Bisphosphonates: mechanisms of action
Humans; Animals; Clodronate; Diphosphonates/chemistry/metabolism/pharmacology; Bone Development/drug effects; Bone Resorption/physiopathology
1998
Fleisch H
Endocrine Reviews
1998
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1210/er.19.1.80" target="_blank" rel="noreferrer">10.1210/er.19.1.80</a>
Diphosphonates in the treatment of myositis ossificans
Child; Humans; Male; Depression; adolescent; Preschool; infant; Clodronate; Calcium/metabolism; Chemical; Myositis Ossificans/drug therapy/metabolism; Phosphonic Acids/therapeutic use
1969
Bassett CA; Donath A; Macagno F; Preisig R; Fleisch H; Francis MD
Lancet
1969
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/s0140-6736(69)92293-4" target="_blank" rel="noreferrer">10.1016/s0140-6736(69)92293-4</a>
Diphosphonates: history and mechanisms of action
Humans; Animals; Non-U.S. Gov't; Research Support; Clodronate; Bone Resorption/drug effects; Calcification; Calcinosis/drug therapy; Calcium Phosphates/metabolism; Clodronic Acid; Diphosphates/pharmacology; Diphosphonates/metabolism/pharmacology/therapeutic use; Etidronic Acid/pharmacology; Methylene Chloride; Physiologic/drug effects; Polyphosphates/pharmacology
The history of diphosphonates began with studies of inorganic pyrophosphate. This compound was found to occur in many biological fluids and inhibited the precipitation of calcium phosphates. It also slowed the transformation of amorphous calcium phosphate to its crystalline form, and inhibited crystal aggregation and dissolution. These observations suggested that it might be a compound of physiological or pathophysiological significance, perhaps in hypophosphatasia and in renal lithiasis. Diphosphonates are compounds where the P-O-P bond of pyrophosphate is replaced by a P-C-P bond. Many diphosphonates have been synthesized and tested and some relationship of their structure to the spectrum of biological effects has been observed. These analogues have similar properties to pyrophosphate, but unlike pyrophosphate they are resistant to enzymic degradation. Their experimental properties have led to their clinical development as bone scanning agents and in the treatment of disorders of ectopic mineralization and increased bone resorption.
1981
Fleisch H
Metabolic Bone Disease & Related Research
1981
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Journal Article
<a href="http://doi.org/10.1016/0221-8747(81)90044-8" target="_blank" rel="noreferrer">10.1016/0221-8747(81)90044-8</a>