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              <text>&lt;a href="http://doi.org/10.1159/000006815" target="_blank" rel="noreferrer"&gt;http://doi.org/10.1159/000006815&lt;/a&gt;</text>
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                <text>Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction</text>
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                <text>Female; Humans; Male; Middle Aged; Biomarkers of Pain; Biomarkers Reference List; Leukocytes; beta-Endorphin/blood/immunology; Myocardial Infarction/blood; C-Reactive Protein/analysis; Mononuclear/metabolism</text>
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                <text>Buratti T; Schratzberger P; Dunzendorfer S; Manfreda SE; Pechlaner C; Joannidis M; Sacerdote P; Panerai AE; Wiedermann CJ</text>
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                <text>Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p &lt; 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.</text>
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                <text>1998</text>
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                <text>&lt;a href="http://doi.org/10.1159/000006815" target="_blank" rel="noreferrer"&gt;10.1159/000006815&lt;/a&gt;</text>
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