1
40
5
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0304-3959(99)00267-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0304-3959(99)00267-5</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Humans; Cohort Studies; Death; Disease Progression; Risk Assessment; Non-U.S. Gov't; Research Support; Models; Statistical; Anti-Inflammatory Agents; Databases; Factual; Digestive System; Endoscopy; Gastrointestinal Hemorrhage/chemically induced/mortality; Non-Steroidal/adverse effects; Peptic Ulcer Perforation/chemically induced/mortality
Creator
An entity primarily responsible for making the resource
Tramer MR; Moore RA; Reynolds DJ; McQuay HJ
Description
An account of the resource
Randomised controlled trials (RCTs) alone are unlikely to provide reliable estimates of the incidence of rare events because of their limited size. Cohort, case control, and other observational studies have large numbers but are vulnerable to various kinds of bias. Wanting to estimate the risk of death from bleeding or perforated gastroduodenal ulcers with chronic usage of non-steroidal anti-inflammatory drugs (NSAIDs) with greater precision, we developed a model to quantify the frequency of rare adverse events which follow a biological progression. The model combined data from both RCTs and observational studies. We searched systematically for any report of chronic (>/=2 months) use of NSAIDs which gave information on gastroduodenal ulcer, bleed or perforation, death due to these complications, or progression from one level of harm to the next. Fifteen RCTs (19364 patients exposed to NSAIDs for 2-60 months), three cohort studies (215076 patients redeeming a NSAID prescription over a 3-12 month period), six case-control studies (2957 cases) and 20 case series (7406), and case reports (4447) were analysed. In RCTs the incidence of bleeding or perforation in 6822 patients exposed to NSAIDs was 0.69%; two deaths occurred. Of 11040 patients with bleeding or perforation with or without NSAID exposure across all reports, 6-16% (average 12%) died; the risk was lowest in RCTs and highest in case reports. Death from bleeding or perforation in all controls not exposed to NSAIDs occurred in 18 out of 849489 (0.002%). From these numbers we calculated the number-needed-to-treat for one patient to die due to gastroduodenal complications with chronic (>/=2 months) NSAIDs as 1/((0.69x inverted question mark6-16%, average 12% inverted question mark)-0.002%))=909-2500 (average 1220). On average 1 in 1200 patients taking NSAIDs for at least 2 months will die from gastroduodenal complications who would not have died had they not taken NSAIDs. This extrapolates to about 2000 deaths each year in the UK.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3959(99)00267-5" target="_blank" rel="noreferrer">10.1016/s0304-3959(99)00267-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Anti-Inflammatory Agents
Backlog
Cohort Studies
Databases
Death
Digestive System
Disease Progression
Endoscopy
Factual
Gastrointestinal Hemorrhage/chemically induced/mortality
Humans
Journal Article
McQuay HJ
Models
Moore RA
Non-Steroidal/adverse effects
Non-U.S. Gov't
Pain
Peptic Ulcer Perforation/chemically induced/mortality
Research Support
Reynolds DJ
Risk Assessment
statistical
Tramer MR
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1053/jpsu.2002.30267" target="_blank" rel="noreferrer">http://doi.org/10.1053/jpsu.2002.30267</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quantitative and qualitative analysis of gastroesophageal reflux after percutaneous endoscopic gastrostomy
Publisher
An entity responsible for making the resource available
Journal Of Pediatric Surgery
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Child; Female; Humans; Male; Hydrogen-Ion Concentration; Acute Disease; quality of life; Preschool; Enteral Nutrition/methods; Weight Gain; Monitoring; Endoscopy; Airway Obstruction/diagnosis; Gastroesophageal Reflux/epidemiology/etiology/therapy; Gastrointestinal/adverse effects/methods; Gastrostomy/adverse effects/methods; Nervous System Diseases/rehabilitation; Physiologic/methods/statistics & numerical data; Postoperative Complications/diagnosis/epidemiology/etiology; Vomiting/diagnosis
Creator
An entity primarily responsible for making the resource
Samuel M; Holmes K
Description
An account of the resource
BACKGROUND/PURPOSE: Percutaneous endoscopic gastrostomy (PEG) is of great benefit to a defined population of children, but gastrostomy has been implicated in causation or exacerbation of gastroesophageal reflux (GER). The aim of this study was to quantitatively and qualitatively analyze the effect of PEG on GER. METHODS AND MATERIAL: Sixty-four children mean age 6.7 +/- 4.2 years, most of whom were impaired neurologically were evaluated for GER after PEG between 1998 and 2000. Twenty-four-hour pH monitoring was used for quantitative assessment. Qualitative analysis was by interview to record the following: vomiting, choking, chest infection, and weight gain. RESULTS: Twenty-four hour pH monitoring was performed 9.4 +/- 1.2 weeks after PEG. Patients underwent follow-up for 18 +/- 6 months. Seventy-two percent who did not have reflux before PEG remained reflux free. Fourteen percent who had GER before PEG continued to have reflux (P .05). Six percent of patients with preexisting GER improved post-PEG. Of the 14 patients (22%) who had or continued to have reflux after PEG, 11 of 14 (79%) underwent antireflux surgery, and 21% were managed successfully by intensive medical treatment and change of feeding regimen. Only 6% experienced difficulties and complications with the device. Forty-eight percent of patients did not vomit pre- or postoperation. In 16%, vomiting improved post-PEG, whereas 14% experienced minor deterioration (1 to 2 vomits per month). Major deterioration was experienced by 22%. Weight gain occurred in 77%, and in 23% there was no loss of weight. There was an overall improvement in quality of life in 88% after PEG. Overall improvement in quality of life post-PEG, post-antireflux surgery and post-intensive medical management for pathologic GER was 94%. CONCLUSIONS: (1) PEG did not precipitate or exacerbate GER quantitatively or qualitatively in the majority of children. (2) A normal 24-hour pH study predicted a favourable outcome after PEG. (3) An abnormal preoperation pH study predicted persistence or worsening reflux after PEG, but not all of these patients required an antireflux procedure. (4) GER is not a contraindication to PEG, the overall benefits of which outweigh the risks.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1053/jpsu.2002.30267" target="_blank" rel="noreferrer">10.1053/jpsu.2002.30267</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Acute Disease
Airway Obstruction/diagnosis
Backlog
Child
Endoscopy
Enteral Nutrition/methods
Female
Gastroesophageal Reflux/epidemiology/etiology/therapy
Gastrointestinal/adverse effects/methods
Gastrostomy/adverse effects/methods
Holmes K
Humans
Hydrogen-Ion Concentration
Journal Article
Journal Of Pediatric Surgery
Male
Monitoring
Nervous System Diseases/rehabilitation
Physiologic/methods/statistics & numerical data
Postoperative Complications/diagnosis/epidemiology/etiology
Preschool
Quality Of Life
Samuel M
Vomiting/diagnosis
Weight Gain
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1440-1746.2005.03993.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1440-1746.2005.03993.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Morbidity and mortality after percutaneous endoscopic gastrostomy in children with neurological disability
Publisher
An entity responsible for making the resource available
Journal Of Gastroenterology And Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Child; Female; Humans; Male; Survival Rate; Adult; Treatment Outcome; Comorbidity; Survival Analysis; Risk Factors; Incidence; adolescent; Preschool; infant; Nutritional Failure; Australia/epidemiology; Endoscopy; Gastrointestinal/mortality; Gastrostomy/mortality; Malnutrition/mortality/prevention & control; Nervous System Diseases/mortality/surgery; Risk Assessment/methods
Creator
An entity primarily responsible for making the resource
Catto-Smith AG; Jimenez S
Description
An account of the resource
BACKGROUND AND AIM: Gastrostomy placement has become an integral mechanism for delivering nutritional support to children with severe neurological disability. Its impact on gastroesophageal reflux and mortality remains contentious. We examined the morbidity and long-term mortality of a group of children with severe neurological disability after percutaneous endoscopic gastrostomy (PEG). METHODS: We retrospectively identified all children with severe neurological disability who had a PEG at the Royal Children's Hospital in Melbourne between 1990 and 1997. Data were obtained from medical records. RESULTS: Ninety-eight children with neurological disability (M:F 1.8:1.0; median age 3.5 years, interquartile range 1.1-8.7 years) had an initial PEG in this period and were able to be followed for 6-14 years. As a group, they were underweight for their age with a Z score at PEG of -3.52 (SD 3.33), but had increased weight-for-age Z scores by 1.05 after a mean period of 6.1 months. Fourteen subsequently required fundoplication for reflux. Mortality rates were 11% after 1 year, 21% after 2 years, 27% after 3 years and 39% after 13 years. Mortality was increased in those children who were older at the time of PEG (P = 0.06). Gastroesophageal reflux, underweight-for-age and gender were not significantly related to mortality. CONCLUSION: Children with severe neurological dysfunction who require gastrostomy feeding have a substantial long-term mortality, but this may be unrelated to PEG placement.
2006
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1440-1746.2005.03993.x" target="_blank" rel="noreferrer">10.1111/j.1440-1746.2005.03993.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2006
Adolescent
Adult
Australia/epidemiology
Backlog
Catto-Smith AG
Child
Comorbidity
Endoscopy
Female
Gastrointestinal/mortality
Gastrostomy/mortality
Humans
Incidence
Infant
Jimenez S
Journal Article
Journal Of Gastroenterology And Hepatology
Male
Malnutrition/mortality/prevention & control
Nervous System Diseases/mortality/surgery
Nutritional Failure
Preschool
Risk Assessment/methods
Risk Factors
Survival Analysis
Survival Rate
Treatment Outcome
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ijporl.2015.11.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ijporl.2015.11.009</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Otorhinolaryngological, Audiovestibular and swallowing manifestations of patients with Niemann-Pick disease Type C
Publisher
An entity responsible for making the resource available
International Journal of Pediatric Otorhinolaryngology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
Subject
The topic of the resource
adolescent; hearing; dysphagia; priority journal; school child; preschool child; prospective study; human; article; child; female; male; controlled study; clinical article; auditory response; Balance disorders; body equilibrium; endoscopy; Flexible endoscopy; hearing impairment; Hearing problems; Niemann Pick disease/di [Diagnosis]; Niemann-Pick disease; otorhinolaryngology; pure tone audiometry; stabilography; swallowing; Swallowing disorders; vestibular system; feeding difficulties; tone and motor problems; NPC; penetration; aspiration scale; trajectory; characteristics; postural imbalance; dysphagia
Creator
An entity primarily responsible for making the resource
Senirli R T; Kuscu O; Akyol U; Topcu M; Yigit O; Aksoy S; Demir N
Description
An account of the resource
Objectives: The aim of this study is to evaluate audiovestibular and swallowing impairment of patients with NPC. Methods: Audiovestibular and swallowing evaluation were performed on patients with Niemann-Pick disease type C (NPC) at Hacettepe University between 20013 and 2015 prospectively. Pure-tone audiometry (PTA), Auditory Brain stem response (ABR), Flexible endoscopic evaluation of swallowing (FEES) test and posturography were done. Hearing, swallowing and balance states were measured. Results: There were 16 patients (5 male and 11 female, with a median age of 6.5 years old). The most common ABR abnormalities observed were absent waves I and III (%70 absent I waves, %43.75 absent III waves). Twelve of sixteen patients (%75) had an ABR abnormality in at least one ear, of these, four patients had normal hearing and three of them had periferal hearing loss. 12 (75%) patients had complaint of postural imbalance. 11(69%) of patients had peripheral and one (6%) patient had central impairment. Nine of sixteen patients (56.25%) show some degree of dysphagia (either penetration or aspiration). Two patients (12.5%) showed aspiration both liquid and viscous nutrition. Three patients (18.75%) showed aspiration primarily in liquids and two of them had penetration with viscous nutrition. Three patients (18.75%) had penetration with no aspiration neither liquid nor viscous nutrition (PEN-ASP score was 3, 3, 5, respectively). Conclusion: There is no curative treatment for this devastating and fatal disorder and hearing impairment, balance and swallowing disorders can be seen especially late onset form of disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ijporl.2015.11.009" target="_blank" rel="noreferrer noopener">10.1016/j.ijporl.2015.11.009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Adolescent
Aksoy S
Akyol U
Article
aspiration scale
auditory response
Balance disorders
body equilibrium
characteristics
Child
Clinical Article
Controlled Study
Demir N
Dysphagia
Endoscopy
feeding difficulties
Female
Flexible endoscopy
hearing
hearing impairment
Hearing problems
Human
International Journal of Pediatric Otorhinolaryngology
Kuscu O
Male
Niemann Pick disease/di [Diagnosis]
Niemann-Pick Disease
NPC
Otorhinolaryngology
penetration
postural imbalance
Preschool Child
Priority Journal
Prospective Study
pure tone audiometry
School Child
Senirli R T
stabilography
Swallowing
Swallowing disorders
tone and motor problems
Topcu M
Trajectory
vestibular system
Yigit O
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1055/s-0034-1391308" target="_blank" rel="noreferrer noopener">http://doi.org/10.1055/s-0034-1391308</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A two-step multidisciplinary approach to treat recurrent esophageal strictures in children with epidermolysis bullosa dystrophica
Publisher
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Endoscopy
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
Subject
The topic of the resource
Male; Treatment Outcome; Follow-Up Studies; Child; Humans; Adolescent; Female; Child Preschool; Infant; Recurrence; Combined Modality Therapy; Gastrostomy; Dilatation/methods; Epidermolysis Bullosa Dystrophica/complications; Esophageal Stenosis/etiology/therapy; feeding difficulties; Epidermolysis Bullosa; surgical intervention; orthograde balloon dilation; retrograde dilation; growth improvement; nutrition
Creator
An entity primarily responsible for making the resource
Vowinkel T; Laukoetter M; Mennigen R; Hahnenkamp K; Gottschalk A; Boschin M; Frosch M; Senninger N; Tubergen D
Description
An account of the resource
In children with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), esophageal scarring leads to esophageal strictures with dysphagia, followed by malnutrition and delayed development. We describe a two-step multidisciplinary therapeutic approach to overcome malnutrition and growth retardation. In Step 1, under general anesthesia, orthograde balloon dilation of the esophagus is followed by gastrostomy creation using a direct puncture technique. In Step 2, further esophageal strictures are treated by retrograde dilation via the established gastrostomy; this step requires only a short sedation period. A total of 12 patients (median age 7.8 years, range 6 weeks to 17 years) underwent successful orthograde balloon dilation of esophageal strictures combined with direct puncture gastrostomy. After 12 and 24 months in 11 children, a substantial improvement of growth and nutrition was achieved (body mass index [BMI] standard deviation score [SDS] + 0.59 and + 0.61, respectively). In one child, gastrostomy was removed because of skin ulcerations after 10 days. Recurrent esophageal strictures were treated successfully in five children. The combined approach of balloon dilation and gastrostomy is technically safe in children with RDEB, and helps to promote catch-up growth and body weight. In addition, recurrent esophageal strictures can be treated successfully without general anesthesia in a retrograde manner via the established gastrostomy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1055/s-0034-1391308" target="_blank" rel="noreferrer noopener">10.1055/s-0034-1391308</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Adolescent
Boschin M
Child
Child Preschool
Combined Modality Therapy
Dilatation/methods
Endoscopy
epidermolysis bullosa
Epidermolysis Bullosa Dystrophica/complications
Esophageal Stenosis/etiology/therapy
feeding difficulties
Female
Follow-up Studies
Frosch M
Gastrostomy
Gottschalk A
growth improvement
Hahnenkamp K
Humans
Infant
Laukoetter M
Male
Mennigen R
Nutrition
orthograde balloon dilation
Recurrence
retrograde dilation
Senninger N
surgical intervention
Treatment Outcome
Tubergen D
Vowinkel T