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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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Backlog
URL Address
<a href="http://doi.org/10.1046/j.1460-9592.2001.00697.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1460-9592.2001.00697.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Unlicensed and off label analgesic use in paediatric pain management
Publisher
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Paediatric Anaesthesia
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
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Child; Humans; Great Britain; Drug Utilization; Prospective Studies; Hospitals; Pediatric; Pain/drug therapy; Analgesics/therapeutic use; Drug Approval
Creator
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Conroy S; Peden V
Description
An account of the resource
BACKGROUND: The management of pain in children has advanced enormously in recent years. Pharmacological treatment of pain is complicated however, by the widespread use of unlicensed and off label medicines in the paediatric population, leading to everyday practical problems. This study aimed to document the incidence and nature of unlicensed and off label analgesic agents in children. METHODS: Data regarding analgesic use were collected prospectively over a 4-week period from two wards. The data were analysed to determine whether the drug use was licensed, unlicensed or off label. RESULTS: Seven hundred and fifteen prescription episodes were analysed. Some 480 of these (67%) were licensed; 235 were licensed medicines used in an off label manner (33%). No medicines were unlicensed. Paracetamol was the most common analgesic used. CONCLUSION: Issues regarding the use of off label drugs in children at risk of pain are discussed. Suggestions are made regarding the way forward for the future.
2001
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1460-9592.2001.00697.x" target="_blank" rel="noreferrer">10.1046/j.1460-9592.2001.00697.x</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2001
Analgesics/therapeutic use
Backlog
Child
Conroy S
Drug Approval
Drug Utilization
Great Britain
Hospitals
Humans
Journal Article
Paediatric Anaesthesia
Pain/drug Therapy
Peden V
Pediatric
Prospective Studies
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
December 2017 List
URL Address
<a href="http://doi.org/10.1007/s00134-005-2863-2" target="_blank" rel="noreferrer">http://doi.org/10.1007/s00134-005-2863-2</a>
Notes
<p>Provoost, Veerle<br />Cools, Filip<br />Bilsen, Johan<br />Ramet, Jose<br />Deconinck, Peter<br />Vander Stichele, Robert<br />Vande Velde, Anne<br />Van Herreweghe, Inge<br />Mortier, Freddy<br />Vandenplas, Yvan<br />Deliens, Luc<br />Comment in: Intensive Care Med. 2006 Jan;32(1):6-8; PMID: 16311743</p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The use of drugs with a life-shortening effect in end-of-life care in neonates and infants
Publisher
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Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
Subject
The topic of the resource
Analgesics Opioid; Euthanasia; Muscle Relaxants Central; Potassium Chloride; Practice Patterns Physicians'; Terminal Care; 0 (analgesics Opioid); 0 (muscle Relaxants Central); 660yq98i10 (potassium Chloride); Belgium; Decision Making; Drug Utilization; Humans; Infant; Infant Newborn; Intention; Pain/dt [drug Therapy]; Terminal Care/es [ethics]
Creator
An entity primarily responsible for making the resource
Provoost V; Cools F; Bilsen J; Ramet J; Deconinck P; Vander Stichele R; Vande Velde A; Van Herreweghe I; Mortier F; Vandenplas Y; Deliens L
Description
An account of the resource
OBJECTIVE: The purpose was to describe the use of drugs with a possible or certain life-shortening effect in end-of-life care in infants and to evaluate the possibly lethal effect. DESIGN: For 292/298 deaths of live born infants (<1 year), in a 1-year period (between 1 August 1999 and 31 July 2000) in Flanders, Belgium, the attending physician could be identified and was sent an anonymous questionnaire. The questionnaires relating to deaths directly preceded by the administration of drugs were reviewed by a multi-disciplinary panel. RESULTS: The response rate was 86.6% (253/292). In 57 cases (22.5%), drugs were administered directly before death. In 17/57 cases, the physician explicitly intended to hasten death. In 16/17 cases information about the drug(s) was available: opioids were administered in 14, a muscle relaxant in 5 and potassium chloride in 3 cases. In 13 cases where the lethal effect could be evaluated, the panel judged that the drugs were effective in hastening death in 10 cases. In most cases the estimated life-shortening was <24 h. In 40/57 cases the physician administered drugs to alleviate pain and/or symptoms, taking into account a possible life-shortening effect without explicitly intending it. Opioids were administered in all 30 cases where information about the drug(s) was supplied. In 13 cases the lethal effect could be evaluated, and in 6 cases the panel judged that the drugs had hastened death. CONCLUSIONS: When life-shortening was explicitly intended, (dosages of) drugs were likely to be lethal. Drugs administered also clearly hastened death in some cases where life-shortening was not explicitly intended.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00134-005-2863-2" target="_blank" rel="noreferrer">10.1007/s00134-005-2863-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
0 (analgesics Opioid)
0 (muscle Relaxants Central)
2006
660yq98i10 (potassium Chloride)
Analgesics Opioid
Belgium
Bilsen J
Cools F
December 2017 List
Decision Making
Deconinck P
Deliens L
Drug Utilization
Euthanasia
Humans
Infant
Infant Newborn
Intensive Care Medicine
Intention
Mortier F
Muscle Relaxants Central
Pain/dt [drug Therapy]
Potassium Chloride
Practice Patterns Physicians'
Provoost V
Ramet J
Terminal Care
Terminal Care/es [ethics]
Van Herreweghe I
Vande Velde A
Vandenplas Y
Vander Stichele R