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Text
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<a href="http://doi.org/10.1016/j.tips.2005.01.009" target="_blank" rel="noreferrer">http://doi.org/10.1016/j.tips.2005.01.009</a>
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Title
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Individual responder analyses for pain: does one pain scale fit all?
Publisher
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Trends In Pharmacological Sciences
Date
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2005
Subject
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Humans; Reproducibility of Results; P.H.S.; Research Support; U.S. Gov't; Comparative Study; Pain/drug therapy/physiopathology; Clinical Trials/methods/trends; Pain Measurement/drug effects/methods/standards
Creator
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Dionne RA; Bartoshuk L; Mogil J; Witter J
Description
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The outcomes of clinical trials are based on the mean responses of large numbers of subjects but fail to address inter-individual differences. The molecular mechanisms that underlie pain vary among individuals over time and among different types of pain to produce wide inter-individual variations in pain perception and response. Gender, ethnicity, temperament and genetic factors also contribute to individual variation in pain sensitivity and responses to analgesics. Pain measurement scales can be used differently across individuals based on the past pain experiences of individuals. We propose that individual responder analyses could be used in clinical trials to better detect analgesic activity across patient groups and within sub-groups, and to identify molecular-genetic mechanisms that contribute to individual variation.
2005
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<a href="http://doi.org/10.1016/j.tips.2005.01.009" target="_blank" rel="noreferrer">10.1016/j.tips.2005.01.009</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2005
Backlog
Bartoshuk L
Clinical Trials/methods/trends
Comparative Study
Dionne RA
Humans
Journal Article
Mogil J
P.H.S.
Pain Measurement/drug effects/methods/standards
Pain/drug therapy/physiopathology
Reproducibility of Results
Research Support
Trends In Pharmacological Sciences
U.S. Gov't
Witter J