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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1073/pnas.0409888102" target="_blank" rel="noreferrer">http://doi.org/10.1073/pnas.0409888102</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
Publisher
An entity responsible for making the resource available
Proceedings Of The National Academy Of Sciences Of The United States Of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
Subject
The topic of the resource
Humans; Male; Animals; Rats; Biomarkers of Pain; Cells; Cultured; Analgesics/pharmacology; Sprague-Dawley; beta-Endorphin/secretion; Cannabinoid; Cannabinoids; CB2/agonists/physiology; Endothelin B/physiology; Receptor
Creator
An entity primarily responsible for making the resource
Ibrahim MM; Porreca F; Lai J; Albrecht PJ; Rice FL; Khodorova A; Davar G; Makriyannis A; Vanderah TW; Mata HP; Malan TP
Description
An account of the resource
CB(2) cannabinoid receptor-selective agonists are promising candidates for the treatment of pain. CB(2) receptor activation inhibits acute, inflammatory, and neuropathic pain responses but does not cause central nervous system (CNS) effects, consistent with the lack of CB(2) receptors in the normal CNS. To date, there has been virtually no information regarding the mechanism of CB(2) receptor-mediated inhibition of pain responses. Here, we test the hypothesis that CB(2) receptor activation stimulates release from keratinocytes of the endogenous opioid beta-endorphin, which then acts at opioid receptors on primary afferent neurons to inhibit nociception. The antinociceptive effects of the CB(2) receptor-selective agonist AM1241 were prevented in rats when naloxone or antiserum to beta-endorphin was injected in the hindpaw where the noxious thermal stimulus was applied, suggesting that beta-endorphin is necessary for CB(2) receptor-mediated antinociception. Further, AM1241 did not inhibit nociception in mu-opioid receptor-deficient mice. Hindpaw injection of beta-endorphin was sufficient to produce antinociception. AM1241 stimulated beta-endorphin release from rat skin tissue and from cultured human keratinocytes. This stimulation was prevented by AM630, a CB(2) cannabinoid receptor-selective antagonist and was not observed in skin from CB(2) cannabinoid receptor-deficient mice. These data suggest that CB(2) receptor activation stimulates release from keratinocytes of beta-endorphin, which acts at local neuronal mu-opioid receptors to inhibit nociception. Supporting this possibility, CB(2) immunolabeling was detected on beta-endorphin-containing keratinocytes in stratum granulosum throughout the epidermis of the hindpaw. This mechanism allows for the local release of beta-endorphin, where CB(2) receptors are present, leading to anatomical specificity of opioid effects.
2005
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1073/pnas.0409888102" target="_blank" rel="noreferrer">10.1073/pnas.0409888102</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2005
Albrecht PJ
Analgesics/pharmacology
Animals
Backlog
beta-Endorphin/secretion
Biomarkers of Pain
Cannabinoid
Cannabinoids
CB2/agonists/physiology
Cells
Cultured
Davar G
Endothelin B/physiology
Humans
Ibrahim MM
Journal Article
Khodorova A
Lai J
Makriyannis A
Malan TP
Male
Mata HP
Porreca F
Proceedings Of The National Academy Of Sciences Of The United States Of America
Rats
Receptor
Rice FL
Sprague-Dawley
Vanderah TW
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/1096-8628(20010422)100:2%3C122::AID-AJMG1236%3E3.0.CO" target="_blank" rel="noreferrer">http://doi.org/10.1002/1096-8628(20010422)100:2%3C122::AID-AJMG1236%3E3.0.CO</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Infantile systemic hyalinosis in siblings: clinical report, biochemical and ultrastructural findings, and review of the literature
Publisher
An entity responsible for making the resource available
American Journal Of Medical Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
Subject
The topic of the resource
Child; Humans; Male; Preschool; Non-U.S. Gov't; Research Support; Cells; Contracture/pathology; Cultured; Fibroblasts/metabolism; Hyaluronic Acid/metabolism; Hyaluronoglucosaminidase/blood; Joint Diseases/blood/congenital/radiography; Osteolysis/congenital; Proteoglycans/metabolism; Skin Diseases/blood/congenital/radiography
Creator
An entity primarily responsible for making the resource
Stucki U; Spycher MA; Eich G; Rossi A; Sacher P; Steinmann B; Superti-Furga A
Description
An account of the resource
A boy presented at age 3.5 months with joint contractures, restlessness, and pain on handling. His skin was thickened and there were livid-red macular lesions over bony prominences. Infantile systemic hyalinosis (ISH) was diagnosed, a presumably autosomal recessive, progressive, and painful disorder of as yet unknown pathogenesis. Observation over three years confirmed the diagnosis as typical changes, such as nodules on both ears, pearly papules in the perinasal folds and on the neck, fleshy nodules in the perianal region, and gingival hypertrophy, developed. Skin lesions and painful joint contractures progressed in spite of intense physiotherapy, and at age 3, the child had marked motor disability. The central nervous system (CNS) appeared to be intact and the infant showed normal mental development. Radiologic findings included marked generalized osteopenia, osteolytic erosions in the metaphyses of the long bones, and cortical thinning. Electron microscopy of two skin biopsies demonstrated deposition of floccular amorphous substance that was abundant around, and appeared to originate from, small blood vessels in the dermis, partially interfering with collagen fiber formation. Lysosomal inclusions were not seen. Serum acid hyaluronidase activity was within the normal range, and the synthesis of hyaluronic acid and proteoglycans in cultured skin fibroblasts was similar to that of control cells. A younger sister presented at age two months with painful joint contractures and discrete livid-red macules over both malleoli, and showed a similar progression of the disorder over the first year of life. The diagnosis of ISH should be considered in infants and children presenting with painful joint contractures and skin lesions. The pathogenesis of this disabling and disfiguring disorder remains unclear. Our data confirm probable autosomal recessive inheritance, and do not support lysosomal storage, hyaluronidase deficiency, or a primary collagen disorder, but indicate that the amorphous material accumulating in the skin and articular soft tissues may originate from the blood circulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/1096-8628(20010422)100:2%3C122::AID-AJMG1236%3E3.0.CO" target="_blank" rel="noreferrer">10.1002/1096-8628(20010422)100:2%3C122::AID-AJMG1236%3E3.0.CO</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2001
American Journal Of Medical Genetics
Backlog
Cells
Child
Contracture/pathology
Cultured
Eich G
Fibroblasts/metabolism
Humans
Hyaluronic Acid/metabolism
Hyaluronoglucosaminidase/blood
Joint Diseases/blood/congenital/radiography
Journal Article
Male
Non-U.S. Gov't
Osteolysis/congenital
Preschool
Proteoglycans/metabolism
Research Support
Rossi A
Sacher P
Skin Diseases/blood/congenital/radiography
Spycher MA
Steinmann B
Stucki U
Superti-Furga A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1002/1531-8257(200011)15:6%3C1199::aid-mds1020%3E3.0.co" target="_blank" rel="noreferrer">http://doi.org/10.1002/1531-8257(200011)15:6%3C1199::aid-mds1020%3E3.0.co</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Niemann-Pick disease type C: Two cases and an update.
Publisher
An entity responsible for making the resource available
Movement Disorders: Official Journal Of The Movement Disorder Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
Subject
The topic of the resource
Female; Humans; Male; Middle Aged; Disease Progression; Longitudinal Studies; adolescent; Age of Onset; Cholesterol/metabolism; Esterification; Diagnosis; Differential; Cells; Cultured; Fibroblasts/metabolism; Niemann-Pick Diseases/diagnosis/physiopathology; Skin/pathology
Creator
An entity primarily responsible for making the resource
Uc EY; Wenger DA; Jankovic J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/1531-8257(200011)15:6%3C1199::aid-mds1020%3E3.0.co" target="_blank" rel="noreferrer">10.1002/1531-8257(200011)15:6%3C1199::aid-mds1020%3E3.0.co</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
Description
An account of the resource
We describe two patients with juvenile-onset Niemann-Pick disease type C (NPC) to illustrate the variable neurologic features of this condition. One presented with hypersplenism at age 10 and was misdiagnosed with Gaucher disease. He developed complex partial seizures in his teens but remained otherwise neurologically asymptomatic until his mid 30s. At age 45, he had mild dementia and dysarthria, vertical supranuclear ophthalmoplegia, axonal sensorimotor polyneuropathy, and cerebellar ataxia. The second patient presented with rapidly progressive dystonia at age 8, and mild hepatosplenomegaly, vertical supranuclear ophthalmoplegia, severe behavioral disorder, and dementia by age 14. The diagnosis of NPC was based on deficient cholesterol esterification and excessive lysosomal filipin staining in cultured skin fibroblasts. Current notions about diagnosis and pathogenesis of NPC are reviewed.
2000
Adolescent
Age of Onset
Backlog
Cells
Cholesterol/metabolism
Cultured
Diagnosis
Differential
Disease Progression
Esterification
Female
Fibroblasts/metabolism
Humans
Jankovic J
Journal Article
Longitudinal Studies
Male
Middle Aged
Movement Disorders: Official Journal Of The Movement Disorder Society
Niemann-Pick Diseases/diagnosis/physiopathology
Skin/pathology
Uc EY
Wenger DA