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Text
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URL Address
<a href="http://doi.org/10.1097/00000542-200301000-00030" target="_blank" rel="noreferrer">http://doi.org/10.1097/00000542-200301000-00030</a>
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Title
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Modulation of peripheral endogenous opioid analgesia by central afferent blockade
Publisher
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Anesthesiology
Date
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2003
Subject
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Male; Analgesics; Animals; Rats; Injections; Immunohistochemistry; Spinal; Enkephalin; beta-Endorphin/metabolism; Wistar; Pain Threshold/drug effects; Neurons; Afferent/drug effects; Central Nervous System/drug effects; Endorphins/metabolism/physiology; Flow Cytometry; Foot/pathology; Inflammation/pathology; Methionine/metabolism; Morphine/administration & dosage/pharmacology; Opioid/administration & dosage/pharmacology; Peripheral Nerves/drug effects; Psychomotor Performance/drug effects
Creator
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Schmitt TK; Mousa SA; Brack A; Schmidt DK; Rittner HL; Welte M; Schafer M; Stein C
Description
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BACKGROUND: Peripheral tissue injury causes a migration of opioid peptide-containing immune cells to the inflamed site. The subsequent release and action of these peptides on opioid receptors localized on peripheral sensory nerve terminals causes endogenous analgesia. The spinal application of opioid drugs blocks the transmission of nociceptive information from peripheral injury. This study investigates the influence of exogenous spinal opioid analgesia on peripheral endogenous opioid analgesia. METHODS: Six and forty-eight hours after initiation of continuous intrathecal morphine infusion and administration of Freund's complete adjuvant into the hind paw of rats, antinociceptive and antiinflammatory effects were measured by paw pressure threshold, paw volume, and paw temperature, respectively. Inflammation and quantity of opioid-containing cells were evaluated by immunocytochemistry and flow cytometry. Cold water swim stress-induced endogenous analgesia was examined 24 h after discontinuation of intrathecal morphine administration. RESULTS: Intrathecal morphine (10 micro g/h) resulted in a significant and stable increase of paw pressure threshold ( P 0.05). At 48 but not at 6 h after Freund's complete adjuvant, the number of beta-endorphin-containing cells and cold water swim-induced antinociception were significantly reduced in intrathecal morphine-treated rats compared with those treated with intrathecal vehicle ( P< 0.05). CONCLUSIONS: These findings suggest an interplay of central and peripheral mechanisms of pain control. An effective central inhibition of pain apparently signals a reduced need for recruitment of opioid-containing immune cells to injured sites.
2003
Identifier
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<a href="http://doi.org/10.1097/00000542-200301000-00030" target="_blank" rel="noreferrer">10.1097/00000542-200301000-00030</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2003
Afferent/drug effects
Analgesics
Anesthesiology
Animals
Backlog
beta-Endorphin/metabolism
Brack A
Central Nervous System/drug effects
Endorphins/metabolism/physiology
Enkephalin
Flow Cytometry
Foot/pathology
Immunohistochemistry
Inflammation/pathology
Injections
Journal Article
Male
Methionine/metabolism
Morphine/administration & dosage/pharmacology
Mousa SA
Neurons
Opioid/administration & dosage/pharmacology
Pain Threshold/drug effects
Peripheral Nerves/drug effects
Psychomotor Performance/drug effects
Rats
Rittner HL
Schafer M
Schmidt DK
Schmitt TK
Spinal
Stein C
Welte M
Wistar