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Dublin Core
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Title
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August 2022 List
Text
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Citation List Month
August 2022 List
URL Address
<a href="http://doi.org/10.1016/j.jpainsymman.2022.05.020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jpainsymman.2022.05.020</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Polypharmacy in children and young people with life-limiting conditions from 2000-2015: a repeated cross-sectional study in England
Publisher
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Journal of pain and symptom management
Date
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2022
Subject
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child; pediatrics; England; chronic disease; female; male; adult; human; young adult; age; article; controlled study; major clinical study; nervous system; cross-sectional study; cohort analysis; observational study; prevalence; polypharmacy; congenital disorder
Creator
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Fraser LK; Gibson-Smith D; Jarvis S; Papworth A; Neefjes V; Hills M; Doran T; Taylor J
Description
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CONTEXT: Polypharmacy is often appropriate for children with life-limiting conditions but is associated with an increase in hospitalisations and inappropriate prescribing, and can affect the quality of life of children and their families as they manage complex medication schedules. Despite this, little is known about polypharmacy in this population. OBJECTIVE(S): To describe the prevalence and patterns of polypharmacy in children with a life-limiting condition in a nationally representative cohort in England. METHOD(S): Observational study of children (age 0-19 years) with a life-limiting condition in a national database from 2000 to 2015. Common definitions of polypharmacy were used to determine polypharmacy prevalence in each year based on unique medications and regular medications. Hierarchical regression analyses were used to explore factors associated with polypharmacy. RESULT(S): Data on 15,829 individuals were included. Each year 27-39% of children were prescribed >=5 unique medications and 8-12% were prescribed >=10.Children with a respiratory (OR 7.6, 95%CI 6.4-9.0), neurological (OR 2.8, 95%CI 2.4-3.2) or metabolic (OR 2.2, 95%CI 1.7-2.8) condition were more likely than those with a congenital condition to experience polypharmacy. Increasing age, being diagnosed with a LLC under 1 year of age, having >1 life-limiting or chronic condition or living in areas of higher deprivation were also associated with higher prevalence of polypharmacy. CONCLUSION(S): Children with life-limiting conditions have a high prevalence of polypharmacy and some children are at greater risk than others. More research is needed to understand and address the factors that lead to problematic polypharmacy in this population. Copyright © 2022. Published by Elsevier Inc.
Identifier
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<a href="http://doi.org/10.1016/j.jpainsymman.2022.05.020" target="_blank" rel="noreferrer noopener">10.1016/j.jpainsymman.2022.05.020</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2022
Adult
Age
Article
August 2022 List
Child
Chronic Disease
Cohort Analysis
congenital disorder
Controlled Study
Cross-sectional Study
Doran T
England
Female
Fraser LK
Gibson-Smith D
Hills M
Human
Jarvis S
Journal of Pain and Symptom Management
Major Clinical Study
Male
Neefjes V
Nervous System
Observational Study
Papworth A
Pediatrics
Polypharmacy
Prevalence
Taylor J
Young Adult