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Text
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<a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=466928" target="_blank" rel="noreferrer">http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=466928</a>
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Title
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Morphine kinetics in children
Publisher
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Clinical Pharmacology & Therapeutics
Date
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1979
Subject
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Child; Female; Male; Pain; Analgesia; Preschool; infant; Anesthesia; Human; Adolescence; Operative; Surgical Procedures; Kinetics; Morphine/administration & dosage/blood/metabolism; Preanesthetic Medication
Creator
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Dahlstrom B; Bolme P; Feychting H; Noack G; Paalzow L
Description
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The kinetics of morphine in the plasma of children (0 to 15 yr) can in most cases be adequately described by a triexponential function. When the dosage in children receiving morphine as premedication before surgery is based on kilograms of body weight, there are only minor differences in the kinetic patterns of morphine at different ages (0 to 1, 1 to 7, and 7 to 15 yr). No significant difference in the morphine kinetics was observed between patients (7 to 15 yr) receiving the drug only as premedication and those who also received doses during surgery. The minimum morphine concentration in plasma necessary to suppress the clinical signs of pain during surgery was found to be 65 ng/ml (95% confidence limits of 46 to 83 ng/ml). Based on these minimum effective plasma levels of morphine, there does not seem to be any difference between children of different ages in their sensitivity to morphine. No difference was found in the minimum effective level of morphine when clinical signs of pain were observed by different anesthesiologists.
1979
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1979
Adolescence
Analgesia
Anesthesia
Backlog
Bolme P
Child
Clinical Pharmacology & Therapeutics
Dahlstrom B
Female
Feychting H
Human
Infant
Journal Article
Kinetics
Male
Morphine/administration & dosage/blood/metabolism
Noack G
Operative
Paalzow L
Pain
Preanesthetic Medication
Preschool
Surgical Procedures