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Text
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<a href="http://doi.org/10.1016/s0024-3205(02)02415-3" target="_blank" rel="noreferrer">http://doi.org/10.1016/s0024-3205(02)02415-3</a>
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Title
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Cytokine and hormone profiles in mice subjected to handling combined with rectal temperature measurement stress and handling only stress
Publisher
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Life Sciences
Date
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2003
Subject
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Female; Animals; Mice; Stress; beta-Endorphin/blood; Biomarkers of Pain; RNA; Killer Cells; Body Temperature/physiology; Adrenocorticotropic Hormone/blood; Cytokines/blood/metabolism; Handling (Psychology); Hormones/blood/metabolism; Inbred BALB C; Messenger/biosynthesis; Natural/physiology; Psychological/metabolism; Spleen/cytology/metabolism
Creator
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Hale KD; Weigent DA; Gauthier DK; Hiramoto RN; Ghanta VK
Description
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Stress is known to either up or down regulate immunity. In this study, mice were subjected to handling combined with rectal temperature measurement (RTM) stress or handling only stress. We investigated whether there were any significant differences in the effect of handling combined with RTM and handling only on NK cell activity, serum cytokine (IL-1beta, IL-6, and TNF-alpha) and ACTH and beta-endorphin levels, and splenic cytokine (IL-1beta, IL-6, TNF-alpha, IFN-alpha, and IFN-beta) levels. Circulating cytokines and hormones and splenic cytokine mRNA levels were measured in individual mice. NK cell activity was significantly increased in both stress groups when compared to the control group. Handling combined with RTM produced significantly increased serum levels of IL-1beta, IL-6, and beta-endorphin. Serum IL-1beta, ACTH, and beta-endorphin were elevated significantly in the handling only group. Splenic TNFalpha mRNA in both of the stress groups and IL-6 mRNA in handling only group decreased significantly. Our observations are supported by existing literature demonstrating that various stressors have differential effects on immune functions and the neuroendocrine hormones and cytokines, which regulate them.
2003
Identifier
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<a href="http://doi.org/10.1016/s0024-3205(02)02415-3" target="_blank" rel="noreferrer">10.1016/s0024-3205(02)02415-3</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
2003
Adrenocorticotropic Hormone/blood
Animals
Backlog
beta-Endorphin/blood
Biomarkers of Pain
Body Temperature/physiology
Cytokines/blood/metabolism
Female
Gauthier DK
Ghanta VK
Hale KD
Handling (Psychology)
Hiramoto RN
Hormones/blood/metabolism
Inbred BALB C
Journal Article
Killer Cells
Life Sciences
Messenger/biosynthesis
Mice
Natural/physiology
Psychological/metabolism
RNA
Spleen/cytology/metabolism
Stress
Weigent DA