1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11723390" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=11723390</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An update on the leukodsytrophies Publisher An entity responsible for making the resource available Current Opinion In Neurology Date A point or period of time associated with an event in the lifecycle of the resource 2001 Subject The topic of the resource Child; Adult; P.H.S.; U.S. Gov't; Brain Diseases; Diagnosis; Differential; Human; Metabolic; Support; Diseases/diagnosis/genetics; Glial Fibrillary Acidic Protein/genetics; Hereditary Central Nervous System Demyelinating; Inborn/diagnosis/genetics; Myelin Proteolipid Protein/genetics Creator An entity primarily responsible for making the resource Schiffmann R; Boespflug-Tanguy O Description An account of the resource This review centers on important recent advances in the understanding of the role of glial fibrillary acidic protein in Alexander disease and of proteolipid protein in hypomyelinating disorders such as Pelizaeus-Merzbacher and spastic paraplegia. We also describe seven novel leukodystrophies. These include childhood ataxia with central nervous system hypomyelination, a relatively common leukodystrophy syndrome with linkage to chromosome 3 in some patients, and megalencephalic leukoencephalopathy with subcortical cysts whose gene has recently been cloned. These, along with five other disorders, including leukodystrophy with polyol metabolism abnormality, demonstrate that an increasing number of protein and metabolic abnormalities can cause primary myelin disorders. 2001 Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2001 Adult Backlog Boespflug-Tanguy O Brain Diseases Child Current Opinion in Neurology Diagnosis Differential Diseases/diagnosis/genetics Glial Fibrillary Acidic Protein/genetics Hereditary Central Nervous System Demyelinating Human Inborn/diagnosis/genetics Journal Article Metabolic Myelin Proteolipid Protein/genetics P.H.S. Schiffmann R Support U.S. Gov't