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Text
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URL Address
<a href="http://doi.org/10.1046/j.1468-2982.1992.1203155.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1468-2982.1992.1203155.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients
Publisher
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Cephalalgia
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
Subject
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Female; Humans; Male; Adult; Middle Aged; beta-Endorphin/blood; Biomarkers of Pain; Radioimmunoassay; Leukocytes; Headache/blood; Migraine Disorders/blood; Mononuclear/chemistry
Creator
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Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G
Description
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Levels of beta-endorphin in peripheral blood mononuclear cells have been studied as a new approach to investigating opioid tone in migraine and tension-type headache. Sixty-one patients with migraine without aura, 39 with migraine with aura and 23 with episodic tension-type headache were compared with 37 healthy controls. Peripheral blood samples were taken from patients not enduring headache attacks and not undergoing prophylactic treatment. A significant reduction in peripheral blood mononuclear cell beta-endorphin concentrations was observed in migraine patients with and without aura, but not in tension-type headache patients. Altered transmitter modulation to peripheral blood mononuclear cells may be the cause of this alteration, which could be part of a more diffuse opioid system derangement in migraine subjects.
1992
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1468-2982.1992.1203155.x" target="_blank" rel="noreferrer">10.1046/j.1468-2982.1992.1203155.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1992
Adult
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Bussone G
Cephalalgia
D'Amico D
Female
Headache/blood
Humans
Journal Article
Leone M
Leukocytes
Male
Middle Aged
Migraine Disorders/blood
Mononuclear/chemistry
Panerai AE
Radioimmunoassay
Sacerdote P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1046/j.1468-2982.1993.1306413.x" target="_blank" rel="noreferrer">http://doi.org/10.1046/j.1468-2982.1993.1306413.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients
Publisher
An entity responsible for making the resource available
Cephalalgia
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
Subject
The topic of the resource
Female; Humans; Male; Adult; Reference Values; beta-Endorphin/blood; Cluster Headache/blood; Monocytes/metabolism
Creator
An entity primarily responsible for making the resource
Leone M; Sacerdote P; D'Amico D; Panerai AE; Bussone G
Description
An account of the resource
Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p < 0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.
1993
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1468-2982.1993.1306413.x" target="_blank" rel="noreferrer">10.1046/j.1468-2982.1993.1306413.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1993
Adult
Backlog
beta-Endorphin/blood
Bussone G
Cephalalgia
Cluster Headache/blood
D'Amico D
Female
Humans
Journal Article
Leone M
Male
Monocytes/metabolism
Panerai AE
Reference Values
Sacerdote P