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Text
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URL Address
<a href="http://doi.org/10.1097/00006454-200012000-00002" target="_blank" rel="noreferrer">http://doi.org/10.1097/00006454-200012000-00002</a>
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Title
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Serious adverse events after measles-mumps-rubella vaccination during a fourteen-year prospective follow-up
Publisher
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The Pediatric Infectious Disease Journal
Date
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2000
Subject
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Child; Female; Humans; Male; Adult; Follow-Up Studies; Prospective Studies; Finland; adolescent; Preschool; Non-U.S. Gov't; Research Support; infant; Nervous System Diseases/etiology; Adverse Drug Reaction Reporting Systems; Drug Hypersensitivity/etiology; Measles-Mumps-Rubella Vaccine/adverse effects; Vaccination
Creator
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Patja A; Davidkin I; Kurki T; Kallio MJ; Valle M; Peltola H
Description
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BACKGROUND: Several disorders have been attributed to measles-mumps-rubella (MMR) vaccination during the past decade. The aim of this prospective follow-up study was to identify serious adverse events causally related to MMR vaccination. METHODS: When the MMR vaccination program was launched in Finland in 1982, a countrywide surveillance system was set up to detect serious adverse events associated with MMR. To obtain detailed case histories vaccinees' clinical charts were reviewed. Serum samples were analyzed to trace concurrent infections. SETTING: All hospitals and health centers in Finland from 1982 through 1996. RESULTS: Immunization of 1.8 million individuals and consumption of almost 3 million vaccine doses by the end of 1996 gave rise to 173 potentially serious reactions claimed to have been caused by MMR vaccination. In all, 77 neurologic, 73 allergic and 22 miscellaneous reactions and 1 death were reported, febrile seizure being the most common event. However, 45% of these events proved to be probably caused or contributed by some other factor, giving an incidence of serious adverse events with possible or indeterminate causal relation with MMR vaccination of 5.3 per 100,000 vaccinees or 3.2 per 100,000 vaccine doses. CONCLUSIONS: Causality between immunization and a subsequent untoward event cannot be estimated solely on the basis of a temporal relation. Comprehensive analysis of the reported adverse reactions established that serious events causally related to MMR vaccine are rare and greatly outweighed by the risks of natural MMR diseases.
2000
Identifier
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<a href="http://doi.org/10.1097/00006454-200012000-00002" target="_blank" rel="noreferrer">10.1097/00006454-200012000-00002</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2000
Adolescent
Adult
Adverse Drug Reaction Reporting Systems
Backlog
Child
Davidkin I
Drug Hypersensitivity/etiology
Female
Finland
Follow-up Studies
Humans
Infant
Journal Article
Kallio MJ
Kurki T
Male
Measles-Mumps-Rubella Vaccine/adverse effects
Nervous System Diseases/etiology
Non-U.S. Gov't
Patja A
Peltola H
Preschool
Prospective Studies
Research Support
The Pediatric Infectious Disease Journal
Vaccination
Valle M