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Dublin Core
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Title
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Treatment of Symptoms in Children with Q3 Conditions Scoping Review Results
Text
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<a href="http://doi.org/10.1016/s0006-3223(01)01231-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-3223(01)01231-8</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Psychiatric disorders and behavioral problems in children with velocardiofacial syndrome: usefulness as phenotypic indicators of schizophrenia risk
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Biological Psychiatry
Date
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2002
Subject
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Male; Comorbidity; Child; Humans; Adult; Adolescent; Female; Risk Factors; Phenotype; Child Behavior Disorders/genetics/psychology; Chromosome Deletion; Chromosomes Human Pair 22/genetics; Cognition Disorders/genetics/psychology; Developmental Disabilities/genetics/psychology; Mental Disorders/genetics/psychology; Schizophrenia/genetics; behavioral problems; 22q11.2 deletion syndrome; trajectory; characteristics
Creator
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Feinstein C; Eliez S; Blasey C; Reiss A L
Description
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BACKGROUND: Velocardiofacial syndrome (VCFS), a genetic deletion condition with numerous cognitive sequelae, is associated with a high rate of psychiatric disorders in childhood. More recently, VCFS has been identified as a high-risk factor for developing adult onset schizophrenia. However, it has never been demonstrated that the childhood psychiatric disorders found in children with VCFS differ from those found in children with a similar degree of cognitive impairment. Identification of a specific behavioral (psychiatric) phenotype in childhood VCFS offers the potential for elucidating the symptomatic precursors of adult onset schizophrenia. METHODS: Twenty-eight children with VCFS and 29 age- and cognitively matched control subjects received a standardized assessment of childhood psychiatric disorders and behaviors measured by the Child Behavior Checklist (CBCL). Findings from the two groups were compared. RESULTS: The rates and types of psychiatric disorder and behavior problems in VCFS and cognitively matched control subjects were very high, but showed no significant differences. CONCLUSIONS: Psychopathology in children with VCFS may not differ from that found in cognitively matched control subjects. Another explanation is that subtle phenotypic differences in behavior found in VCFS can not be observed using standard symptom inventories. The high rate of psychopathology in children with VCFS is not a useful phenotypic indicator of high risk for adult onset schizophrenia.
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<a href="http://doi.org/10.1016/s0006-3223(01)01231-8" target="_blank" rel="noreferrer noopener">10.1016/s0006-3223(01)01231-8</a>
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Article information provided for research and reference use only. PedPalASCNET does not hold any rights over the resource listed here. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
22q11.2 Deletion Syndrome
Adolescent
Adult
behavioral problems
Biological Psychiatry
Blasey C
characteristics
Child
Child Behavior Disorders/genetics/psychology
Chromosome Deletion
Chromosomes Human Pair 22/genetics
Cognition Disorders/genetics/psychology
Comorbidity
Developmental Disabilities/genetics/psychology
Eliez S
Feinstein C
Female
Humans
Male
Mental Disorders/genetics/psychology
Phenotype
Reiss A L
Risk Factors
Schizophrenia/genetics
Trajectory