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Text
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<a href="http://doi.org/10.1530/eje.0.1490079" target="_blank" rel="noreferrer">http://doi.org/10.1530/eje.0.1490079</a>
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Title
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Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions
Publisher
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European Journal Of Endocrinology
Date
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2003
Subject
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Female; Humans; Pregnancy; Animals; Biomarkers of Pain; Nervous System Diseases/physiopathology; Neuropeptides/metabolism; Pro-Opiomelanocortin/biosynthesis/genetics/physiology
Creator
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Raffin-Sanson ML; de Keyzer Y; Bertagna X
Description
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Proopiomelanocortin (POMC) is the polypeptide precursor of ACTH. First discovered in anterior pituitary corticotroph cells, it has more recently been revealed to have many other physiological aspects. The fine molecular mechanisms of ACTH biosynthesis show that ACTH is but one piece of a puzzle which contains many other peptides. Present in various tIssues, among which are pituitary, hypothalamus, central nervous system and skin, POMC undergoes extensive post-translational processing. This processing is tIssue-specific and generates, depending on the case, various sets of peptides involved in completely diverse biological functions. POMC expressed in corticotroph cells of the pituitary is necessary for adrenal function. Recent developments have shown that POMC-expressing neurons in the brain play a major role in the control of pain and energy homeostasis. Local production of POMC-derived peptides in skin may influence melanogenesis. A still unknown function in the placenta is likely.POMC has become a paradigmatic polypeptide precursor model illustrating the variable roles of a single gene and its various products in different localities.
2003
Identifier
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<a href="http://doi.org/10.1530/eje.0.1490079" target="_blank" rel="noreferrer">10.1530/eje.0.1490079</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2003
Animals
Backlog
Bertagna X
Biomarkers of Pain
de Keyzer Y
European Journal Of Endocrinology
Female
Humans
Journal Article
Nervous System Diseases/physiopathology
Neuropeptides/metabolism
Pregnancy
Pro-Opiomelanocortin/biosynthesis/genetics/physiology
Raffin-Sanson ML