1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1542/pir.28-3-101" target="_blank" rel="noreferrer">http://doi.org/10.1542/pir.28-3-101</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gastroesophageal reflux
Publisher
An entity responsible for making the resource available
Pediatrics In Review / American Academy Of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
Subject
The topic of the resource
Child; Humans; Prognosis; adolescent; Preschool; infant; Nervous System Diseases/complications; Nutritional Failure; Diagnosis; Differential; Digestive System; Pediatrics/methods; Proton Pumps/antagonists & inhibitors; Enzyme Inhibitors/therapeutic use; Diagnostic Techniques; Gastroesophageal Reflux/complications/diagnosis/physiopathology/therapy; Histamine H2 Antagonists/therapeutic use; Medical History Taking/methods; Respiratory Tract Diseases/etiology/prevention & control; Vomiting/diagnosis/etiology
Creator
An entity primarily responsible for making the resource
Michail S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/pir.28-3-101" target="_blank" rel="noreferrer">10.1542/pir.28-3-101</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
2007
2007
Adolescent
Backlog
Child
Diagnosis
Diagnostic Techniques
Differential
Digestive System
Enzyme Inhibitors/therapeutic use
Gastroesophageal Reflux/complications/diagnosis/physiopathology/therapy
Histamine H2 Antagonists/therapeutic use
Humans
Infant
Journal Article
Medical History Taking/methods
Michail S
Nervous System Diseases/complications
Nutritional Failure
Pediatrics In Review / American Academy Of Pediatrics
Pediatrics/methods
Preschool
Prognosis
Proton Pumps/antagonists & inhibitors
Respiratory Tract Diseases/etiology/prevention & control
Vomiting/diagnosis/etiology
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/0928-4257(93)90034-q" target="_blank" rel="noreferrer">http://doi.org/10.1016/0928-4257(93)90034-q</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Brain and gut neuropeptides in peripheral blood mononuclear cells
Publisher
An entity responsible for making the resource available
Journal Of Physiology, Paris
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
Humans; Male; Adult; Aged; Middle Aged; Brain; Animals; Rats; 80 and over; Sprague-Dawley; Aging/metabolism; beta-Endorphin/blood/pharmacology; Chemotaxis/drug effects; Cholecystokinin/blood/pharmacology; Digestive System; Headache/blood; Lymphocytes/metabolism; Neuropeptides/blood; Schizophrenia/blood; Vasoactive Intestinal Peptide/blood/pharmacology
Creator
An entity primarily responsible for making the resource
Panerai AE; Sacerdote P
Description
An account of the resource
Neuropeptides, initially thought to be common features of gut and brain, are only synthesized in immune cells and modulate immune functions. The presence and possible functions of these peptides in immune cells in both physiological or pathological conditions have been investigated in our laboratory in the last years. Some of the data obtained are reviewed here, and future developments of the field are indicated.
1993
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0928-4257(93)90034-q" target="_blank" rel="noreferrer">10.1016/0928-4257(93)90034-q</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
80 And Over
Adult
Aged
Aging/metabolism
Animals
Backlog
beta-Endorphin/blood/pharmacology
Brain
Chemotaxis/drug effects
Cholecystokinin/blood/pharmacology
Digestive System
Headache/blood
Humans
Journal Article
Journal Of Physiology, Paris
Lymphocytes/metabolism
Male
Middle Aged
Neuropeptides/blood
Panerai AE
Rats
Sacerdote P
Schizophrenia/blood
Sprague-Dawley
Vasoactive Intestinal Peptide/blood/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1016/s0304-3959(99)00267-5" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0304-3959(99)00267-5</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Humans; Cohort Studies; Death; Disease Progression; Risk Assessment; Non-U.S. Gov't; Research Support; Models; Statistical; Anti-Inflammatory Agents; Databases; Factual; Digestive System; Endoscopy; Gastrointestinal Hemorrhage/chemically induced/mortality; Non-Steroidal/adverse effects; Peptic Ulcer Perforation/chemically induced/mortality
Creator
An entity primarily responsible for making the resource
Tramer MR; Moore RA; Reynolds DJ; McQuay HJ
Description
An account of the resource
Randomised controlled trials (RCTs) alone are unlikely to provide reliable estimates of the incidence of rare events because of their limited size. Cohort, case control, and other observational studies have large numbers but are vulnerable to various kinds of bias. Wanting to estimate the risk of death from bleeding or perforated gastroduodenal ulcers with chronic usage of non-steroidal anti-inflammatory drugs (NSAIDs) with greater precision, we developed a model to quantify the frequency of rare adverse events which follow a biological progression. The model combined data from both RCTs and observational studies. We searched systematically for any report of chronic (>/=2 months) use of NSAIDs which gave information on gastroduodenal ulcer, bleed or perforation, death due to these complications, or progression from one level of harm to the next. Fifteen RCTs (19364 patients exposed to NSAIDs for 2-60 months), three cohort studies (215076 patients redeeming a NSAID prescription over a 3-12 month period), six case-control studies (2957 cases) and 20 case series (7406), and case reports (4447) were analysed. In RCTs the incidence of bleeding or perforation in 6822 patients exposed to NSAIDs was 0.69%; two deaths occurred. Of 11040 patients with bleeding or perforation with or without NSAID exposure across all reports, 6-16% (average 12%) died; the risk was lowest in RCTs and highest in case reports. Death from bleeding or perforation in all controls not exposed to NSAIDs occurred in 18 out of 849489 (0.002%). From these numbers we calculated the number-needed-to-treat for one patient to die due to gastroduodenal complications with chronic (>/=2 months) NSAIDs as 1/((0.69x inverted question mark6-16%, average 12% inverted question mark)-0.002%))=909-2500 (average 1220). On average 1 in 1200 patients taking NSAIDs for at least 2 months will die from gastroduodenal complications who would not have died had they not taken NSAIDs. This extrapolates to about 2000 deaths each year in the UK.
2000
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3959(99)00267-5" target="_blank" rel="noreferrer">10.1016/s0304-3959(99)00267-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2000
Anti-Inflammatory Agents
Backlog
Cohort Studies
Databases
Death
Digestive System
Disease Progression
Endoscopy
Factual
Gastrointestinal Hemorrhage/chemically induced/mortality
Humans
Journal Article
McQuay HJ
Models
Moore RA
Non-Steroidal/adverse effects
Non-U.S. Gov't
Pain
Peptic Ulcer Perforation/chemically induced/mortality
Research Support
Reynolds DJ
Risk Assessment
statistical
Tramer MR