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Text
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<a href="http://doi.org/10.1016/j.healun.2004.07.016" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.healun.2004.07.016</a>
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Title
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Safety and efficacy of rosuvastatin therapy for the prevention of hyperlipidemia in adult cardiac transplant recipients
Publisher
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The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation
Date
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2005
Subject
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Female; Humans; Male; Survival Rate; Cohort Studies; Follow-Up Studies; Prospective Studies; Aged; Middle Aged; Treatment Outcome; Risk Assessment; Drug Administration Schedule; 80 and over; Comparative Study; Dose-Response Relationship; Drug; Graft Survival; control; dosage; Fluorobenzenes/administration &; Graft Rejection; Heart Transplantation/adverse effects/methods; Hyperlipidemia/drug therapy/prevention &; Postoperative Complications/prevention &; Pyrimidines/administration &; Sulfonamides/administration &
Creator
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Samman A; Imai C; Straatman L; Frolich J; Humphries K; Ignaszewski A
Description
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BACKGROUND: Hyperlipidemia after orthotopic heart transplantation (OHT) is associated with immunosuppression. Many OHT patients have increased lipid levels above published guidelines despite treatment with high doses of statins. Treatment with rosuvastatin (ROS) in OHT patients has not yet been evaluated. Therefore, we assessed its efficacy and safety in an OHT population. METHODS: Twenty-one OHT recipients, median age 66 years, whose lipid levels were sub-optimal on the highest tolerated doses of statins, received ROS in addition to standard immunosuppression. Total cholesterol (TC), low-density lipoprotein (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), liver transaminases (AST) and creatinine kinase (CK) were measured before and during treatment with ROS. RESULTS: After 6 weeks on an average ROS dose of 10 mg/day, a TC:HDL-C ratio of <4 was reached in 76% of patients, and 70% of patients reached an LDL-C level of <2.5 mmol/liter (100 mg/dl). TC decreased to <5.2 mmol/liter (200 mg/dl) in 80% of patients and TG decreased to <2 mmol/liter (175 mg/dl) in 61% of patients. Except for the HDL-C increase, all changes were statistically significant. The decrease in the median TC:HDL-C ratio between baseline and 6 weeks was also statistically significant (p = 0.001). There were no significant changes in CK or AST levels, and no clinical evidence of myositis. One patient developed myalgia and 2 were withdrawn from the study because of mild elevation of CK (<3-fold upper limit of normal [ULN]). CONCLUSIONS: In the setting of tertiary referral centers, ROS appears to be safe and effective in lowering LDL-C in OHT recipients in whom treatment with other statins failed to achieve target LDL-C. No evidence of liver or muscle dysfunction was noted. Long-term studies are needed to ascertain the effect of ROS therapy on incidence of coronary artery disease (CAD) in this population.
2005
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<a href="http://doi.org/10.1016/j.healun.2004.07.016" target="_blank" rel="noreferrer">10.1016/j.healun.2004.07.016</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2005
80 And Over
Aged
Backlog
Cohort Studies
Comparative Study
Control
dosage
Dose-Response Relationship
Drug
Drug Administration Schedule
Female
Fluorobenzenes/administration &
Follow-up Studies
Frolich J
Graft Rejection
Graft Survival
Heart Transplantation/adverse effects/methods
Humans
Humphries K
Hyperlipidemia/drug therapy/prevention &
Ignaszewski A
Imai C
Journal Article
Male
Middle Aged
Postoperative Complications/prevention &
Prospective Studies
Pyrimidines/administration &
Risk Assessment
Samman A
Straatman L
Sulfonamides/administration &
Survival Rate
The Journal Of Heart And Lung Transplantation : The Official Publication Of The International Society For Heart Transplantation
Treatment Outcome