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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1080/08880010500198285" target="_blank" rel="noreferrer">http://doi.org/10.1080/08880010500198285</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Osteoporosis at presentation of childhood ALL: management with pamidronate
Publisher
An entity responsible for making the resource available
Pediatric Hematology And Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Child; Female; Humans; Male; Leukemia; Preschool; Clodronate; Acute; Lymphocytic; Bone Density/drug effects; Diphosphonates/administration & dosage; Fractures; Bone Density Conservation Agents/administration & dosage; L1/complications/radiography/therapy; Osteoporosis/drug therapy/etiology/radiography; Spinal Fractures/drug therapy/etiology/radiography; Spontaneous/drug therapy/etiology/radiography
Creator
An entity primarily responsible for making the resource
Goldbloom EB; Cummings EA; Yhap M
Description
An account of the resource
Vertebral fractures at diagnosis of childhood acute lymphoblastic leukemia (ALL) are an uncommon but recognized problem. Clinical issues associated with pathological fractures in these children include pain control and the potential for further treatment-associated fractures and long-term bony morbidity. The authors report the successful use of pamidronate in two children who presented with vertebral compression fractures at diagnosis of ALL. Both patients had pain and low bone mineral density at baseline. In addition to standard chemotherapy, pamidronate (1 mg/kg, IV) was given bimonthly. Initial rapid symptom relief and gradual improvement of bone mineral density was demonstrated in both patients.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/08880010500198285" target="_blank" rel="noreferrer">10.1080/08880010500198285</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Acute
Backlog
Bone Density Conservation Agents/administration & dosage
Bone Density/drug effects
Child
Clodronate
Cummings EA
Diphosphonates/administration & dosage
Female
Fractures
Goldbloom EB
Humans
Journal Article
L1/complications/radiography/therapy
Leukemia
Lymphocytic
Male
Osteoporosis/drug therapy/etiology/radiography
Pediatric Hematology And Oncology
Preschool
Spinal Fractures/drug therapy/etiology/radiography
Spontaneous/drug therapy/etiology/radiography
Yhap M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0885-3924(03)00225-2" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0885-3924(03)00225-2</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The use of subcutaneous pamidronate
Publisher
An entity responsible for making the resource available
Journal Of Pain And Symptom Management
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
Subject
The topic of the resource
Humans; Injections; Subcutaneous; Clodronate; Hypercalcemia/drug therapy; Anti-Inflammatory Agents/administration & dosage; Diphosphonates/administration & dosage
Creator
An entity primarily responsible for making the resource
Duncan AR
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0885-3924(03)00225-2" target="_blank" rel="noreferrer">10.1016/s0885-3924(03)00225-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2003
2003
Anti-Inflammatory Agents/administration & dosage
Backlog
Clodronate
Diphosphonates/administration & dosage
Duncan AR
Humans
Hypercalcemia/drug therapy
Injections
Journal Article
Journal of Pain and Symptom Management
Subcutaneous
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1056/nejm199810013391402" target="_blank" rel="noreferrer">http://doi.org/10.1056/nejm199810013391402</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cyclic administration of pamidronate in children with severe osteogenesis imperfecta
Publisher
An entity responsible for making the resource available
The New England Journal Of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
Subject
The topic of the resource
Child; Female; Humans; Male; Drug Administration Schedule; adolescent; Preschool; Non-U.S. Gov't; Research Support; Pain/drug therapy; Clodronate; Bone Density/drug effects; Periodicity; Diphosphonates/administration & dosage; Alkaline Phosphatase/blood; Bone Development/drug effects; Bone Resorption/drug therapy; Bone/prevention & control; Calcium/urine; Fractures; Lumbar Vertebrae/physiopathology/radiography; Osteogenesis Imperfecta/drug therapy/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Glorieux FH; Bishop NJ; Plotkin H; Chabot G; Lanoue G; Travers R
Description
An account of the resource
BACKGROUND: Severe osteogenesis imperfecta is a disorder characterized by osteopenia, frequent fractures, progressive deformity, loss of mobility, and chronic bone pain. There is no effective therapy for the disorder. We assessed the effects of treatment with a bisphosphonate on bone resorption. METHODS: In an uncontrolled observational study involving 30 children who were 3 to 16 years old and had severe osteogenesis imperfecta, we administered pamidronate intravenously (mean [+/-SD] dose, 6.8+/-1.1 mg per kilogram of body weight per year) at 4-to-6-month intervals for 1.3 to 5.0 years. Clinical status, biochemical characteristics reflecting bone turnover, the bone mineral density of the lumbar spine, and radiologic changes were assessed regularly during treatment. RESULTS: Administration of pamidronate resulted in sustained reductions in serum alkaline phosphatase concentrations and in the urinary excretion of calcium and type I collagen N-telopeptide. There was a mean annualized increase of 41.9+/-29.0 percent in bone mineral density, and the deviation of bone mineral density from normal, as indicated by the z score, improved from -5.3+/-1.2 to -3.4+/-1.5. The cortical width of the metacarpals increased by 27+/-20.2 percent per year. The increases in the size of the vertebral bodies suggested that new bone had formed. The mean incidence of radiologically confirmed fractures decreased by 1.7 per year (P<0.001). Treatment with pamidronate did not alter the rate of fracture healing, the growth rate, or the appearance of the growth plates. Mobility and ambulation improved in 16 children and remained unchanged in the other 14. All the children reported substantial relief of chronic pain and fatigue. CONCLUSIONS: In children with severe osteogenesis imperfecta, cyclic administration of intravenous pamidronate improved clinical outcomes, reduced bone resorption, and increased bone density.
1998
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1056/nejm199810013391402" target="_blank" rel="noreferrer">10.1056/nejm199810013391402</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1998
Adolescent
Alkaline Phosphatase/blood
Backlog
Bishop NJ
Bone Density/drug effects
Bone Development/drug effects
Bone Resorption/drug therapy
Bone/prevention & control
Calcium/urine
Chabot G
Child
Clodronate
Diphosphonates/administration & dosage
Drug Administration Schedule
Female
Fractures
Glorieux FH
Humans
Journal Article
Lanoue G
Lumbar Vertebrae/physiopathology/radiography
Male
Non-U.S. Gov't
Osteogenesis Imperfecta/drug therapy/metabolism/physiopathology
Pain/drug Therapy
Periodicity
Plotkin H
Preschool
Research Support
The New England Journal Of Medicine
Travers R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1067/mpd.2000.107838" target="_blank" rel="noreferrer">http://doi.org/10.1067/mpd.2000.107838</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Osteoporosis pseudoglioma syndrome: treatment of spinal osteoporosis with intravenous bisphosphonates
Publisher
An entity responsible for making the resource available
The Journal Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Child; Female; Humans; Male; Analgesics; Growth; Non-U.S. Gov't; Research Support; Syndrome; Infusions; Intravenous; Clodronate; Pain/prevention & control; Clodronic Acid/administration & dosage; Non-Narcotic/administration & dosage; Diphosphonates/administration & dosage; Fractures; Bone Density/physiology; Bone/complications/physiopathology; Osteoporosis/complications/drug therapy/physiopathology; Spine/physiopathology; Vision Disorders/complications
Creator
An entity primarily responsible for making the resource
Zacharin M; Cundy T
Description
An account of the resource
OBJECTIVES: To determine whether intravenous bisphosphonate treatment is helpful for children with osteoporosis pseudoglioma syndrome who have severe osteoporosis. METHODS: Three children (ages 9 to 11 years) with osteoporosis pseudoglioma syndrome who had multiple vertebral collapse were treated over a 2-year period with intermittent intravenous bisphosphonate infusions (pamidronate in 2, clodronate in 1). The responses to therapy were assessed with clinical and radiographic evaluation and bone densitometry of the spine. RESULTS: All 3 subjects reported early reductions in bone pain and improved mobility. Radiographs showed dense new bone in the vertebral end plates and remodeling of the vertebral bodies. Areal bone mineral density at the lumbar spine (age-appropriate SD score) improved from a mean of -4.5 before treatment to -2.8 after 2 years (P <.05). No new fractures occurred, and side effects were minimal. Growth and pubertal development proceeded normally. CONCLUSIONS: Intravenous bisphosphonate therapy appears safe and beneficial in patients with this condition and may prevent progressive vertebral deformity.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1067/mpd.2000.107838" target="_blank" rel="noreferrer">10.1067/mpd.2000.107838</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Analgesics
Backlog
Bone Density/physiology
Bone/complications/physiopathology
Child
Clodronate
Clodronic Acid/administration & dosage
Cundy T
Diphosphonates/administration & dosage
Female
Fractures
Growth
Humans
Infusions
Intravenous
Journal Article
Male
Non-Narcotic/administration & dosage
Non-U.S. Gov't
Osteoporosis/complications/drug therapy/physiopathology
Pain/prevention & control
Research Support
Spine/physiopathology
Syndrome
The Journal Of Pediatrics
Vision Disorders/complications
Zacharin M