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40
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Text
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URL Address
<a href="http://doi.org/10.1016/0196-9781(95)00030-n" target="_blank" rel="noreferrer">http://doi.org/10.1016/0196-9781(95)00030-n</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Age-related changes in mitogen-induced beta-endorphin release from human peripheral blood mononuclear cells
Publisher
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Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
Subject
The topic of the resource
Humans; Adult; Middle Aged; Biomarkers of Pain; Leukocytes; Aging/blood; beta-Endorphin/metabolism; Calcium-Transporting ATPases/antagonists & inhibitors; Calcium/blood; Concanavalin A/pharmacology; Homeostasis/drug effects; Ionomycin/pharmacology; Mitogens/pharmacology; Mononuclear/cytology/drug effects; Phytohemagglutinins/pharmacology; Terpenes/pharmacology; Thapsigargin
Creator
An entity primarily responsible for making the resource
Manfredi B; Clementi E; Sacerdote P; Bassetti M; Panerai AE
Description
An account of the resource
beta-Endorphin is an opioid peptide synthesized in the pituitary, hypothalamus, and immunocytes, known to affect immune responses both when added in vitro and when its synthesis is increased in vivo (e.g., during stress). We show here that, similar to its concentrations in peripheral blood mononuclear cells, the release of the opioid peptide from these cells after stimulation with polyclonal mitogens such as PHA or Con-A is also age dependent. Moreover, the effect of both mitogens on Ca2+ homeostasis changes with age. Finally, the ionophore ionomycin and the Ca2+ ATPase blocker thapsigargin induce the same age related effect on beta-endorphin release. For these reasons, we suggest that calcium homeostasis might be important for the differences observed in the release of the opioid from cells obtained from younger ( or = 45 years) volunteers.
1995
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0196-9781(95)00030-n" target="_blank" rel="noreferrer">10.1016/0196-9781(95)00030-n</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
1995
Adult
Aging/blood
Backlog
Bassetti M
beta-Endorphin/metabolism
Biomarkers of Pain
Calcium-Transporting ATPases/antagonists & inhibitors
Calcium/blood
Clementi E
Concanavalin A/pharmacology
Homeostasis/drug effects
Humans
Ionomycin/pharmacology
Journal Article
Leukocytes
Manfredi B
Middle Aged
Mitogens/pharmacology
Mononuclear/cytology/drug effects
Panerai AE
Peptides
Phytohemagglutinins/pharmacology
Sacerdote P
Terpenes/pharmacology
Thapsigargin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Citation List Month
Backlog
URL Address
<a href="http://doi.org/10.1111/j.1749-6632.2002.tb04247.x" target="_blank" rel="noreferrer">http://doi.org/10.1111/j.1749-6632.2002.tb04247.x</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Opioid peptides endomorphin-1 and endomorphin-2 in the immune system in humans and in a rodent model of inflammation
Publisher
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Annals Of The New York Academy Of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
Subject
The topic of the resource
Humans; Male; Animals; Rats; Non-U.S. Gov't; Research Support; Arthritis; Radioimmunoassay; Concanavalin A/pharmacology; Wistar; Spleen/chemistry; Thymus Gland/chemistry; Morphine/pharmacology; Apoptosis/drug effects; Experimental/immunology/metabolism; Lipopolysaccharides/pharmacology; Lymphocyte Activation/drug effects; Lymphocyte Subsets/chemistry/drug effects; Oligopeptides/analysis/pharmacology; Synovial Fluid/chemistry
Creator
An entity primarily responsible for making the resource
Jessop DS; Richards LJ; Harbuz MS
Description
An account of the resource
Endomorphin (EM)-1 and EM-2 are tetrapeptides with high affinity and selectivity for the micro-opioid receptor. We have utilized specific radioimmunoassays to characterize EM-1 and EM-2 in immune tissues from normal human subjects and from rats with adjuvant arthritis (AA). PBLs from three normal human subjects contained 248, 13, and 303 pg EM-1 per 100 million cells, whereas EM-2 was measured in two subjects at 69 and 588 pg per 100 million cells. In AA rats, EM-1 (but not EM-2) contents in the spleen and thymus were elevated compared with levels in tissues from non-AA controls. EM-1 was detectable in five of eight samples of synovial tissue from inflamed hind paws, whereas EM-2 was detectable in two of eight synovial extracts. Neither EM-1 nor EM-2 were detectable in synovial tissue from non-AA rats. To our knowledge, this is the first report of endomorphins in normal human immune cells. Increased endomorphin expression or uptake in peripheral tissues in a rodent model of chronic inflammation provides potential for endomorphins to selectively modulate chronic inflammation in mammals.
2002
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1749-6632.2002.tb04247.x" target="_blank" rel="noreferrer">10.1111/j.1749-6632.2002.tb04247.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
The nature or genre of the resource
Journal Article
2002
Animals
Annals Of The New York Academy Of Sciences
Apoptosis/drug effects
Arthritis
Backlog
Concanavalin A/pharmacology
Experimental/immunology/metabolism
Harbuz MS
Humans
Jessop DS
Journal Article
Lipopolysaccharides/pharmacology
Lymphocyte Activation/drug effects
Lymphocyte Subsets/chemistry/drug effects
Male
Morphine/pharmacology
Non-U.S. Gov't
Oligopeptides/analysis/pharmacology
Radioimmunoassay
Rats
Research Support
Richards LJ
Spleen/chemistry
Synovial Fluid/chemistry
Thymus Gland/chemistry
Wistar