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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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URL Address
<a href="http://doi.org/10.1016/j.cell.2010.09.047" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.cell.2010.09.047</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha2delta3 as an Evolutionarily Conserved Pain Gene
Publisher
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Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
Subject
The topic of the resource
Biomarkers of Pain
Creator
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Neely GG; Hess A; Costigan M; Keene AC; Goulas S; Langeslag M; Griffin RS; Belfer I; Dai F; Smith SB; Diatchenko L; Gupta V; Xia CP; Amann S; Kreitz S; Heindl-Erdmann C; Wolz S; Ly CV; Arora S; Sarangi R; Dan D; Novatchkova M; Rosenzweig M; Gibson DG; Truong D; Schramek D; Zoranovic T; Cronin SJ; Angjeli B; Brune K; Dietzl G; Maixner W; Meixner A; Thomas W; Pospisilik JA; Alenius M; Kress M; Subramaniam S; Garrity PA; Bellen HJ; Woolf CJ; Penninger JM
Description
An account of the resource
Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha2delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha2delta3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha2delta3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha2delta3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.
2010
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cell.2010.09.047" target="_blank" rel="noreferrer">10.1016/j.cell.2010.09.047</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2010
Alenius M
Amann S
Angjeli B
Arora S
Backlog
Belfer I
Bellen HJ
Biomarkers of Pain
Brune K
Cell
Costigan M
Cronin SJ
Dai F
Dan D
Diatchenko L
Dietzl G
Garrity PA
Gibson DG
Goulas S
Griffin RS
Gupta V
Heindl-Erdmann C
Hess A
Journal Article
Keene AC
Kreitz S
Kress M
Langeslag M
Ly CV
Maixner W
Meixner A
Neely GG
Novatchkova M
Penninger JM
Pospisilik JA
Rosenzweig M
Sarangi R
Schramek D
Smith SB
Subramaniam S
Thomas W
Truong D
Wolz S
Woolf CJ
Xia CP
Zoranovic T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1007/bf02828121" target="_blank" rel="noreferrer">http://doi.org/10.1007/bf02828121</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Leigh's syndrome
Publisher
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Indian Journal Of Pediatrics
Date
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2004
Subject
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Female; Humans; Disease Progression; Autopsy; Severity of Illness Index; Risk Assessment; Biopsy; Magnetic Resonance Imaging; Fatal Outcome; infant; Q3 Literature Search; Needle; Basal Ganglia/pathology; Immunohistochemistry; Leigh Disease/diagnosis/physiopathology/therapy
Creator
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Mannan AA; Sharma MC; Shrivastava P; Ralte AM; Gupta V; Behari M; Sarkar C
Description
An account of the resource
A 15-month-old female child presented with sudden onset cough and hyperventilation along with evidence of metabolic acidosis. She had past history of recurrent vomiting, episodes of abnormal posturing, difficulty in deglutition and regression of milestones since 12 months of age. CT scan of the brain revealed hypodense lesions in bilateral basal ganglia and on MRI there were T2 hyperintensities in bilateral lentiform nuclei, caudate nuclei, thalamus, red nuclei and dentate nuclei. Biochemical examination revealed persistently elevated serum lactate levels with high lactate/pyruvate ratio. Resuscitative measures were of no avail and the child succumbed to the illness on the second day of admission. Neuropathological examination at autopsy demonstrated marked spongiosis, focal necrosis, endothelial proliferation, reactive astrogliosis and extensive demyelination involving bilateral basal ganglia, midbrain and spinal cord which were typical of Leigh's sub acute necrotizing encephalomyelopathy.
2004
Identifier
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<a href="http://doi.org/10.1007/bf02828121" target="_blank" rel="noreferrer">10.1007/bf02828121</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2004
Autopsy
Backlog
Basal Ganglia/pathology
Behari M
Biopsy
Disease Progression
Fatal Outcome
Female
Gupta V
Humans
Immunohistochemistry
Indian Journal Of Pediatrics
Infant
Journal Article
Leigh Disease/diagnosis/physiopathology/therapy
Magnetic Resonance Imaging
Mannan AA
Needle
Q3 Scoping Review Results
Ralte AM
Risk Assessment
Sarkar C
Severity Of Illness Index
Sharma MC
Shrivastava P