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Text
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URL Address
<a href="http://doi.org/10.1136/jnnp.74.4.495" target="_blank" rel="noreferrer">http://doi.org/10.1136/jnnp.74.4.495</a>
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Title
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Beta endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis
Publisher
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Journal Of Neurology, Neurosurgery, And Psychiatry
Date
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2003
Subject
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Female; Humans; Male; Adult; Middle Aged; Magnetic Resonance Imaging; Phenotype; Biomarkers of Pain; Brain/pathology; Leukocytes; Mononuclear/chemistry; beta-Endorphin/blood/genetics; Multiple Sclerosis/blood/genetics/pathology
Creator
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Gironi M; Furlan R; Rovaris M; Comi G; Filippi M; Panerai AE; Sacerdote P
Description
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The possible link between the opioid peptide beta endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of beta endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest beta endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. Average beta endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that beta endorphin may have a role in the downregulation of the inflammatory process.
2003
Identifier
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<a href="http://doi.org/10.1136/jnnp.74.4.495" target="_blank" rel="noreferrer">10.1136/jnnp.74.4.495</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2003
Adult
Backlog
beta-Endorphin/blood/genetics
Biomarkers of Pain
Brain/pathology
Comi G
Female
Filippi M
Furlan R
Gironi M
Humans
Journal Article
Journal Of Neurology, Neurosurgery, And Psychiatry
Leukocytes
Magnetic Resonance Imaging
Male
Middle Aged
Mononuclear/chemistry
Multiple Sclerosis/blood/genetics/pathology
Panerai AE
Phenotype
Rovaris M
Sacerdote P