1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Citation List Month Backlog URL Address <a href="http://doi.org/10.1136/adc.2004.065482" target="_blank" rel="noreferrer">http://doi.org/10.1136/adc.2004.065482</a> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sleep disturbance in Sanfilippo syndrome: a parental questionnaire study Publisher An entity responsible for making the resource available Archives Of Disease In Childhood Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Child; Humans; infant; Adult; Questionnaires; Treatment Outcome; Incidence; Behavior Therapy; adolescent; Preschool; infant; Q3 Literature Search; Newborn; Age of Onset; Melatonin/therapeutic use; Mucopolysaccharidosis III/psychology; Sleep Disorders/epidemiology/etiology/therapy Creator An entity primarily responsible for making the resource Fraser J; Gason AA; Wraith JE; Delatycki MB Description An account of the resource AIMS: To determine the incidence, manifestations, and best management of sleep disturbance in Sanfilippo syndrome (mucopolysaccharidosis (MPS) type III). METHODS: Families were ascertained through the MPS societies of Australasia, the UK, and the USA. Questionnaires were sent by mail and were answered anonymously. Identical questions regarding sleep disturbance were asked about unaffected siblings to provide control data. Sleep disturbance was quantified by a total sleep disturbance score. RESULTS: A total of 141 responses were received; 91.5% of children with Sanfilippo syndrome had sleep disturbance and this was significantly higher than for their unaffected sibs; 77.5% of parents had used medication for this problem, with melatonin and antihistamines being most commonly used. Melatonin and benzodiazepines were reported as the most efficacious. Many different environmental modifications had been employed for this problem and some parents reported success with behavioural therapies. CONCLUSIONS: Sleep disturbance is common, severe, and difficult to manage in Sanfilippo syndrome. Based on the parental responses and its safety profile, melatonin is the first line drug that should be tried. Behavioural therapy should be tried in all with Sanfilippo syndrome and sleep disturbance. 2005 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1136/adc.2004.065482" target="_blank" rel="noreferrer">10.1136/adc.2004.065482</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s). Type The nature or genre of the resource Journal Article 2005 Adolescent Adult Age of Onset Archives of Disease in Childhood Backlog Behavior Therapy Child Delatycki MB Fraser J Gason AA Humans Incidence Infant Journal Article Melatonin/therapeutic use Mucopolysaccharidosis III/psychology Newborn Preschool Q3 Scoping Review Results Questionnaires Sleep Disorders/epidemiology/etiology/therapy Treatment Outcome Wraith JE