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Text
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URL Address
<a href="http://doi.org/10.1159/000006815" target="_blank" rel="noreferrer">http://doi.org/10.1159/000006815</a>
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Title
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Decreased levels of beta-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction
Publisher
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Cardiology
Date
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1998
Subject
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Female; Humans; Male; Middle Aged; Biomarkers of Pain; Biomarkers Reference List; Leukocytes; beta-Endorphin/blood/immunology; Myocardial Infarction/blood; C-Reactive Protein/analysis; Mononuclear/metabolism
Creator
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Buratti T; Schratzberger P; Dunzendorfer S; Manfreda SE; Pechlaner C; Joannidis M; Sacerdote P; Panerai AE; Wiedermann CJ
Description
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Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive beta-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of beta-endorphin in mononuclear leukocytes of 30.2 +/- 6.9 pg/10(6) cells on admission were in the normal range of 20-40 pg/10(6) cells and decreased significantly to 6.9 +/- 1.9 pg/10(6) cells after 48 h (p < 0.05). Decreased levels of mononuclear leukocyte-associated beta-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
1998
Identifier
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<a href="http://doi.org/10.1159/000006815" target="_blank" rel="noreferrer">10.1159/000006815</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1998
Backlog
beta-Endorphin/blood/immunology
Biomarkers of Pain
Biomarkers Reference List
Buratti T
C-Reactive Protein/analysis
Cardiology
Dunzendorfer S
Female
Humans
Joannidis M
Journal Article
Leukocytes
Male
Manfreda SE
Middle Aged
Mononuclear/metabolism
Myocardial Infarction/blood
Panerai AE
Pechlaner C
Sacerdote P
Schratzberger P
Wiedermann CJ