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Text
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URL Address
<a href="http://doi.org/10.1097/00132586-198606000-00011" target="_blank" rel="noreferrer">http://doi.org/10.1097/00132586-198606000-00011</a>
Dublin Core
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Title
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Endogenous opioid activity in clinical hemorrhagic shock
Publisher
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Surgery, Gynecology & Obstetrics
Date
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1985
Subject
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Female; Humans; Male; Adult; Aged; Middle Aged; Blood Pressure; adolescent; Biomarkers of Pain; Radioimmunoassay; Wounds; Hydrocortisone/blood; Accidents; Endorphins/blood/metabolism; Hemorrhagic/blood/etiology/physiopathology; Nonpenetrating/blood/etiology/physiopathology; Shock; Traffic; Trauma Centers
Creator
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Shatney CH; Cohen RM; Cohen MR; Imagawa DK
Description
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Plasma beta-endorphin, cortisol and total opioid-like activities were measured upon arrival at the hospital in ten patients with extensive trauma and in a state of shock and 11 patients with minor injury. Patients in a state of shock had significantly (p less than 0.01) higher mean plasma beta-endorphin immunoreactivity than patients with minor trauma (128.8 +/- 24.8 picomolars versus 31.7 +/- 5.6 picomolars). There were no significant intergroup differences in the mean plasma cortisol concentration (27.7 +/- 4.7 micrograms per deciliter versus 20.6 +/- 2.7 micrograms per deciliter) or opioid ligand activity (2.28 +/- 0.62 nanomolars versus 3.17 +/- 0.99 nanomolars). These data are consistent with the hypothesis that certain endogenous opioids may be physiopathologic factors in hemorrhagic shock but provide no proof of a cause and effect relationship.
1985
Identifier
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<a href="http://doi.org/10.1097/00132586-198606000-00011" target="_blank" rel="noreferrer">10.1097/00132586-198606000-00011</a>
Rights
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
Type
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Journal Article
1985
Accidents
Adolescent
Adult
Aged
Backlog
Biomarkers of Pain
Blood Pressure
Cohen MR
Cohen RM
Endorphins/blood/metabolism
Female
Hemorrhagic/blood/etiology/physiopathology
Humans
Hydrocortisone/blood
Imagawa DK
Journal Article
Male
Middle Aged
Nonpenetrating/blood/etiology/physiopathology
Radioimmunoassay
Shatney CH
Shock
Surgery, Gynecology & Obstetrics
Traffic
Trauma Centers
Wounds