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Dublin Core
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Title
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Oncology
Text
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Citation List Month
Oncology 2017 List
URL Address
<a href="http://doi.org/10.1002/pbc.26589" target="_blank" rel="noreferrer">http://doi.org/10.1002/pbc.26589</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Practice patterns of palliative radiation therapy in pediatric oncology patients in an international pediatric research consortium
Publisher
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Pediatric Blood And Cancer
Date
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2017
Subject
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Childhood Cancer/rt [radiotherapy]; Palliative Therapy; Anesthesia; Article; Brain Metastasis; Cancer Patient; Child; Cone Beam Computed Tomography; Conformal Radiotherapy; Electron Therapy; Ependymoma; Ewing Sarcoma; Health Survey; Histopathology; Human; Intensity Modulated Radiation Therapy; Intestine Obstruction; Leukemia; Lymphoma; Major Clinical Study; Malignant Neoplasm; Medulloblastoma; Metastasis; Neuroblastoma; Osteosarcoma; Pain; Primary Tumor; Priority Journal; Proton Therapy; Radiation Dose Fractionation; Radiosensitivity; Re-irradiation; Respiratory Tract Disease; Rhabdomyosarcoma; Spinal Cord Compression; Stereotactic Body Radiation Therapy; Stomach Distension
Creator
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Rao AD; Chen Q; Ermoian RP; Alcorn SR; Figueiredo MLS; Chen MJ; Dieckmann K; MacDonald SM; Ladra MM; Kobyzeva D; Nechesnyuk AV; Nilsson K; Ford EC; Winey BA; Villar RC; Terezakis SA
Description
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Background/Objectives: The practice of palliative radiation therapy (RT) is based on extrapolation from adult literature. We evaluated patterns of pediatric palliative RT to describe regimens used to identify opportunity for future pediatric-specific clinical trials. Design/Methods: Six international institutions with pediatric expertise completed a 122-item survey evaluating patterns of palliative RT for patients <=21 years old from 2010 to 2015. Two institutions use proton RT. Palliative RT was defined as treatment with the goal of symptom control or prevention of immediate life-threatening progression. Results: Of 3,225 pediatric patients, 365 (11%) were treated with palliative intent to a total of 427 disease sites. Anesthesia was required in 10% of patients. Treatment was delivered to metastatic disease in 54% of patients. Histologies included neuroblastoma (30%), osteosarcoma (18%), leukemia/lymphoma (12%), rhabdomyosarcoma (12%), medulloblastoma/ependymoma (12%), Ewing sarcoma (8%), and other (8%). Indications included pain (43%), intracranial symptoms (23%), respiratory compromise (14%), cord compression (8%), and abdominal distention (6%). Sites included nonspine bone (35%), brain (16% primary tumors, 6% metastases), abdomen/pelvis (15%), spine (12%), head/neck (9%), and lung/mediastinum (5%). Re-irradiation comprised 16% of cases. Techniques employed three-dimensional conformal RT (41%), intensity-modulated RT (23%), conventional RT (26%), stereotactic body RT (6%), protons (1%), electrons (1%), and other (2%). The most common physician-reported barrier to consideration of palliative RT was the concern about treatment toxicity (83%). Conclusion: There is significant diversity of practice in pediatric palliative RT. Combined with ongoing research characterizing treatment response and toxicity, these data will inform the design of forthcoming clinical trials to establish effective regimens and minimize treatment toxicity for this patient population.
Identifier
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<a href="http://doi.org/10.1002/pbc.26589" target="_blank" rel="noreferrer">10.1002/pbc.26589</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Alcorn SR
Anesthesia
Article
Brain Metastasis
Cancer Patient
Chen MJ
Chen Q
Child
Childhood Cancer/rt [radiotherapy]
Cone Beam Computed Tomography
Conformal Radiotherapy
Dieckmann K
Electron Therapy
Ependymoma
Ermoian RP
Ewing Sarcoma
Figueiredo MLS
Ford EC
Health Survey
Histopathology
Human
Intensity Modulated Radiation Therapy
Intestine Obstruction
Kobyzeva D
Ladra MM
Leukemia
Lymphoma
MacDonald SM
Major Clinical Study
Malignant Neoplasm
Medulloblastoma
Metastasis
Nechesnyuk AV
Neuroblastoma
Nilsson K
Oncology 2017 List
Osteosarcoma
Pain
Palliative Therapy
Pediatric Blood and Cancer
Primary Tumor
Priority Journal
Proton Therapy
Radiation Dose Fractionation
Radiosensitivity
Rao AD
Re-irradiation
Respiratory Tract Disease
Rhabdomyosarcoma
Spinal Cord Compression
Stereotactic Body Radiation Therapy
Stomach Distension
Terezakis SA
Villar RC
Winey BA