1
40
6
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Text
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URL Address
<a href="http://doi.org/10.1016/s0074-7742(02)52006-7" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0074-7742(02)52006-7</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neuropeptides: modulators of immune responses in health and disease
Publisher
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International Review Of Neurobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Animals; Non-U.S. Gov't; Research Support; Immune System/physiology; Neurotransmitter Agents/physiology; Autoimmune Diseases/immunology; Neuropeptides/physiology; Stress/immunology
Creator
An entity primarily responsible for making the resource
Jessop DS
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0074-7742(02)52006-7" target="_blank" rel="noreferrer">10.1016/s0074-7742(02)52006-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Animals
Autoimmune Diseases/immunology
Backlog
Humans
Immune System/physiology
International Review Of Neurobiology
Jessop DS
Journal Article
Neuropeptides/physiology
Neurotransmitter Agents/physiology
Non-U.S. Gov't
Research Support
Stress/immunology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1213/00000539-200210000-00039" target="_blank" rel="noreferrer">http://doi.org/10.1213/00000539-200210000-00039</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Immune mechanisms in pain control
Publisher
An entity responsible for making the resource available
Anesthesia & Analgesia
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Analgesics; Animals; Non-U.S. Gov't; Research Support; Receptors; Immune System/physiology; Opioid/physiology; Opioid/pharmacology; Immunity; Endorphins/metabolism; Cellular/physiology; Pain/drug therapy/immunology/pathology
Creator
An entity primarily responsible for making the resource
Machelska H; Stein C
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1213/00000539-200210000-00039" target="_blank" rel="noreferrer">10.1213/00000539-200210000-00039</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2002
2002
Analgesics
Anesthesia & Analgesia
Animals
Backlog
Cellular/physiology
Endorphins/metabolism
Humans
Immune System/physiology
Immunity
Journal Article
Machelska H
Non-U.S. Gov't
Opioid/pharmacology
Opioid/physiology
Pain/drug therapy/immunology/pathology
Receptors
Research Support
Stein C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/jlb.58.2.137" target="_blank" rel="noreferrer">http://doi.org/10.1002/jlb.58.2.137</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Associations between the neuroendocrine and immune systems
Publisher
An entity responsible for making the resource available
Journal Of Leukocyte Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
Subject
The topic of the resource
Humans; Animals; Biomarkers of Pain; Cell Communication; Cytokines/physiology; Hormones/physiology; Hypothalamo-Hypophyseal System/physiology; Immune System/physiology; Interleukins/physiology; Leukocytes/physiology; Neurosecretory Systems/physiology; Signal Transduction
Creator
An entity primarily responsible for making the resource
Weigent DA; Blalock JE
Description
An account of the resource
Organisms respond to infection with complex adaptations involving bidirectional communication between the immune and neuroendocrine systems. The idea of intercellular communication between the neuroendocrine and immune systems via common signal molecules has provided a conceptual framework for such crosstalk. The studies to date show that cells of the immune system contain receptors for neuroendocrine hormones and can also be considered a source of pituitary and hypothalamic peptides. The structure and pattern of synthesis of these peptides by leukocytes appear similar to neuroendocrine hormones, although some differences exist. Once secreted, these peptide hormones may function as endogenous regulators of the immune system as well as conveyors of information from the immune to the neuroendocrine system. The plasma hormone concentrations contributed by lymphocytes usually do not reach the levels required when the pituitary gland is the source, but because immune cells are mobile, they have the potential to locally deposit the hormone at the target site. Likewise, other studies show that cells of the neuroendocrine system contain receptors for cytokines and can also be considered a source of cytokines, particularly interleukin-1 (IL-1) and IL-6. In the pituitary IL-1 beta coexists with thyroid stimulating hormone in a subpopulation of thyrotropes, suggesting it may have a role as a pituitary paracrine factor. The cytokines, including IL-1, IL-2, IL-6, interferon-gamma, and tumor necrosis factor, exert profound effects on hypothalamic pituitary axes. It is our hypothesis that the relay of information to the neuroendocrine system represents a sensory function for the immune system wherein leukocytes recognize stimuli that are not recognizable by the central and peripheral nervous systems (i.e., bacteria, tumors, viruses, and antigens). The recognition of such noncognitive stimuli by immunocytes is then converted into information and a physiological change occurs. Future studies into the physiological role that cytokines and neuroendocrine hormones have in these systems will be of considerable interest for both immunologists and endocrinologists.
1995
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jlb.58.2.137" target="_blank" rel="noreferrer">10.1002/jlb.58.2.137</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1995
Animals
Backlog
Biomarkers of Pain
Blalock JE
Cell Communication
Cytokines/physiology
Hormones/physiology
Humans
Hypothalamo-Hypophyseal System/physiology
Immune System/physiology
Interleukins/physiology
Journal Article
Journal Of Leukocyte Biology
Leukocytes/physiology
Neurosecretory Systems/physiology
Signal Transduction
Weigent DA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejm199801153380307" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejm199801153380307</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Protective and damaging effects of stress mediators
Publisher
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The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Humans; Adaptation; Biomarkers of Pain; Brain/physiology; Immune System/physiology; Homeostasis; Physiological; Stress/physiopathology; Cardiovascular Physiology
Creator
An entity primarily responsible for making the resource
McEwen BS
Identifier
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<a href="http://doi.org/10.1056/nejm199801153380307" target="_blank" rel="noreferrer">10.1056/nejm199801153380307</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
1998
1998
Adaptation
Backlog
Biomarkers of Pain
Brain/physiology
Cardiovascular Physiology
Homeostasis
Humans
Immune System/physiology
Journal Article
McEwen BS
Physiological
Stress/physiopathology
The New England Journal Of Medicine
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
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URL Address
<a href="http://doi.org/10.1111/j.1749-6632.1999.tb08673.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1749-6632.1999.tb08673.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Proopiomelanocortin and the immune-neuroendocrine connection
Publisher
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Annals Of The New York Academy Of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
Subject
The topic of the resource
Humans; Animals; Molecular Sequence Data; Biomarkers of Pain; Interleukin-1/physiology; Base Sequence; Immune System/physiology; Neurosecretory Systems/physiology; Neuroimmunomodulation/physiology; Amino Acid Sequence; Biomarkers Reference List; Pro-Opiomelanocortin/genetics/physiology
Creator
An entity primarily responsible for making the resource
Blalock JE
Description
An account of the resource
This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular understanding of neuroimmunomodulation. This, together with the presence of opiate and ACTH receptors on lymphocytes and macrophages, provided the first biochemical circuit for which the same signal molecules and receptors could be used for intrasystem regulation, as well as bidirectional communication between the immune and neuroendocrine systems. Today we have a quite good understanding of the regulation and processing of POMC in immune cells, as well as the interaction of its product peptides with other cytokines. For instance, IL-1 causes POMC production by immune cells, and the POMC product, alpha-MSH, in turn, acts functionally as an IL-1 antagonist. In the past year, the expression of full-length POMC mRNA has been reported and this solved one of the paradoxes with respect to POMC production, processing, and secretion. We provide data on these developments together with quite startling findings on the physiologic function of POMC peptides in the immune system. Among these are the local antinociceptive effects of immune cell-derived beta-endorphin, altered hematopoiesis in opiate receptor-deficient animals, and the diagnosis of ACTH insensitivity by a deficiency of ACTH receptors on lymphocytes.
1999
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1749-6632.1999.tb08673.x" target="_blank" rel="noreferrer">10.1111/j.1749-6632.1999.tb08673.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1999
Amino Acid Sequence
Animals
Annals Of The New York Academy Of Sciences
Backlog
Base Sequence
Biomarkers of Pain
Biomarkers Reference List
Blalock JE
Humans
Immune System/physiology
Interleukin-1/physiology
Journal Article
Molecular Sequence Data
Neuroimmunomodulation/physiology
Neurosecretory Systems/physiology
Pro-Opiomelanocortin/genetics/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
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URL Address
<a href="http://doi.org/10.3181/00379727-198-43309b" target="_blank" rel="noreferrer">http://doi.org/10.3181/00379727-198-43309b</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of endogenous opioids and their receptors in the immune system
Publisher
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Proceedings Of The Society For Experimental Biology And Medicine (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
Subject
The topic of the resource
Humans; Animals; Biomarkers of Pain; Receptors; Immune System/physiology; Endorphins/physiology; Opioid/physiology; Immunity
Creator
An entity primarily responsible for making the resource
Carr DJ
Description
An account of the resource
Opioid peptides appear to be dynamic signaling molecules that are produced within the immune system and are active regulators of an immune response. Furthermore, the receptors for these peptides occurring on immunocyte membranes share characteristics with neuronal opioid receptors, including molecular size, immunogenicity, and the use of specific intracellular signaling pathways. Recent studies of the interaction of opioids with cytokines have indicated that opioid peptides are intimately involved within the immune system. Specifically, opioids, including 2-n-pentyloxy-2-phenyl-4-methyl-morpholine, naloxone, and beta-endorphin, have been shown to interact with IL-2 receptors (134) and regulate production of IL-1 and IL-2 (48-50, 135). Conversely, IL-1 has been shown to up-regulate opioid peptide binding in brain tissue (136). Furthermore, the induction of IL-1 by opioids has also been identified in the invertebrate Mytilus, indicating the evolutionary conservation of this relationship (137). These results seem to typify the intricate association between the immune and neuroendocrine systems through opioid pathways. It is predicted that future endeavors will use this relationship to diagnose and treat specific diseases that have at their basis neuroendocrine and immunologic imbalances.
1991
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3181/00379727-198-43309b" target="_blank" rel="noreferrer">10.3181/00379727-198-43309b</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1991
Animals
Backlog
Biomarkers of Pain
Carr DJ
Endorphins/physiology
Humans
Immune System/physiology
Immunity
Journal Article
Opioid/physiology
Proceedings Of The Society For Experimental Biology And Medicine (New York, N.Y.)
Receptors