992.263.1.l88</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chronic hypoxia selectively augments rat pulmonary artery Ca2+ and K+ channel-mediated relaxation.
Publisher
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The American Journal Of Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
The topic of the resource
Male; Animals; Rats; Chronic disease; Inbred Strains; Anoxia/me [Metabolism]; Calcium Channels/ph [Physiology]; Potassium Channels/ph [Physiology]; Pulmonary Artery/me [Metabolism]; Vasoconstriction; Anoxia/pp [Physiopathology]; Calcium/me [Metabolism]; Cyclic AMP/ph [Physiology]; Cyclic GMP/ph [Physiology]; Endothelium; Extracellular Space/me [Metabolism]; Pulmonary Artery/de [Drug Effects]; Pulmonary Artery/pp [Physiopathology]; Vascular/ph [Physiology]; Vasodilator Agents/pd [Pharmacology]
Creator
An entity primarily responsible for making the resource
Rodman DM
Description
An account of the resource
The initiating event in hypoxic pulmonary hypertension is felt to be sustained hypoxic vasoconstriction, ultimately leading to vascular remodeling and fixed pulmonary hypertension. During the initial vasospastic phase endogenous vasodilatory pathways may serve to ameliorate the development of pulmonary hypertension. However, various studies in the systemic and pulmonary circulations have shown that chronic hemodynamic stress alters both endothelial and smooth muscle cell function. The effect of chronic hypoxia in rats was therefore tested on three major vasodilatory pathways: 1) endothelium-dependent relaxation (using endothelium-derived relaxing factor agonists and antagonists); 2) smooth muscle cell cyclic nucleotide-mediated relaxation [using guanosine and adenosine 3',5'-cyclic monophosphate (cGMP and cAMP) agonists]; and 3) ion channel-dependent relaxation (using K+ channel agonists and Ca2+ channel antagonists). It was found that short-term exposure (72 h) to hypoxia caused augmentation of K+ and Ca2+ channel-dependent relaxation with no effect on endothelium-dependent or cyclic nucleotide-mediated relaxation. More prolonged exposure (4-5 wk) was additionally associated with inhibition of endothelium-dependent relaxation and smooth muscle cell cGMP-mediated relaxation. There was no effect on either basal modulation of tone by the endothelium, cAMP-mediated relaxation, or systemic vessel relaxation. It is concluded that an early response to hemodynamic stress in the pulmonary circulation is alteration in smooth muscle cell ion channel function and/or Ca2+ homeostasis.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.1992.263.1.l88" target="_blank" rel="noreferrer">10.1152/ajplung.1992.263.1.l88</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
Animals
Anoxia/me [Metabolism]
Anoxia/pp [Physiopathology]
Backlog
Calcium Channels/ph [Physiology]
Calcium/me [Metabolism]
Chronic Disease
Cyclic AMP/ph [Physiology]
Cyclic GMP/ph [Physiology]
Endothelium
Extracellular Space/me [Metabolism]
Inbred Strains
Journal Article
Male
Potassium Channels/ph [Physiology]
Pulmonary Artery/de [Drug Effects]
Pulmonary Artery/me [Metabolism]
Pulmonary Artery/pp [Physiopathology]
Rats
Rodman DM
The American Journal Of Physiology
Vascular/ph [Physiology]
Vasoconstriction
Vasodilator Agents/pd [Pharmacology]