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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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URL Address
<a href="http://doi.org/10.1002/ajmg.a.31169" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajmg.a.31169</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Behavioral and temperamental features of children with Costello syndrome
Publisher
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American Journal of Medical Genetics Part A
Date
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2006
Subject
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Male; Child Behavior; Child; Humans; Female; Child Preschool; Syndrome; Linear Models; Abnormalities Multiple/px [Psychology]; Temperament; Abnormalities Multiple/ge [Genetics]; Abnormalities Multiple/pa [Pathology]; Aggression/px [Psychology]; Developmental Disabilities/pa [Pathology]; Face/ab [Abnormalities]; Growth Disorders/pa [Pathology]; Juvenile Delinquency/px [Psychology]; Shyness; behavioral problems; Costello syndrome; trajectory; characteristics; internalizing problems
Creator
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Galera C; Delrue M A; Goizet C; Etchegoyhen K; Taupiac E; Sigaudy S; Arveiler B; Philip N; Bouvard M; Lacombe D
Description
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Costello syndrome (CS) is a rare genetic condition due to germline mutations in HRAS proto-oncogene and characterized by increased birth weight, postnatal growth retardation, distinctive facial appearance, typical medical problems (including feeding problems in the neonatal period), cutaneous anomalies, and developmental delay. Outgoing personality has often been noted in case reports, but few studies have focused specifically on the behavioral aspects of CS. A preliminary survey described irritability in younger patients with improvement between age 2 and 4, but a standardized psychometric tool was not used. A second study using the Child Behavior Checklist (CBCL) showed relatively high (albeit subclinical) levels of internalizing problems. These descriptive investigations lacked a control group. We describe a comparative survey to evaluate the behavioral and temperamental features of children with CS. We conducted a cross-sectional assessment using the CBCL and the Emotionality, Activity, Shyness, Sociability (EAS) temperament questionnaire to evaluate behavior and temperament in 11 CS children (2 years 5 months to 9 years) comparing them to 33 gender- and age-matched children without disability. The results suggest that the high levels of internalizing problems found before age 4 in CS patients might decrease with age. They also point to possible "hyperemotionality." Further studies using a larger sample size and IQ-matched control groups are needed to more accurately characterize individuals with this rare syndrome.Copyright 2006 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/ajmg.a.31169" target="_blank" rel="noreferrer noopener">10.1002/ajmg.a.31169</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Abnormalities Multiple/ge [Genetics]
Abnormalities Multiple/pa [Pathology]
Abnormalities Multiple/px [Psychology]
Aggression/px [Psychology]
American Journal of Medical Genetics Part A
Arveiler B
behavioral problems
Bouvard M
characteristics
Child
Child Preschool
Child Behavior
costello syndrome
Delrue M A
Developmental Disabilities/pa [Pathology]
Etchegoyhen K
Face/ab [Abnormalities]
Female
Galera C
Goizet C
Growth Disorders/pa [Pathology]
Humans
internalizing problems
Juvenile Delinquency/px [Psychology]
Lacombe D
Linear Models
Male
Philip N
Shyness
Sigaudy S
Syndrome
Taupiac E
Temperament
Trajectory